1. Apoptosis
  2. Apoptosis
    IAP
  3. Polygalacin D

Polygalacin D 

Cat. No.: HY-N6064
Handling Instructions

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

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Polygalacin D Chemical Structure

Polygalacin D Chemical Structure

CAS No. : 66663-91-0

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Description

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]

IC50 & Target

IC50: IAP[1]

In Vitro

Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1].
Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].
Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1].

Cell Proliferation Assay[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM, 40µM
Incubation Time: 48 hours
Result: Inhibited the proliferation of NSCLC cell lines.

Apoptosis Analysis[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM
Incubation Time: 48 hours
Result: Induced apoptosis of NSCLC cell lines.

Western Blot Analysis[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM
Incubation Time: 48 hours
Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression.
Molecular Weight

1209.32

Formula

C₅₇H₉₂O₂₇

CAS No.

66663-91-0

SMILES

O[[email protected]]([[email protected]@H]([[email protected]@H](O[[email protected]@]1([H])[[email protected]@H]([[email protected]]([[email protected]](O)CO1)O[[email protected]@]2([H])[[email protected]@H]([[email protected]](CO)(O)CO2)O)O)[[email protected]](C)O3)O)[[email protected]]3([H])O[[email protected]]([[email protected]]([[email protected]@H](O)CO4)O)[[email protected]@H]4OC([[email protected]]56[[email protected]](CC(C)(C)CC6)([H])C7=CC[[email protected]@]([[email protected]@]8([[email protected]@]([[email protected]](C)([[email protected]@H](O[[email protected]]9([H])O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]9O)CO)[[email protected]@H](O)C8)CO)([H])CC%10)C)([H])[[email protected]]%10(C)[[email protected]]7(C)C[[email protected]]5O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Polygalacin D
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