HVEM

By Targets:	Akt (1) Apoptosis (3) CD28 (1) IFNAR (1) Interleukin Related (1) MHC (1) mTOR (1) Small Interfering RNA (siRNA) (2) TNF Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99961

Tifcemalimab JS004; Icatolimab	CD28	Cancer
Tifcemalimab (JS004; Icatolimab) is a humanized IgG4 monoclonal antibody against BTLA (B and T lymphocyte attenuator). By binding to BTLA, tifcemalimab blocks the interaction of *HVEM-BTLA*, thereby inhibiting the BTLA-mediated inhibitory signaling pathway. Tifcemalimab can be used in research related to squamous cell non-small cell lung cancer .

HY-P10851

HVEM(14-39)	Apoptosis	Inflammation/Immunology Cancer
HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with BTLA with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of BTLA and *HVEM* in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer .

HY-159885

MG-B-28	Apoptosis	Cancer
MG-B-28 is an inhibitor of *BTLA-HVEM* with an IC₅₀ value of 906 nM. MG-B-28 promotes T-cell activation in a dose-dependent manner by blocking the *BTLA-HVEM* interaction .

HY-RS14806

TNFRSF14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF14 Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF14 Human Pre-designed siRNA Set A TNFRSF14 Human Pre-designed siRNA Set A

HY-P992201

Anti-CD160 Antibody (MAT 302) CL1-R2	MHC Apoptosis IFNAR TNF Receptor Interleukin Related Akt mTOR	Cardiovascular Disease Neurological Disease Cancer
Anti-CD160 Antibody (MAT 302) (CL1-R2) is a human monoclonal antibody targeting CD160. Anti-CD160 Antibody (MAT 302) blocks the *CD160-HVEM* protein interaction, inhibits FGF2-mediated renal tubular vascular growth, and induces endothelial cell apoptosis. Anti-CD160 Antibody (MAT 302) targets CD160 on neovascularization to exert anti-angiogenic and vascular normalization effects, trigger the production of IFN-γ, TNF and IL-6 by NK cells, and enhance glucose metabolism of NK cells through the AKT/mTOR/s6k signaling pathway. Anti-CD160 Antibody (MAT 302) reduces vascular density, normalizes remaining tumor blood vessels, and inhibits tumor growth in melanoma-bearing mice. Anti-CD160 Antibody (MAT 302) can be used in research related to neovascularization, proliferative diabetic retinopathy, and melanoma .

HY-RS17316

Tnfrsf14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf14 Mouse Pre-designed siRNA Set A Tnfrsf14 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P10851

HVEM(14-39)	Apoptosis	Inflammation/Immunology Cancer
HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with BTLA with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of BTLA and *HVEM* in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99961

Tifcemalimab JS004; Icatolimab	CD28	Cancer
Tifcemalimab (JS004; Icatolimab) is a humanized IgG4 monoclonal antibody against BTLA (B and T lymphocyte attenuator). By binding to BTLA, tifcemalimab blocks the interaction of *HVEM-BTLA*, thereby inhibiting the BTLA-mediated inhibitory signaling pathway. Tifcemalimab can be used in research related to squamous cell non-small cell lung cancer .

HY-P992201

Anti-CD160 Antibody (MAT 302) CL1-R2	MHC Apoptosis IFNAR TNF Receptor Interleukin Related Akt mTOR	Cardiovascular Disease Neurological Disease Cancer
Anti-CD160 Antibody (MAT 302) (CL1-R2) is a human monoclonal antibody targeting CD160. Anti-CD160 Antibody (MAT 302) blocks the *CD160-HVEM* protein interaction, inhibits FGF2-mediated renal tubular vascular growth, and induces endothelial cell apoptosis. Anti-CD160 Antibody (MAT 302) targets CD160 on neovascularization to exert anti-angiogenic and vascular normalization effects, trigger the production of IFN-γ, TNF and IL-6 by NK cells, and enhance glucose metabolism of NK cells through the AKT/mTOR/s6k signaling pathway. Anti-CD160 Antibody (MAT 302) reduces vascular density, normalizes remaining tumor blood vessels, and inhibits tumor growth in melanoma-bearing mice. Anti-CD160 Antibody (MAT 302) can be used in research related to neovascularization, proliferative diabetic retinopathy, and melanoma .

Recombinant Proteins Recommended:

HVEM

Species:	Human (11) Rhesus Macaque (2) Mouse (6)
Tag:	His (10) Avi (1) Myc (1) Flag (1) Fc (10)
Source:	HEK293 (14) Sf9 insect cells (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78798

	HVEM/TNFRSF14 Protein, Human (Biotinylated, HEK293, Fc-Avi) TNFRSF14; ATAR; HVEA; HVEM; LIGHTR; TR2; CD270	Human	HEK293
	The HVEM/TNFRSF14 protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-α, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizes the TRAF2-TRAF3 E3 ligase pathway to promote the survival and differentiation of immune cells. HVEM/TNFRSF14 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P73108

	HVEM/TNFRSF14 Protein, Mouse (HEK293, His-Fc) Tumor Necrosis Factor Receptor Superfamily Member 14; TR2; CD270; TNFRSF14; HVEA; HVEM	Mouse	HEK293
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Mouse (HEK293, His-Fc) is a recombinant protein with a C-Terminal Fc label and a C-Terminal His label, is produced in HEK293 cells.

HY-P70184

	HVEM/TNFRSF14 Protein, Rhesus macaque (HEK293, His) rRhTNF receptor superfamily member 14/HVEM, His ; Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM	Rhesus Macaque	HEK293
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Rhesus macaque (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 165 amino acids (L39-V203) and is produced in HEK293 cells.

HY-P71992

	HVEM/TNFRSF14 Protein, Mouse (HEK293, hFc) Tnfrsf14; HVEM; Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD antigen CD270	Mouse	HEK293
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 169 amino acids (Q39-V207) and is produced in HEK293 cells.

HY-P704665

	HVEM/TNFRSF14 Protein, Human (HEK293, mFc) Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM	Human	HEK293
	The HVEM/TNFRSF14 protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-α, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizes the TRAF2-TRAF3 E3 ligase pathway to promote the survival and differentiation of immune cells. HVEM/TNFRSF14 Protein, Human (HEK293, mFc) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P70951

	HVEM/TNFRSF14 Protein, Rhesus macaque (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM	Rhesus Macaque	HEK293
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Rhesus macaque (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 167 amino acids (P37-V203) and is produced in HEK293 cells.

HY-P700452

	HVEM/TNFRSF14 Protein, Human (HEK293, hFc) Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM	Human	HEK293
	The HVEM/TNFRSF14 protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-α, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizes the TRAF2-TRAF3 E3 ligase pathway to promote the survival and differentiation of immune cells. HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70489

	HVEM/TNFRSF14 Protein, Human (HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM	Human	HEK293
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Human (HEK293, His) is a recombinant protein with a C-Terminal His label, It is produced in HEK293 cells.

HY-P7366

	HVEM/TNFRSF14 Protein, Human (sf9, Fc) rHuHVEM, Fc Chimera; TNFRSF14; TR2; CD270; HVEA	Human	Sf9 insect cells
	HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Human (sf9, Fc) is a recombinant protein consisting of 146 amino acids (L39-K184) and is produced in sf9 insect cells.

HY-P78477

	LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) CD258; TNFSF14; HVEM-L; LIGHT; LTg; TR2	Human	HEK293
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) is the extracellular part (S89-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal His- and Flag-tag.

HY-P704400

	LIGHT/TNFSF14 Protein, Mouse (HEK293, His) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Mouse	HEK293
	LIGHT/TNFSF14 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LIGHT/TNFSF14 protein, expressed by HEK293, with N-His tag.

HY-P705412

	LIGHT/TNFSF14 Protein, Human (HEK293, mFc) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Human	HEK293

HY-P73837

	LIGHT/TNFSF14 Protein, Mouse (sf9, His) 2 Publications Verification Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Mouse	Sf9 insect cells
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Mouse (sf9, His) is the extracellular part (D72-V239) of mouse LIGHT/TNFSF14 Protein, produced by Sf9 insect cells, with N-terminal His-tag.

HY-P72522

	LIGHT/TNFSF14 Protein, Human (HEK293, His) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Human	HEK293
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. LIGHT/TNFSF14 Protein, Human (HEK293, His) is produced by HEK293 cells (L83-V240), with N-terminal 6*His-tag.

HY-P73281

	LIGHT/TNFSF14 Protein, Human (HEK293, Fc) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Human	HEK293
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, Fc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with a N-terminal hFc-tag.

HY-P700221AF

	Animal-Free LIGHT/TNFSF14 Protein, Mouse (His) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Mouse	E. coli
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). Animal-Free LIGHT/TNFSF14 Protein, Mouse (His) is the extracellular part (R58-V239) of mouse LIGHT/TNFSF14 Protein, produced by E.coli, with C-terminal His-tag.This product is for cell culture use only.

HY-P73837A

	LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution) Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT	Mouse	Sf9 insect cells
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution) is the extracellular part (D72-V239) of mouse LIGHT/TNFSF14 Protein in solution form, produced by Sf9 insect cells, with N-terminal His-tag.

HY-P700136AF

	Animal-Free LIGHT/TNFSF14 Protein, Human (His) Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD258; HVEML; LIGHT; UNQ391; PRO726;	Human	E. coli
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). Animal-Free LIGHT/TNFSF14 Protein, Human (His) is the extracellular part (R64-V240) of human LIGHT/TNFSF14 Protein, produced by E. coli, with C-terminal His-tag.This product is for cell culture use only.

HY-P72033

	LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc) Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD258; HVEML; LIGHT; UNQ391; PRO726;	Human	HEK293
	LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal hFc- and Myc-tag.

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Tag
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Free Sample	Yes No
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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	ICC/IF (1) WB (1) FC (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2) Biotin (1)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81597

	HVEM Antibody (YA1342) ATAR; CD270; HVEA; HVEM; LIGHTR; TR2	FC, ELISA	Human
	HVEM Antibody (YA1342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HVEM.

HY-P810383

	HVEM Antibody (YA9700) HVEML, ATAR, CD270, CD40 like protein precursor, Herpes virus entry mediator A, Herpesvirus entry mediator A, Herpesvirus entry mediator, Herpesvirus entry mediator ligand, HveA, HVEM	WB, ICC/IF, FC	Human
	HVEM Antibody (YA9700) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to HVEM.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS14806

TNFRSF14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF14 Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17316

Tnfrsf14 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tnfrsf14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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