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Human African trypanosomiasis

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103056
    DDD85646
    1 Publications Verification

    IMP-366

    		 DNA/RNA Synthesis Parasite Infection
    DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646
  • HY-19910
    Acoziborole
    3 Publications Verification

    SCYX-7158; AN5568

    		 Parasite Infection
    Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .
    Acoziborole
  • HY-120060
    GNF6702

    		Parasite Infection
    GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .
    GNF6702
  • HY-153021
    NMT-IN-1

    		Parasite Infection
    NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
    NMT-IN-1
  • HY-136637
    NPD-001

    		Phosphodiesterase (PDE) Parasite Infection
    NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .
    NPD-001
  • HY-P1759A
    N-CBZ-Phe-Arg-AMC hydrochloride

    Z-FR-AMC hydrochloride

    		 Cathepsin Others
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
    N-CBZ-Phe-Arg-AMC hydrochloride
  • HY-N11173A
    trans-Melilotoside

    		Parasite Infection
    trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria [1] [3].
    trans-Melilotoside
  • HY-155655
    JC-229

    		Parasite Infection
    JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .
    JC-229
  • HY-Q40175
    Antitrypanosomal agent 9

    		Parasite Infection
    Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .
    Antitrypanosomal agent 9
  • HY-169728
    SID 24785302

    		Hexokinase Parasite Infection
    SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection .
    SID 24785302
  • HY-179690
    Antiparasitic agent-30

    		Parasite Adenosine Kinase Infection
    Antiparasitic agent-30 is a potent adenosine kinase TbrAK modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei rhodesiense, while enhancing the activity of recombinant TbrAK(EC50=38 nM, Ka=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) .
    Antiparasitic agent-30
  • HY-W726137
    Potassium 1,2-naphthoquinone-4-sulphonate

    		Drug Intermediate Infection
    Potassium 1,2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC50 of 53 μM. Potassium 1,2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis .
    Potassium 1,2-naphthoquinone-4-sulphonate
  • HY-155732
    NPD-2975

    		Parasite Infection
    NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
    NPD-2975
  • HY-119480
    Megazol

    		Bacterial Infection
    Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
    Megazol
  • HY-151195
    20S Proteasome-IN-4

    		Proteasome Parasite Infection
    20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .
    20S Proteasome-IN-4
  • HY-122382
    Levofuraltadone

    NF-602

    		 Parasite Bacterial Infection
    Levofuraltadone (NF-602) is an antibacterial and antiparasitic agent. Levofuraltadone has anti-trypanosomiasis activity and can be used in the study of human african trypanosomiasis as well as bacterial infections .
    Levofuraltadone
  • HY-155024
    HAT-IN-8

    		Parasite Infection
    HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC50: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .
    HAT-IN-8
  • HY-N12637
    Kagimminol B

    		Parasite Infection
    Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .
    Kagimminol B
  • HY-155025
    Antitrypanosomal agent 14

    		Parasite GSK-3 Infection
    Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC50: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC50 of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis .
    Antitrypanosomal agent 14
  • HY-125084
    NEU617

    		Parasite Infection
    NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC50: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898) .
    NEU617
  • HY-150506
    SPR7

    		Parasite Infection
    SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a Ki of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC50 of 1.65 μM .
    SPR7
  • HY-183529
    Antitrypanosomal agent 31

    		Parasite CDK GSK-3 Infection
    Antitrypanosomal agent 31 is an antitrypanosoma agent with a pEC50 of 6.4. Antitrypanosomal agent 31 inhibits GSK-3β, CDK-2, and CDK-4 with pIC50s of 5.8, 6.9, and 7.1, respectively. Antitrypanosomal agent 31 can be used for the research of human african trypanosomiasis .
    Antitrypanosomal agent 31
  • HY-119480R
    Megazol (Standard)

    		Bacterial Infection
    Megazol (Standard) is the analytical standard of Megazol. This product is intended for research and analytical applications. Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
    Megazol (Standard)
  • HY-180452
    HAT-IN-10

    		Paraptosis Infection
    HAT-IN-10 (Compound 12a) is an anti-human African trypanosomiasis (HAT) agent, with an EC50 value of 0.23 μM for T. brucei. HAT-IN-10 can be used for research on HAT .
    HAT-IN-10
  • HY-N19754
    Cladospirone B

    		Parasite Infection
    Cladospirone B is a secondary metabolite of the endophytic fungus Lasiodiplodia theobromae. Cladospirone B exhibits trypanocidal activity, with a MIC of 17.8 µM against Trypanosoma brucei. Cladospirone B can be used in the research of African human trypanosomiasis (sleeping sickness) .
    Cladospirone B
  • HY-182443
    PEX5-PEX14 PPI-IN-4

    		Parasite Infection
    PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC50 values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease .
    PEX5-PEX14 PPI-IN-4
  • HY-175974
    Antitrypanosomal agent 27

    		Parasite Infection
    Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI50 of 31 nM. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis .
    Antitrypanosomal agent 27
  • HY-103056R
    DDD85646 (Standard)

    IMP-366 (Standard)

    		 Reference Standards DNA/RNA Synthesis Parasite Infection
    DDD85646 (Standard) is the analytical standard of DDD85646 (HY-103056). This product is intended for research and analytical applications. DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646 (Standard)
  • HY-185309
    Anti-Trypanosoma cruzi agent-9

    		Topoisomerase Parasite Infection
    Anti-Trypanosoma cruzi agent-9 is a topoisomerase II inhibitor. Anti-Trypanosoma cruzi agent-9 inhibits the growth of Trypanosoma cruzi and Leishmania donovani .
    Anti-Trypanosoma cruzi agent-9
  • HY-125188
    NEU-4438

    		Parasite DNA/RNA Synthesis AMPK Clathrin Infection
    NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
    NEU-4438

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