873652-48-3
873652-48-3
Chemical Structure
GDC-0152
- CAS No.: 873652-48-3
- Formula:C25H34N6O3S
- Molecular Weight:498.64
IUPAC Name: (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide
InChIKey: WZRFLSDVFPIXOV-LRQRDZAKSA-N
SMILES: O=C(N1[C@H](C(NC2=C(C3=CC=CC=C3)N=NS2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
Biological Activity: GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GDC-0152 | 99.70% | GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-15835CUDC-427 -
Similarity Score 0.57
HY-15519LBW242 -
Similarity Score 0.50
HY-138059SM-433 -
Similarity Score 0.49
HY-P4528Ala-Phe-Pro-βNA -
Similarity Score 0.48
HY-125128Glp-Pro-Val-pNA -
Similarity Score 0.48
HY-P4461Ala-Ala-Pro-pNA -
Similarity Score 0.46
HY-P5993MeOSuc-Ala-Ala-Pro-Val-4-MNA -
Similarity Score 0.46
HY-P4490Suc-Ala-Pro-pNA -
Similarity Score 0.46
HY-139656cIAP1 ligand 4 -
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