Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
ER degrader-10
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "ER degrader-10" in MCE Product Catalog:
Cat. No.: HY-170377
CAS No.: 3035311-43-1
Research Areas:
ER degrader 10 (Compound 51) is a selective, orally active degrader and antagonist for estrogen receptor (ER) with a DC50 of 0.43 nM and an IC50 of 0.56 nM. ER degrader 10 inhibits the proliferation of ER-positive cells with IC50s of 0-15 nM. ER degrader 10 exhibits a weak inhibitory activity against hERG channel with an IC50 >40 μM. ER degrader 10 is blood-brain barrier penetrable with a brain/plasma ratio (Kp) of 3.05. ER degrader 10 exhibits antitumor efficacy in mice model .
Cat. No.: HY-168099
Target:
Research Areas:
ERα degrader 10 is a selective and orally active estrogen receptor α (ERα) degrader. ERα degrader 10 exhibits potent ERα binding affinity (IC50 of 24.0 nM) and degradation ability (EC50 of 5.3 nM). ERα degrader 10 degrades ERα through the proteasome-mediated pathway. ERα degrader 10 can be used for the study of breast cancer .
Cat. No.: HY-145073
CAS No.: 2504911-58-2
Target:
Research Areas:
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.
Cat. No.: HY-170336
CAS No.: 2421260-43-5
Target:
Research Areas:
PROTAC ERα Degrader-10 is an orally active estrogen receptor α (ERα) PROTAC degrader, with DC50 values of 0.37, 1.1, and 0.47 nM in MCF7, T47D, and CAMA-1 cells, respectively. PROTAC ERα Degrader-10 exhibits significant anti-tumor activity both in vitro and in vivo, and can be used for breast cancer research .
Cat. No.: HY-170339
CAS No.: 2421262-07-7
Research Areas:
ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336) .
Cat. No.: HY-W998234
CAS No.: 3026842-89-4
Research Areas:
(3S) Lenalidomide-5-Pip-Boc is an E3 ligase ligand-linker conjugate that is applicable to research related to PROTAC synthesis. (3S) Lenalidomide-5-Pip-Boc serves as the E3 ligase ligand-linker conjugate for PROTAC ERα Degrader-10 (HY-170336) and PROTAC ER Degrader-14 (HY-170340) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
