2 Results for "

EGFR/COX-2-IN-2

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "EGFR/COX-2-IN-2" in MCE Product Catalog:

Cat. No.: HY-178440
Target:  

EGFR COX Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

EGFR/COX-2-IN-2 (Compound 10a) is a dual inhibitor targeting epidermal growth factor receptor (EGFR) (IC50= 6.0 μM) and cyclooxygenase-2 (COX-2) (IC50=50 μM). EGFR/COX-2-IN-2 induces S-phase cell cycle arrest and apoptosis. EGFR/COX-2-IN-2 is promising for research of cancers and inflammation-related diseases .
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Cat. No.: HY-165394
CAS No.: 129724-42-1
Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research .
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