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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Endoplasmic Reticulum Aminopeptidase 1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Endoplasmic Reticulum Aminopeptidase 1" in MCE Product Catalog:
5
5 Cited Publications
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ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .
Cat. No.: HY-169913
CAS No.: 2766036-51-3
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ERAP1 modulator-1 (Compound 1) is the modulator for endoplasmic reticulum aminopeptidase 1 (ERAP1) with IC50 < 250 nM .
Cat. No.: HY-168181
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ERAP1-IN-2 (compound 3f) is an inhibitor of ERAP1 (endoplasmic reticulum aminopeptidase 1). ERAP1-IN-2 has an IC50 value of 1.72 μM against hERAP1 .
Cat. No.: HY-169936
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ERAP1-IN-3 (compound 13) is a potent endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor, with a pIC50 of 8.6. ERAP1-IN-3 has potential for the research of cancer immunotherapy and autoimmune disease .
Cat. No.: HY-P82414
Synonyms: ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic Reticulum Aminopeptidase 1; ARTS-1; Adipocyte-derived leucine Aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific Aminopeptidase; PILS-AP; Type 1 tumor necrosis facto
Cat. No.: HY-P82414A
Synonyms: ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic Reticulum Aminopeptidase 1; ARTS-1; Adipocyte-derived leucine Aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific Aminopeptidase; PILS-AP; Type 1 tumor necrosis facto
Cat. No.: HY-179625
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GSK235 is an orally active, selective and allosteric endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor with pIC50 values of 8.45 and 7.59 for human and mouse ERAP1, respectively. GSK235 exhibits over 1000-fold selectivity for the two most homologous enzymes, ERAP2 and IRAP. GSK235 can regulate the immunopeptidome of cancer cells and enhance cancer cell antigenicity. GSK235 can be used for the study of colorectal cancer and arthritis .
Cat. No.: HY-183267
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ERAP1-IN-4 is an orally acvtive endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor with a pIC50 of 7.9 and an LLE of 5.3. ERAP1-IN-4 inhibits hydrolysis of peptide substrates by ERAP1, with high activity against Allotype1 and Allotype2. ERAP1-IN-4 reduced efficacy against other allotypes, and modulates ERAP1-mediated peptide processing to inhibit antigenic epitope presentation. ERAP1-IN-4 can be used for the research of cancer[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
