1562375-46-5
1562375-46-5
Chemical Structure
SM-1295
- CAS No.: 1562375-46-5
- Formula:C29H36BrN5O4
- Molecular Weight:598.53
IUPAC Name: (5S,8S,10aR)-N-(4-bromobenzyl)-5-((S)-2-(methylamino)propanamido)-6-oxo-3-(2-phenylacetyl)decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
InChIKey: SOTHWYAWZKSXSA-CTZQYXLCSA-N
SMILES: O=C([C@@H]1CC[C@@](CCN(C(CC2=CC=CC=C2)=O)C[C@@H]3NC([C@@H](NC)C)=O)([H])N1C3=O)NCC4=CC=C(Br)C=C4
Biological Activity: SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SM-1295 | 98.71% | SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively. | ||||||||||||||||||||
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References
- [1]. Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9(4):994-1002. [Content Brief]
- [2]. Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62(12):5750-5772. [Content Brief]
Keywords
