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Results for "

IAP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IAP (42) SNIPERs (30) Akt (6) AMPK (1) Androgen Receptor (3) Antibiotic (3) Apoptosis (23) Autophagy (3) Bacterial (3) Bcl-2 Family (1) Bcr-Abl (13) Caspase (9) CD47 (3) Drug Derivative (2) Drug Intermediate (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (27) EGFR (1) Estrogen Receptor/ERR (4) FABP (1) FAK (1) FLT3 (1) FXR (2) GLUT (1) HSP (1) Isotope-Labeled Compounds (2) JNK (3) Ligands for E3 Ligase (11) Ligands for Target Protein for PROTAC (12) MDM-2/p53 (1) MHC (3) mTOR (1) NF-κB (3) P-glycoprotein (3) PANoptosis (1) PARP (2) PERK (1) PI3K (4) PROTAC Linkers (2) PROTACs (17) Proteasome (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) RIP kinase (1) Small Interfering RNA (siRNA) (7) SOD (1) Survivin (2) Target Protein Ligand-Linker Conjugates (10) TNF Receptor (1) VEGFR (1) YAP (10)
By Research Areas:	Cancer (130) Infection (5) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (5) siRNAs (7)

151

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: IAP SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15454

Xevinapant 10+ Cited Publications AT-406; Debio 1143; SM-406	IAP Apoptosis	Cancer
Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of *IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with K_i* of 66.4, 1.9, and 5.1 nM, respectively.

HY-101040

Telacebec 5+ Cited Publications Q203; IAP6	Bacterial Antibiotic	Infection
Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

HY-15518

LCL161 Maximum Cited Publications 41 Publications Verification	IAP	Cancer
LCL161 is a *IAP* inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC₅₀s of 35 and 0.4 nM, respectively.

HY-125593

Dasminapant APG-1387	IAP Apoptosis	Cancer
Dasminapant (APG-1387), a bivalent SMAC mimetic and an *IAP* antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma .

HY-15835

CUDC-427 5 Publications Verification GDC-0917	IAP	Cancer
CUDC-427 is a potent second-generation pan-selective *IAP* antagonist, used for treatment of various cancers.

HY-13638

GDC-0152 10+ Cited Publications	IAP	Cancer
GDC-0152 is a potent *IAPs* inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of *ML-IAP* with K_i values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.

HY-P990131

*Anti-Mouse CD47/IAP* Antibody (MIAP301)** 1 Publications Verification	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse *CD47/IAP* IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis .

HY-124181

SM-1295	IAP Apoptosis	Cancer
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K_d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively .

HY-113534

MV1	IAP Apoptosis	Cancer
MV1 is an antagonist of *IAP* (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand .

HY-136269

A 410099.1, amine-Boc hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5) .

HY-P990132

*Anti-Mouse/Rat/Human CD47/IAP* Antibody (MIAP410)**	CD47	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human *CD47/IAP* IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair .

HY-125378

SBP-0636457 SBI-0636457; SB1-0636457	IAP	Cancer
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an *IAP* antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a K_i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers .

HY-111844

PROTAC RAR Degrader-1	PROTACs SNIPERs RAR/RXR	Neurological Disease Metabolic Disease Cancer
PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .

HY-43962

Androgen receptor ligand 3	Ligands for Target Protein for PROTAC Androgen Receptor	Cancer
Androgen receptor ligand 3 is an androgen receptor (AR) ligand. Androgen receptor ligand 3 is linked to an IAP ligand via a linker to form an ERα PROTAC degrader.

HY-111876

SNIPER(TACC3)-1	SNIPERs	Cancer
SNIPER(TACC3)-1 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on *IAP* ligand. SNIPER(TACC3)-1 induces cancer cell death .

HY-130991

K-Ras ligand-Linker Conjugate 6	Target Protein Ligand-Linker Conjugates	Cancer
K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .

HY-151966

TD1092	PROTACs IAP Caspase PANoptosis	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via *IAP* degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-111857

Dasatinib carbaldehyde BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4	Ligands for Target Protein for PROTAC	Cancer
Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-111877

SNIPER(TACC3)-2	SNIPERs	Cancer
SNIPER(TACC3)-2 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on *IAP* ligand. SNIPER(TACC3)-2 induces cancer cell death .

HY-RS02250

CD47 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD47	Others
CD47 Human Pre-designed siRNA Set A contains three designed siRNAs for CD47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD47 Human Pre-designed siRNA Set A CD47 Human Pre-designed siRNA Set A

HY-128809

cIAP1 ligand 2 E3 ligase Ligand 11	Ligands for E3 Ligase	Cancer
cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.

HY-150825

CST530	IAP Ligands for E3 Ligase	Cancer
CST530 is an inhibitor of apoptosis protein (IAP) antagonist. CST530 is an IAP-type Ligands for E3 Ligase. CST530 binds to the BIR3 domain of IAP and interferes with its function, thereby promoting the ubiquitination and degradation of cIAP1. CST530 can be used to prepare PROTACs .

HY-125378A

(7R)-SBP-0636457 (7R)-SBI-0636457; (7R)-SB1-0636457	IAP	Cancer
(7R)-SBP-0636457 is the isomer of SBP-0636457 (HY-125378), and can be used as an experimental control. SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an *IAP* antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a K_i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers .

HY-120434

AEG40826 HGS1029	IAP	Cancer
AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an inhibitor of apoptosis (IAP) inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research .

HY-131188

PROTAC Bcl-xL degrader-1	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an *IAP* E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC₅₀ values of 62 nM and 8.5 μM, respectively .

HY-111848A

PROTAC AR Degrader-4 TFA	SNIPERs PROTACs Androgen Receptor	Cancer
PROTAC AR Degrader-4 comprises a *IAP* ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .

HY-111848

PROTAC AR Degrader-4	SNIPERs PROTACs Androgen Receptor	Cancer
PROTAC AR Degrader-4 comprises a *IAP* ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .

HY-139865

142I5	Apoptosis	Cancer
142I5 is a potent *ML-IAP* Lys-covalent inhibitor with an IC₅₀ value of 11 nM.

HY-111872

SNIPER(ABL)-020	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein .

HY-111840

PROTAC CRABP-II Degrader-1	SNIPERs PROTACs	Cancer
PROTAC CRABP-II Degrader-1 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on *IAP* ligand .

HY-136010

RIP2 Kinase Inhibitor 4	RIP kinase PROTACs	Inflammation/Immunology
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC₅₀ of 8) and inhibits the release of related TNF-α .

HY-111860

SNIPER(ABL)-013	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 20 μM .

HY-111861

SNIPER(ABL)-024	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 5μM .

HY-111850

Bestatin-amido-Me PROTAC IAP binding moiety 1	Ligands for E3 Ligase	Cancer
Bestatin-amido-Me, the Bestatin-based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .

HY-175446

GDC-0152-acetamide	IAP Apoptosis	Cancer
GDC-0152-acetamide is a pan-inhibitor of apoptosis protein (IAP) antagonist. GDC-0152-acetamide induces cIAP1/2 autoubiquitination and degradation, activating the non-canonical NF-κB pathway to promote TNF-α secretion and tumor cell apoptosis. GDC-0152-acetamide is promising for research of ERα-positive breast cancer .

HY-111842

PROTAC CRABP-II Degrader-3	SNIPERs PROTACs	Cancer
PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on *IAP* ligand .

HY-101040A

Telacebec ditosylate Q203 ditosylate; IAP6 ditosylate	Bacterial Antibiotic	Infection
Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

HY-111849

Imatinib carbaldehyde CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1	Ligands for Target Protein for PROTAC	Cancer
Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-118522

TP-110	Proteasome NF-κB Caspase PARP IAP Apoptosis	Cancer
TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc .

HY-131178

HG-7-85-01-NH2	SNIPERs Ligands for Target Protein for PROTAC Bcr-Abl	Cancer
HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-128818

cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs .

HY-177389

IAP ligand 5	Ligands for Target Protein for PROTAC	Cancer
IAP ligand 5 is a *IAP* ligand. IAP ligand 5 can be used to synthesize PROTAC ERα Degrader-2 (HY-111846).

HY-176441

E3 ligase Ligand 66	Ligands for E3 Ligase	Infection
E3 ligase Ligand 66 is an E3 ligase ligand that can be used to recruit IAP proteins. E3 ligase Ligand 66 can be linked to SARS-CoV-2 Mpro ligand 1 (HY-176442) through a linker to form PROTAC BP-198 (HY-176440) .

HY-111853

MV-1-NH-Me PROTAC IAP binding moiety 2	Ligands for E3 Ligase	Cancer
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .

HY-123870

MX107	Survivin IAP NF-κB	Inflammation/Immunology Cancer
MX107 is a selective and potent survivin inhibitor that suppresses triple-negative breast cancer (TNBC) cell proliferation. MX107 induces degradation of survivin and inhibitor-of-apoptosis proteins (IAPs), which inhibits nuclear factor κB (NF-κB) activation induced by DNA damage. MX107 enhances tumoricidal efficacy of genotoxic treatments synergized with chemotherapeutic drugs .

HY-129776

K-Ras ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates	Cancer
K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .

HY-129775

K-Ras ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .

HY-RS00628

ALPI Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ALPI Human Pre-designed siRNA Set A contains three designed siRNAs for ALPI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ALPI Human Pre-designed siRNA Set A ALPI Human Pre-designed siRNA Set A

HY-RS06506

IAPP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IAPP Human Pre-designed siRNA Set A contains three designed siRNAs for IAPP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IAPP Human Pre-designed siRNA Set A IAPP Human Pre-designed siRNA Set A

HY-136272

A 410099.1 amide-PEG3-amine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-PEG3 linker with terminal amine. A 410099.1 amide-PEG3-amine-Boc can conjugates with target protein ligands.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

164 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 164 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L003

Apoptosis Compound Library

3,363 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 3,363 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P11828

Anticancer agent 324	Survivin Caspase Apoptosis	Cancer
Anticancer agent 324 is a Survivin inhibitor. Anticancer agent 324 competitively binds to Survivin’s linker region and triggers proteasomal IAP degradation. Anticancer agent 324 blocks Borealin binding and chromosomal passenger complex formation, and inhibits Survivin-CRM1 nuclear-cytoplasmic transport. Anticancer agent 324 activates extrinsic (caspase-8) and intrinsic (caspase-9) apoptotic pathways, activates executioner caspases-3 and caspases-7, and arrests cell cycle. Anticancer agent 324 can be used for the research of breast cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990131

*Anti-Mouse CD47/IAP* Antibody (MIAP301)** 1 Publications Verification	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse *CD47/IAP* IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis .

HY-P990132

*Anti-Mouse/Rat/Human CD47/IAP* Antibody (MIAP410)**	CD47	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human *CD47/IAP* IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair .

HY-P990188

Anti-Mouse MHC class II (I-A) Antibody (Y-3P)	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P990186

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107738

Guggulsterone Maximum Cited Publications 21 Publications Verification Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-W009141

1-Monopalmitin Glyceryl palmitate	Plants Source Classification	P-glycoprotein IAP PI3K Akt Caspase Apoptosis
1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-N2445

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic *IAP* proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-N6064

Polygalacin D 3 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer Source Classification	Apoptosis IAP
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the *IAP* family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

HY-107738R

Guggulsterone (Standard) Z/E-Guggulsterone (Standard)	Triterpenes Structural Classification Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

HY-W009141R

1-Monopalmitin (Standard) Glyceryl palmitate (Standard)	Plants Source Classification	Reference Standards Apoptosis P-glycoprotein PI3K IAP Caspase Akt
1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin (HY-W009141). This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

Species:	Human (24) Rhesus Macaque (4) Rat (3) Mouse (10) Cynomolgus (5) Rabbit (1) Canine (1)
Tag:	SUMO (1) His (25) Tag Free (4) Avi (13) GST (2) Fc (11)
Source:	HEK293 (34) P. pastoris (2) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71692

	Alkaline Phosphatase/ALPI Protein, Human (His) Alkaline phosphatase intestinal; Glycerophosphatase; IAP	Human	E. coli
	ALPI Proteinas, an alkaline phosphatase, effectively hydrolyzes diverse phosphate compounds. Alkaline Phosphatase/ALPI Protein, Human (His) is the recombinant human-derived ALPI protein, expressed by E. coli , with N-His labeled tag.

HY-P704478

	CD47 Protein, Human (HEK293, His, Avi) CD47; MER6; IAP; OA3	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (HEK293, His, Avi) is the recombinant human-derived CD47 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P78611

	CD47 Protein, Rabbit (HEK293, Fc) CD47; MER6; IAP; OA3	Rabbit	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Rabbit (HEK293, Fc) is the recombinant Rabbit-derived CD47 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD47 Protein, Rabbit (HEK293, Fc) is 121 a.a., with molecular weight of 48-58 kDa.

HY-P78639

	CD47 Protein, Canine (HEK293, His) CD47; MER6; IAP; OA3	Canine	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Canine (HEK293, His) is the recombinant canine-derived CD47 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD47 Protein, Canine (HEK293, His) is 122 a.a., with molecular weight of 27-32 kDa.

HY-P78710

	CD47 Protein, Mouse (HEK293, mFc) CD47; MER6; IAP; OA3	Mouse	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P704477

	CD47 Protein, Human (HEK293, mFc) CD47; MER6; IAP; OA3	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (HEK293, mFc) is the recombinant human-derived CD47 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P705497

	Alkaline Phosphatase/ALPI Protein, Cynomolgus (HEK293, His) Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase	Cynomolgus	HEK293

HY-P72822

	Alkaline Phosphatase/ALPI Protein, Human (HEK293, His) Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase	Human	HEK293
	ALPI Proteinas, an alkaline phosphatase, effectively hydrolyzes diverse phosphate compounds. Alkaline Phosphatase/ALPI Protein, Human (HEK293, His) is the recombinant human-derived ALPI protein, expressed by HEK293 , with C-His labeled tag.

HY-P700395

	Alkaline Phosphatase/ALPI Protein, Rat (HEK293, His) Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase	Rat	HEK293
	The ALPI protein, an alkaline phosphatase enzyme, hydrolyzes phosphate compounds, demonstrating enzymatic activity in breaking down different phosphate molecules. Alkaline Phosphatase/ALPI Protein, Rat (HEK293, His) is the recombinant rat-derived ALPI protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P705250

	CD47 Protein, Mouse (Biotinylated, HEK293, Fc-Avi) CD47; MER6; IAP; OA3	Mouse	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-Avi, C-Fc labeled tag.

HY-P78561

	CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi) CD47; MER6; IAP; OA3	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived CD47 protein, expressed by HEK293 , with C-mFc, C-Avi labeled tag.

HY-P78908

	CD47 Protein, Human (Biotinylated, HEK293, hFc-Avi) CD47; MER6; IAP; OA3	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (Biotinylated, HEK293, hFc-Avi) is the recombinant human-derived CD47 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P701266

	FITC-Labeled CD47 Protein, Human (HEK293, His) CD47; MER6; IAP; OA3	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. FITC-Labeled CD47 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD47 protein, expressed by HEK293 , with His labeled tag.

HY-P78907

	CD47 Protein, Mouse (Biotinylated, HEK293, His-Avi) CD47; MER6; IAP; OA3	Mouse	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700394

	Alkaline Phosphatase/ALPI Protein, Human (HEK293, N-His) Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase	Human	HEK293
	ALPI Proteinas, an alkaline phosphatase, effectively hydrolyzes diverse phosphate compounds. Alkaline Phosphatase/ALPI Protein, Human (HEK293, N-His) is the recombinant human-derived ALPI protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P78711

	CD47 Protein, Mouse (HEK293, hFc) CD47; MER6; IAP; OA3	Mouse	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72918

	CD47 Protein, Mouse (HEK293, His) Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Mouse	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins. It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74289

	CD47 Protein, Mouse (HEK293, solution) Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Mouse	HEK293
	The CD47 protein, also known as integrin-associated protein (IAP), is an immune checkpoint protein. CD47 binds to membrane integrins and binds ligands platelet reaction-protein-1 (TSP-1) and signal regulatory protein alpha (SIRP伪). CD47 is a potential therapeutic target for some cancers and is also used to treat pulmonary fibrosis. CD47 Protein, Mouse (HEK293, solution) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with tag free.

HY-P75401

	CD47 Protein, Rat (HEK293, His) Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Rat	HEK293
	The CD47 protein acts as a THBS1 receptor and regulates integrin signaling, promoting cell-cell interactions. It plays a role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, immune regulation, and memory formation. CD47 Protein, Rat (HEK293, His) is the recombinant rat-derived CD47 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72917

	CD47 Protein, Human (HEK293) 1 Publications Verification Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (HEK293) is the recombinant human-derived CD47 protein, expressed by HEK293 , with tag free.

HY-P78095

	CD47 Protein, Human (Biotinylated, HEK293, His-Avi) CD47 glycoprotein; CD47 molecule; CD47; IAP; OA3; MER6	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD47 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75402

	CD47 Protein, Rat (HEK293, Fc) Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Rat	HEK293
	The CD47 protein acts as a THBS1 receptor and regulates integrin signaling, promoting cell-cell interactions. It plays a role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, immune regulation, and memory formation. CD47 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD47 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700682

	CD47 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) CD47 glycoprotein; CD47 molecule; CD47; IAP; OA3; MER6	Rhesus Macaque;Cynomolgus	HEK293
	CD47 is a leukocyte surface antigen, and high expression of CD47 helps tumors escape. CD47 inhibition leads to the activation of CD103+ dendritic cells, which leads to the recruitment and activation of natural killer cells and inhibits cancer development. CD47 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived CD47 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72359

	CD47 Protein, Human (Biotinylated, HEK293, Avi-His) Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; IAP; MER6	Human	HEK293
	CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. CD47 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived CD47 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P70820

	CD47 Protein, Mouse (140a.a, HEK293, His) Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6	Mouse	HEK293
	The CD47 protein is an adhesive multifunctional protein that coordinates cell-cell interactions, serves as a THBS1 receptor, and regulates integrin signaling through heterotrimeric G proteins.It plays a key role in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cell self-renewal, immune regulation, and memory formation. CD47 Protein, Mouse (140a.a, HEK293, His) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700653

	Alkaline Phosphatase/ALPI Protein, Mouse (HEK293, His) IAP; Akp2; ALPI; APTNAP; AP-TNAP; FLJ40094; FLJ93059; HOPS; MGC161443; TNAP; TNSALP	Mouse	HEK293
	The alkaline phosphatase/ALPI protein is critical for phosphatase, metal ion binding, and homodimerization activities, affecting BMP stimulation responses. It is strategically located outside the plasma membrane and its predicted activity emphasizes cellular function. Alkaline Phosphatase/ALPI Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alkaline Phosphatase/ALPI protein, expressed by HEK293 , with C-His labeled tag.

HY-P72240

	IAPP Protein, Human (GST) Amylin; DAP; Diabetes associated peptide; Diabetes-associated peptide; IAP; IAPP; IAPP_HUMAN; Insulinoma amyloid peptide; Islet amyloid polypeptide diabetes associated peptide, amylin; Islet amyloid polypeptide	Human	E. coli
	The IAPP protein selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, affecting glucose metabolism without affecting adipocytes. IAPP interacts with IDE (insulin-degrading enzyme) and insulin (INS) to form homodimers, affecting their fibril formation. IAPP Protein, Human (GST) is the recombinant human-derived IAPP protein, expressed by E. coli , with N-GST labeled tag.

HY-P705178

	CD47 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) rRhIntegrin-associated protein/CD47, Fc; Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6	Cynomolgus;Rhesus Macaque	HEK293

HY-P705179

	CD47 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His-Avi) rRhIntegrin-associated protein/CD47, Fc; Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6	Rhesus Macaque;Cynomolgus	HEK293

HY-P704531

	IAPP Protein, Human (P. pastoris, His) Amylin; DAP; Diabetes associated peptide; Diabetes-associated peptide; IAP; IAPP; IAPP_HUMAN; Insulinoma amyloid peptide; Islet amyloid polypeptide diabetes associated peptide, amylin; Islet amyloid polypeptide	Human	P. pastoris
	The IAPP protein selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, affecting glucose metabolism without affecting adipocytes. IAPP interacts with IDE (insulin-degrading enzyme) and insulin (INS) to form homodimers, affecting their fibril formation. IAPP Protein, Human (P. pastoris, His) is the recombinant human-derived IAPP protein, expressed by P. pastoris, with N-6*His labeled tag.

HY-P7831

	CD47 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) rRhIntegrin-associated protein/CD47, Fc; Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6	Rhesus Macaque;Cynomolgus	HEK293
	CD47 is a leukocyte surface antigen, and high expression of CD47 helps tumors escape. CD47 inhibition leads to the activation of CD103+ dendritic cells, which leads to the recruitment and activation of natural killer cells and inhibits cancer development. CD47 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD47 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71717

	Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His) Birc5; Api4; IAP4Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; TIAP	Mouse	P. pastoris
	Apoptosis inhibitor 4/Birc5 has the dual effects of promoting cell proliferation and inhibiting apoptosis. As an important component of the chromosomal channel protein complex (CPC), Birc5 coordinates chromosome alignment and segregation during mitosis and cytokinesis. Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Apoptosis inhibitor 4/Birc5 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P7335

	CD47 Protein, Human (HEK293, Fc) rHuCD47, Fc Chimera; MER6; IAP; OA3	Human	HEK293
	CD47 Protein, Human (HEK293, Fc) is a polypeptide chain with the C-terminal human IgG1 Fc fragment produced in HEK293 cells. CD47 is a prominent target in cancer immunotherapy.

HY-P74289A

	CD47 Protein, Mouse (HEK293) Leukocyte Surface Antigen CD47; IAP; CD47; MER6	Mouse	HEK293
	The CD47 protein, also known as integrin-associated protein (IAP), is an immune checkpoint protein. CD47 binds to membrane integrins and binds ligands platelet reaction-protein-1 (TSP-1) and signal regulatory protein alpha (SIRP伪). CD47 is a potential therapeutic target for some cancers and is also used to treat pulmonary fibrosis. CD47 Protein, Mouse (HEK293) is the recombinant mouse-derived CD47 protein, expressed by HEK293 , with tag free.

HY-P7336

	CD47 Protein, Human (HEK293, His) rHuCD47, His; CD47; MER6; IAP; OA3	Human	HEK293
	CD47 Protein, Human (HEK293, His) is a polypeptide chain with His tag produced in HEK293 cells. CD47 is a prominent target in cancer immunotherapy.

HY-P73485

	XIAP Protein, Human (Avi) E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4	Human	E. coli
	XIAP protein is a multifunctional regulator that controls apoptosis, inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor, it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive. XIAP Protein, Human (Avi) is the recombinant human-derived XIAP protein, expressed by E. coli , with C-Avi labeled tag.

HY-P73537

	XIAP Protein, Human (His) E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4	Human	E. coli
	XIAP protein is a multifunctional regulator that controls apoptosis, inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor, it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive. XIAP Protein, Human (His) is the recombinant human-derived XIAP protein, expressed by E. coli , with N-His labeled tag.

HY-P77065

	Livin/BIRC7 Protein, Human (His) Baculoviral IAP repeat-containing protein 7; KIAP; MLIAP; RNF50	Human	E. coli
	Livin/BIRC7 is an apoptosis regulator that coordinates pro- and anti-apoptotic activities and is critical for apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic functions include inhibition of CASP3, CASP7 and CASP9, as well as E3 ubiquitin protein ligase activity. Livin/BIRC7 Protein, Human (His) is the recombinant human-derived Livin/BIRC7 protein, expressed by E. coli , with C-His labeled tag.

HY-P704995

	XIAP Protein, Human (GST) E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4	Human	E. coli

HY-P7645

	BIRC5 Protein, Human rHuBIRC5; Baculoviral IAP Repeat-Containing Protein 5; Apoptosis Inhibitor 4; BIRC5; Survivin; BIRC5	Human	E. coli
	BIRC5 Protein, Human, a protein in the intrinsic apoptotic pathway that interacts with XIAP and DIABLO leading to caspase-3 and caspase-9 inactivation. BIRC5 (survivin) is also involved in stabilizing the microtubule-kinetochore dynamics.

HY-P702495

	BIRC5 Protein, Human (His-SUMO) rHuBIRC5; Baculoviral IAP Repeat-Containing Protein 5; Apoptosis Inhibitor 4; BIRC5; Survivin; BIRC5	Human	E. coli
	The BIRC5 protein has dual roles in cell proliferation and prevention of apoptosis. It is an important CPC component and guides chromosome alignment and segregation during mitosis. It directs CPC movement, contributes to central spindle organization, and recruits CPC to centromeres. BIRC5 Protein, Human (His-SUMO) is the recombinant human-derived BIRC5 protein, expressed by E. coli , with labeled tag.

HY-P77769

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Monomer Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

HY-P77770

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Tetramer Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

HY-P700944

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

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Cat. No.	Product Name	Chemical Structure

HY-107447S

N-Deshydroxyethyl Dasatinib-d8
N-Deshydroxyethyl Dasatinib-d₈ is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL .

HY-W009141S

1-Monopalmitin-d31

1-Monopalmitin-d₃₁ (Glyceryl palmitate-d₃₁) is the deuterium labeled 1-Monopalmitin (HY-W009141). 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

Host:	Mouse (9) Rabbit (15)
Reactivity:	Human (21) Rat (10) Mouse (9) Monkey (3)
Application:	IHC-P (11) ICC/IF (8) IP (6) WB (23) FC (4) ELISA (6)
Isotype:	IgG (13) IgG1 (5) IgG/Kappa (2) IgG2a (2)
Conjugation:	Non-conjugated (24) Biotin (9)
Clonality:	polyclonal (1) Monoclonal (14) Recombinant (6)
Modification:	Unmodified (15)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84037

	Intestinal Alkaline Phosphatase Antibody(YA3734) IAP; ALPI	WB, FC, ELISA	Human
	Intestinal Alkaline Phosphatase Antibody(YA3734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Intestinal Alkaline Phosphatase.

HY-P84037A

	Intestinal Alkaline Phosphatase Antibody(YA3734)(PBS only) IAP; ALPI	WB, FC, ELISA	Human
	Intestinal Alkaline Phosphatase Antibody(YA3734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Intestinal Alkaline Phosphatase.

HY-P84512

	CD47 Antibody (YA4209) IAP; OA3; MER6	WB, IHC-P, FC, ELISA	Human
	CD47 Antibody (YA4209) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD47.

HY-P84512A

	CD47 Antibody (YA4209)(PBS only) IAP; OA3; MER6	WB, IHC-P, FC, ELISA	Human
	CD47 Antibody (YA4209) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD47.

HY-P81814

	Intestinal Alkaline Phosphatase Antibody (YA1559) Alpi; Glycerophosphatase; IAP	WB, IHC-P	Human
	Intestinal Alkaline Phosphatase Antibody (YA1559) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Intestinal Alkaline Phosphatase.

HY-P82755

	cIAP1 Antibody (YA2500) cIAP1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; API1; IAP2; MIHB; RNF48	WB, ICC/IF	Human
	cIAP1 Antibody (YA2500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cIAP1.

HY-P82755A

	cIAP1 Antibody (YA2500)(PBS only) cIAP1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; API1; IAP2; MIHB; RNF48	WB, ICC/IF	Human
	cIAP1 Antibody (YA2500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cIAP1.

HY-P810632

	intestinal alkaline phosphatase Antibody (YA9894) Alpi; Glycerophosphatase; IAP	WB	Human, Mouse
	intestinal alkaline phosphatase Antibody (YA9894) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to intestinal alkaline phosphatase.

HY-P810633

	intestinal alkaline phosphatase Antibody (YA9895) Alpi; Glycerophosphatase; IAP	IHC-P	Human, Mouse, Rat
	intestinal alkaline phosphatase Antibody (YA9895) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to intestinal alkaline phosphatase.

HY-P810634

	intestinal alkaline phosphatase Antibody (YA9896) Alpi; Glycerophosphatase; IAP	WB, IHC-P	Human
	intestinal alkaline phosphatase Antibody (YA9896) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to intestinal alkaline phosphatase.

HY-P86214

	XIAP Antibody (YA5906) XIAP; API3; BIRC4; IAP3; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked I	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	XIAP Antibody (YA5906) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XIAP.

HY-P86537

	Survivin/BIRC5 Antibody (YA6229) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Survivin/BIRC5 Antibody (YA6229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin/BIRC5.

HY-P80906

	Survivin/BIRC5 Antibody (YA665) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin	WB, IHC-P	Human, Rat
	Survivin/BIRC5 Antibody (YA665) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Survivin/BIRC5.

HY-P85731

	Survivin/BIRC5 Antibody (YA5423) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin	WB, IHC-P, ICC/IF	Human, Rat
	Survivin/BIRC5 Antibody (YA5423) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Survivin/BIRC5.

HY-P86950

	Livin Antibody (YA6643) Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney inhibitor of apoptosis protein antibody; Livin antibody; Livin inhibitor of apotosis antibody; Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney inhibitor of apoptosis protein antibody; Livin antibody; Livin inhibitor of apotosis antibody; Melanoma inhibitor of apoptosis protein antibody; ML IAP antibody; ML-IAP antibody; MLIAP antibody; RING finger protein 50 antibody; RNF 50 antibody; RNF50 antibody;	WB, IHC-P, IP	Human
	Livin Antibody (YA6643) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Livin.

HY-P80618

	cIAP2 Antibody (YA795) cIAP2; AIP1; API2; BIRC3; CIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2	WB	Human, Monkey
	cIAP2 Antibody (YA795) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to cIAP2.

HY-P85568

	cIAP2 Antibody (YA5260) AIP 1; AIP1; API 2; API2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; CIAP 2; CIAP 2; CIAP2; HAIP 1; HAIP1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.	WB	Human, Monkey
	cIAP2 Antibody (YA5260) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to cIAP2.

HY-P87097

	Survivin Antibody (YA6790) API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody;	WB, IHC-P, IP	Mouse, Rat
	Survivin Antibody (YA6790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin.

HY-P80618A

	cIAP2 Antibody (YA795)(PBS only) cIAP2; AIP1; API2; BIRC3; CIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2	WB	Human, Monkey
	cIAP2 Antibody (YA795) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to cIAP2.

HY-P810445

	NAIP Antibody Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein, NAIP, BIRC1	WB, IHC-P, ICC/IF	Human
	NAIP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NAIP.

HY-P80589

	Caspase-7 Antibody (YA561) Mch3; CMH-1; mCASP-7; AI314680; ICE-IAP3; caspase-7	WB, ICC/IF, IP	Mouse, Rat
	Caspase-7 Antibody (YA561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-7.

HY-P82684

	XIAP Antibody (YA2429) API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3	WB	Human, Mouse, Rat
	XIAP Antibody (YA2429) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XIAP.

HY-P80589A

	Caspase-7 Antibody (YA561)(PBS only) Mch3; CMH-1; mCASP-7; AI314680; ICE-IAP3; caspase-7	WB, ICC/IF, IP	Mouse, Rat
	Caspase-7 Antibody (YA561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-7.

HY-P82684A

	XIAP Antibody (YA2429)(PBS only) API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3	WB	Human, Mouse, Rat
	XIAP Antibody (YA2429) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XIAP.

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Cat. No.	Product Name		Classification

HY-181530

IAP ligand 6		PROTAC Synthesis
IAP ligand 6 (A250) is an IAP ligand with a K_a value of 0.1 μM for the human XIAP BIR3 domain. IAP ligand 6 binds to the XIAP BIR3 domain and serves as an alkynylpyridine scaffold for the preparation of TEAD degraders that recruit IAP. IAP ligand 6 is applicable to research related to mesothelioma .

HY-181534

*PROTAC TEAD1/IAP* degrader-1**		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective TEAD1 and cIAP1 PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the TEAD-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2		PROTAC Synthesis
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent TEAD1/IAP PROTAC degrader with anti-cancer activity .

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