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Results for "

HSP27

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (16) Hsp-targeting Chimeras (1) Androgen Receptor (1) Apoptosis (8) Autophagy (2) Bacterial (1) Caspase (1) Claudin (2) DNA/RNA Synthesis (1) Early 2 Factor (E2F) (1) ERK (2) iGluR (4) Interleukin Related (4) JNK (2) LPL Receptor (1) MAPKAPK2 (MK2) (3) Mitophagy (2) NF-κB (1) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (2) p38 MAPK (9) PGC-1α (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) SHP1 (2) SHP2 (2) Sirtuin (1) Small Interfering RNA (siRNA) (4) TNF Receptor (7) VEGFR (4)
By Research Areas:	Cancer (21) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) Antisense Oligonucleotides (2) siRNAs (4)

Inhibitors & Agonists

Peptides

Natural
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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Hsp-targeting Chimeras HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10256

Adezmapimod Maximum Cited Publications 601 Publications Verification SB 203580; RWJ 64809	Organoid p38 MAPK Autophagy Mitophagy HSP	Inflammation/Immunology Cancer
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator .

HY-124653

HSP27 inhibitor J2 5+ Cited Publications J2	HSP	Cancer
HSP27 inhibitor J2 (J2) is a *HSP27* inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and *HSP27* inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-18669

ML346 5+ Cited Publications	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

HY-18756

NSC-87877 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-145722

Apatorsen sodium 1 Publications Verification OGX-427 sodium	HSP	Cancer
Apatorsen (OGX-427) sodium is a 2'-methoxyethyl-modified antisense oligonucleotide and also a *Hsp27* inhibitor. Apatorsen sodium reduces *Hsp27* mRNA and protein levels, impairs stress-induced cytoprotective functions, induces cell apoptosis, inhibits tumor growth and prevents metastasis. Apatorsen sodium is applicable to research related to non-small cell lung cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer and bladder cancer .

HY-138280

DTHIB 5+ Cited Publications	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research .

HY-B0369A

Orphenadrine citrate	iGluR	Neurological Disease Cancer
Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-10406

Talmapimod 3 Publications Verification SCIO-469	p38 MAPK TNF Receptor Interleukin Related VEGFR Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC₅₀ of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) .

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀ of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R .

HY-145722A

Apatorsen 1 Publications Verification OGX-427	HSP	Cancer
Apatorsen is a 2'-methoxyethyl-modified antisense oligonucleotide and also a *Hsp27* inhibitor. Apatorsen reduces *Hsp27* mRNA and protein levels, impairs stress-induced cytoprotective functions, induces cell apoptosis, inhibits tumor growth and prevents metastasis. Apatorsen is applicable to research related to non-small cell lung cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer and bladder cancer .

HY-18756A

NSC-87877 disodium 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-P10072A

MK2-IN-5 acetate HSP25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-N11262

Sudachitin	Phosphodiesterase (PDE) Sirtuin PGC-1α p38 MAPK HSP TNF Receptor NO Synthase Apoptosis	Metabolic Disease Inflammation/Immunology
Sudachitin is an orally active compound that potently inhibits mouse PDE1C and human PDE4B, with IC₅₀ values of 5.0 μM and 15.0 μM, respectively. Sudachitin upregulates Sirt1 and PGC‑1α expression in skeletal muscle to regulate energy metabolism and promote mitochondrial biogenesis. Sudachitin improves lipid metabolism, glucose tolerance, insulin sensitivity, energy expenditure, and fatty acid β‑oxidation. Sudachitin activates p38MAPK signaling, induces *HSP27* phosphorylation and caspase‑dependent apoptosis, and blocks EGF‑driven keratinocyte migration and proliferation. Sudachitin suppresses LPS‑induced TNF‑α, NO, and iNOS expression in macrophages and shows potent anti‑inflammatory activity. Sudachitin can be used for the research of metabolic syndrome, type 2 diabetes, and psoriasis. .

HY-RS06438

HSPB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSPB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSPB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSPB1 Human Pre-designed siRNA Set A HSPB1 Human Pre-designed siRNA Set A

HY-10256R

Adezmapimod (Standard) SB 203580 (Standard); RWJ 64809 (Standard)	Organoid Reference Standards p38 MAPK Autophagy Mitophagy HSP	Inflammation/Immunology Cancer
Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator .

HY-117987

CPS-11 N-(Hydroxymethyl)thalidomide	Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species (ROS)	Cancer
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines .

HY-B1126

Orphenadrine hydrochloride	iGluR	Neurological Disease Cancer
Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-P10072

MK2-IN-5 HSP25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Reference Standards TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-182809

Androgen receptor degrader-6	Hsp-targeting Chimeras Androgen Receptor HSP	Neurological Disease Cancer
Androgen receptor degrader-6 is a blood-brain barrier-permeable AR degrader. Androgen receptor degrader-6 inhibits the chaperone activity of *HSP27* and disrupts the *HSP27*-AR complex. Androgen receptor degrader-6 promotes the degradation of wild-type and mutant AR, reduces AR protein levels, and inhibits the growth of glioblastoma cells. Androgen receptor degrader-6 can be used in glioblastoma research .

HY-123922

NOSO-502	Bacterial	Infection
NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties .

HY-123303

NSC-134754 NZ-28	HSP	Cancer
NSC-134754 is a dehydroemetine derivative and heat shock protein induction inhibitor. NSC-134754 acts at the post-transcriptional level, targets *Hsp72* and *Hsp27, and does not alter general protein synthesis, HSF-1* transcriptional activity, or Hsp mRNA levels. NSC-134754 shows no significant toxicity in preclinical models and sensitizes cancer cells to proteasome and *Hsp90* inhibitors. NSC-134754 can be used for the research of multiple myeloma, prostate carcinoma, colon carcinoma .

HY-RS24382

Hspb1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hspb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hspb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hspb1 Rat Pre-designed siRNA Set A Hspb1 Rat Pre-designed siRNA Set A

HY-182596

INHIB1X	MAPKAPK2 (MK2)	Inflammation/Immunology Cancer
INHIB1X is a tetracyclic MAPKAP-K2 (MK2) inhibitor with an IC₅₀ of 0.02 μM. INHIB1X inhibits LPS-induced TNFα release in human peripheral blood mononuclear cells (hPBMCs). INHIB1X suppresses the phosphorylation of *hsp27* in Anisomycin-stimulated THP-1 cells. INHIB1X can be used for the research of inflammatory and tumor diseases .

HY-RS06439

HSPB2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSPB2 Human Pre-designed siRNA Set A contains three designed siRNAs for HSPB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSPB2 Human Pre-designed siRNA Set A HSPB2 Human Pre-designed siRNA Set A

HY-RS20956

Hspb2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hspb2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hspb2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hspb2 Mouse Pre-designed siRNA Set A Hspb2 Mouse Pre-designed siRNA Set A

HY-10406A

Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK TNF Receptor Interleukin Related VEGFR Apoptosis	Cancer
Talmapimod (SCIO-469) hydrochloride is an orally active and selective inhibitor of p38α MAPK with an IC₅₀ of 9 nM. Talmapimod hydrochloride inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod hydrochloride inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod hydrochloride can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) .

HY-B1126R

Orphenadrine hydrochloride (Standard)	Reference Standards iGluR	Neurological Disease Cancer
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-B0369AR

Orphenadrine citrate (Standard)	Reference Standards iGluR	Neurological Disease
Orphenadrine (citrate) (Standard) is the analytical standard of Orphenadrine (citrate). This product is intended for research and analytical applications. Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-164184

Ly101-4B	Apoptosis Caspase HSP Early 2 Factor (E2F) DNA/RNA Synthesis	Cancer
Ly101-4B is an apoptosis inducer and multi-target inhibitor with antiproliferative, antitumor and cycytotoxic effects. Ly101-4B reduces HSF1 expression, inhibits microRNA-214 synthesis, downregulates *HSP27, HSP70* and HSP90 expression, while suppressing E2F-dependent transcriptional activity and downregulating its target genes. Ly101-4B induces caspase 3/7-mediated apoptosis by reducing DNA synthesis, inhibiting the cell cycle and G1/S phase transition, without affecting RNA synthesis or inducing necrosis. Ly101-4B is selective for pancreatic ductal adenocarcinoma cells with different genotypes and varying degrees of E2F dependence. Ly101-4B can be used in research related to epithelial ovarian cancer and pancreatic ductal adenocarcinoma .

HY-10406B

rel-Talmapimod hydrochloride rel-SCIO-469 hydrochloride	p38 MAPK TNF Receptor Interleukin Related VEGFR Apoptosis	Cancer
rel-Talmapimod (rel-SCIO-469) hydrochloride is an orally active and selective inhibitor of p38α MAPK with an IC₅₀ of 9 nM. rel-Talmapimod hydrochloride inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. rel-Talmapimod hydrochloride inhibits the growth of multiple myeloma cells and induces apoptosis. rel-Talmapimod hydrochloride can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) .

HY-10406R

Talmapimod (Standard) SCIO-469 (Standard)	Reference Standards p38 MAPK TNF Receptor Interleukin Related VEGFR Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Talmapimod (Standard) is the analytical standard of Talmapimod (HY-10406). This product is intended for research and analytical applications. Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC₅₀ of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) .

HY-181478

Hsp90-IN-45	HSP	Cancer
Hsp90-IN-45 is a *Hsp90* inhibitor. Hsp90-IN-45 competitively binds to the ATP-binding site of purified Hsp90α with a K_d of 70 nM, blocks ATP hydrolysis, and disrupts Hsp90 client signaling. Hsp90-IN-45 inhibits ATPase activity of purified Hsp90α. Hsp90-IN-45 will be radiolabeled with ⁷⁶/ ⁷⁷Br for use as a radiotheragnostic agent for PET imaging and Meitner-Auger electron therapy. Hsp90-IN-45 can be used for the research of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P10072A

MK2-IN-5 acetate HSP25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-P10072

MK2-IN-5 HSP25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	Zea mays L. Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharides Source Classification	TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and *HSP27* inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N11262

Sudachitin	Structural Classification Flavonoids Flavones Rutaceae Citrus sudachi Hort. ex Shirai. Plants Source Classification	Phosphodiesterase (PDE) Sirtuin PGC-1α p38 MAPK HSP TNF Receptor NO Synthase Apoptosis
Sudachitin is an orally active compound that potently inhibits mouse PDE1C and human PDE4B, with IC₅₀ values of 5.0 μM and 15.0 μM, respectively. Sudachitin upregulates Sirt1 and PGC‑1α expression in skeletal muscle to regulate energy metabolism and promote mitochondrial biogenesis. Sudachitin improves lipid metabolism, glucose tolerance, insulin sensitivity, energy expenditure, and fatty acid β‑oxidation. Sudachitin activates p38MAPK signaling, induces *HSP27* phosphorylation and caspase‑dependent apoptosis, and blocks EGF‑driven keratinocyte migration and proliferation. Sudachitin suppresses LPS‑induced TNF‑α, NO, and iNOS expression in macrophages and shows potent anti‑inflammatory activity. Sudachitin can be used for the research of metabolic syndrome, type 2 diabetes, and psoriasis. .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Structural Classification Zea mays L. Polysaccharides Gramineae Plants Saccharides Source Classification	Reference Standards TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74878

	HSP27/HSPB1 Protein, Human (His) Heat shock protein beta-1; HSPB1; HSP 27; SRP27; HSPB1; HSP28	Human	E. coli
	The HSP27/HSPB1 protein is a small heat shock protein that acts as a molecular chaperone, possibly maintaining denatured proteins in a foldable state. In addition to its chaperone role, it crucially enhances stress resistance and contributes to actin organization. HSP27/HSPB1 Protein, Human (His) is the recombinant human-derived HSP27/HSPB1 protein, expressed by E. coli , with C-His labeled tag.

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Host:	Mouse (4) Rabbit (6)
Reactivity:	Human (10) Rat (1) Mouse (3) Monkey (2)
Application:	IHC-P (5) ICC/IF (8) IP (2) IHC-F (2) WB (10) ChIP (1) ELISA (1)
Isotype:	IgG (6) IgG1 (3)
Conjugation:	Non-conjugated (10)
Clonality:	Polyclonal (2) Monoclonal (6) Recombinant (2)
Modification:	Phosphorylated (3) Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86095

	Hsp27 Antibody (YA5787) HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Hsp27 Antibody (YA5787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp27.

HY-P80709

	Hsp27 Antibody (YA732) HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
	Hsp27 Antibody (YA732) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp27.

HY-P80709A

	Hsp27 Antibody (YA732)(PBS only) HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
	Hsp27 Antibody (YA732) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp27.

HY-P81306

	SAFB1 Antibody (YA1042) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, ICC/IF, ChIP	Human
	SAFB1 Antibody (YA1042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAFB1.

HY-P81306A

	SAFB1 Antibody (YA1043) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
	SAFB1 Antibody (YA1043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAFB1.

HY-P85538

	SAFB1 Antibody (YA5230) DKFZp779C1727; glutathione S transferase fusion protein; HAP; HET; HSP27 ERE TATA binding protein; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF B; SAF-B1; SAFB 1; SAFB; SAFB1; SAFB1_HUMAN; scaffold attachment factor B1.	WB, ICC/IF	Human
	SAFB1 Antibody (YA5230) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SAFB1.

HY-P81306AA

	SAFB1 Antibody (YA1043)(PBS only) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
	SAFB1 Antibody (YA1043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAFB1.

HY-P80823

	*Phospho-Hsp27* (Ser78) Antibody** HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF	Human
	Phospho-Hsp27 (Ser78) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Hsp27 (Ser78).

HY-P80824

	*Phospho-Hsp27* (Ser82) Antibody** HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P	Human
	Phospho-Hsp27 (Ser82) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Hsp27 (Ser82).

HY-P80465

	*Phospho-Hsp27* (Ser82) Antibody (YA187)**	WB, IP	Human
	Phospho-Hsp27 (Ser82) Antibody (YA187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Hsp27 (Ser82).