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Geissoschizine methyl ether

" in MedChemExpress (MCE) Product Catalog:
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Geissoschizine methyl ether
Geissoschizine methyl ether
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Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
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