Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
LAG-3-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "LAG-3-IN-1" in MCE Product Catalog:
Cat. No.: HY-176814
LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a KD of 0.41 μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research .
4
Cat. No.: HY-P99141
Target:
Research Areas:
Cat. No.: HY-162811
CAS No.: 1830484-40-6
LAG-3 biner 1 (compound 3) is a small molecule ligand (Kd=1.23 μM) for the immune checkpoint lymphocyte activation gene 3 (LAG-3). LAG-3 biner 1 can be used in the research of cancer diagnosis targeting LAG-3 .
Cat. No.: HY-179060
LAG-3 PROTAC-1 is a lymphocyte activation gene-3 (LAG-3) PROTAC degrader with a DC50 of 0.27 μM. LAG-3 PROTAC-1 induces the formation of a ternary complex with LAG-3 and CRL4 CRBN, promoting proteasomal degradation. LAG-3 PROTAC-1 is applicable for cancer-related research .
Cat. No.: HY-P990700
CAS No.: 2648839-43-2
Synonyms: RO-7247669; RG-6139
Target:
Research Areas:
Cat. No.: HY-179061
CAS No.: 3009770-86-6
Research Areas:
LAG-3 degrader 1 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as LAG-3 PROTAC-1 (HY-179060). LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with anti-tumor activity .
Cat. No.: HY-164308
CAS No.: 852846-00-5
Target:
Research Areas:
SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies .
Cat. No.: HY-P990912
CAS No.: 2852680-10-3
Synonyms: AK-129
Target:
Research Areas:
Cat. No.: HY-P990204
Target:
Research Areas:
Cat. No.: HY-180900
CAS No.: 2249005-28-3
Target:
Research Areas:
Z3071585108 is a small molecule binder of the LAG-3 D1 domain with Kd values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3 .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
