Clozapine impurity 8
Clozapine impurity 8 is an impurity of Clozapine (HY-14539).
For research use only. We do not sell to patients.
- Purity: 99.29%
- CAS No.: 5814-41-5
- Formula: C13H10N2O
- Molecular Weight:210.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
37.1 μM
Compound: 1; dibenzodiazepinone
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 26735909] |
| MCF7 | IC50 |
>50 μM
Compound: 1; dibenzodiazepinone
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 26735909] |
| MDA-MB-231 | IC50 |
>50 μM
Compound: 1; dibenzodiazepinone
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Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 26735909] |
| PC-3 | IC50 |
41.89 μM
Compound: 1; dibenzodiazepinone
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Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 26735909] |
| U-87MG ATCC | IC50 |
8.97 μM
Compound: 1; dibenzodiazepinone
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Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 26735909] |
Chemical Information
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CAS No. 5814-41-5
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Appearance Solid
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Molecular Weight 210.24
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Formula C13H10N2O
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SMILES
O=C1C2=CC=CC=C2NC3=CC=CC=C3N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 51 mg/mL (242.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (249 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7565 mL | 23.7823 mL | 47.5647 mL | 118.9117 mL |
| 5 mM | 0.9513 mL | 4.7565 mL | 9.5129 mL | 23.7823 mL | |
| 10 mM | 0.4756 mL | 2.3782 mL | 4.7565 mL | 11.8912 mL | |
| 15 mM | 0.3171 mL | 1.5855 mL | 3.1710 mL | 7.9274 mL | |
| 20 mM | 0.2378 mL | 1.1891 mL | 2.3782 mL | 5.9456 mL | |
| 25 mM | 0.1903 mL | 0.9513 mL | 1.9026 mL | 4.7565 mL | |
| 30 mM | 0.1585 mL | 0.7927 mL | 1.5855 mL | 3.9637 mL | |
| 40 mM | 0.1189 mL | 0.5946 mL | 1.1891 mL | 2.9728 mL | |
| 50 mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 2.3782 mL | |
| 60 mM | 0.0793 mL | 0.3964 mL | 0.7927 mL | 1.9819 mL | |
| 80 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4864 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1891 mL |
Clozapine impurity 8 Related Classifications
HY-42109 Related Classifications
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