NusB-NusE interaction IN-1 

NusB-NusE interaction IN-1 (compound 1) is a NusB-NusE protein-protein interaction inhibitor and growth inhibitor with a Bacillus subtilis IC₅₀ of 6.1 μM.NusB-NusE interaction IN-1 inhibits growth of Gram-positive Bacillus subtilis.NusB-NusE interaction IN-1 inhibits growth of Gram-negative Escherichia coli^[1].

NusB-NusE interaction IN-1 (compound 1) (25 μM; 15 min at 37 °C, 1 h at room temperature) potently inhibits the protein-protein interaction between Bacillus subtilis NusB and NusE with an IC₅₀ of 6.1 μM, achieving 88% inhibition at a 25 μM concentration^[1].
NusB-NusE interaction IN-1 (compound 1) (200 μM; 16 h at 37 °C) moderately inhibits the growth of Bacillus subtilis (9% inhibition) and Escherichia coli DH5α (21% inhibition) at a 200 μM concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

564.61

C₂₈H₂₈N₄O₇S

125966-81-6

O=C(NC1=CC=C(C=C1)S(=O)(=O)NC=2N=C(C=C(N2)C=3C=CC(OC)=CC3OC)C=4C=CC(OC)=C(OC)C4)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cossar PJ, et al. Identification and validation of small molecule modulators of the NusB-NusE interaction. Bioorg Med Chem Lett. 2017;27(2):162-167.  [Content Brief]