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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
Enterobacter cloacae P99 β-lactamase
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "Enterobacter cloacae P99 β-lactamase" in MCE Product Catalog:
Cat. No.: HY-U00380
CAS No.: 102507-71-1
Target:
Research Areas:
Tigemonam is an orally active monobactam antibiotic with a Ki of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .
Cat. No.: HY-14879D
CAS No.: 396731-20-7
Synonyms: rel-NXL-104; rel-AVE1330A
Target:
Research Areas:
rel-Avibactam sodium (rel-NXL-104) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections .
Cat. No.: HY-187660
CAS No.: 396731-14-9
Synonyms: rel-NXL-104 free acid; rel-AVE1330A free acid
Target:
Research Areas:
rel-Avibactam (rel-NXL-104 free acid) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
