445238-07-3
445238-07-3
Chemical Structure
I194496
- CAS 番号: 445238-07-3
- Formula:C28H23F2N5O5S
- Molecular Weight:579.57
InChIKey: ZTPFHENMBOHFMG-UHFFFAOYSA-N
SMILES: O=C(C1=C(N=C(C2=CC=C(OC)C=C2)C=C3C(F)F)N3N=C1)NC4=CC=C(S(=O)(NC5=C(OC)C=CC=C5)=O)C=C4
Biological Activity: I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC50 of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways[1].
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I194496 | 98.52% | I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC50 of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.56
HY-162312LLK203 -
Similarity Score 0.53
HY-12068RPI3K-IN-1 (Standard) -
Similarity Score 0.53
HY-115924CDK1-IN-1 -
Similarity Score 0.53
HY-W140974SN-001 -
Similarity Score 0.53
HY-128333PI3K/mTOR Inhibitor-4 -
Similarity Score 0.52
HY-123722NusB-NusE interaction IN-1 -
Similarity Score 0.52
HY-153076Flaviviruses-IN-3 -
Similarity Score 0.52
HY-146979hA2A/hCA XII modulator 1 -
Similarity Score 0.50
HY-110125ML-193 -
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