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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Cystathionine γ-lyase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Cystathionine γ-lyase" in MCE Product Catalog:
Target:
Research Areas:
Cystathionine γ-lyase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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1 Cited Publications
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Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM . Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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1 Cited Publications
Cat. No.: HY-P70025
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTH; Cysteine Desulfhydrase; Cystathionine Gamma-lyase; Gamma-Cystathionase; CSE; CGL; Cystathionase (Cystathionine Gamma-lyase); Homoserine Dehydratase; Cysteine-Protein Sulfhydrase; Homoserine Deaminase; Homocysteine Desulfhydrase
Species:
Human
Source:
E. coli
Target:
Cat. No.: HY-N3540
CAS No.: 354553-35-8
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Cat. No.: HY-169212
CAS No.: 445238-07-3
I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC50 of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways .
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Cat. No.: HY-W422507
CAS No.: 30845-11-5
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S-(3-Carboxypropyl)-L-cysteine is a Cystathionine γ-lyase (HY-E70344) (CSE) inhibitor with an IC50 of 71 μM, Ki values of 50 μM and 180 μM, and a Kd of 26 μM against human CSE. It exhibits selectivity for CSE compared to other hydrogen sulfide biosynthesizers. S-(3-Carboxypropyl)-L-cysteine is membrane permeable and inhibits transsulfurization flux in cultured cells .
Cat. No.: HY-181717
CAS No.: 3098518-95-4
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Research Areas:
TKL002 is a blood-brain barrier-permeable inhibitor of the CTH/H2S/NF-κB/EMT signaling axis. TKL002 induces G2/M phase cell cycle arrest and apoptosis in glioblastoma cells. TKL002 inhibits the migration and invasion of glioblastoma cells by upregulating E-cadherin and downregulating N-cadherin and vimentin. TKL002 is applicable to relevant research on glioblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
