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Cat. No.: HY-P10851

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HVEM(14-39)

HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with BTLA with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of BTLA and HVEM in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer.

For research use only. We do not sell to patients.

Formula: C₁₁₅H₁₈₂N₃₂O₄₀S₄
Molecular Weight:2781.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HVEM(14-39) Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 2781.13
Formula C₁₁₅H₁₈₂N₃₂O₄₀S₄
Sequence

Ac-Glu-Ser-Cys-Pro-Lys-Cys-Ser-Pro-Gly-Tyr-Arg-Val-Lys-Glu-Ala-Cys-Gly-Glu-Leu-Thr-Gly-Thr-Val-Cys-Glu-Pro-NH2 (Disulfide bridge:Cys3-Cys16;Cys6-Cys24)
Sequence Shortening

Ac-ESCPKCSPGYRVKEACGELTGTVCEP-NH2 (Disulfide bridge:Cys3-Cys16;Cys6-Cys24)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wojciechowicz K, et al. Targeting BTLA with the peptide inhibitor HVEM(14-39) - A new way to restore the activity of T cells in melanoma. Biomed Pharmacother. 2024 Jun;175:116675. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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