3032452-65-3
Chemical Structure
NPD-2975
- CAS No.: 3032452-65-3
- Formula:C14H13FN4O
- Molecular Weight:272.28
InChIKey: OJEVXJSJYBCDSR-UHFFFAOYSA-N
SMILES: O=C1C(NN=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1
Biological Activity: NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively[1].
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NPD-2975 | 98.40% | NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively. | ||||||||||||||||||||
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Keywords
