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20 Results for "
LTA4 hydrolase
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "LTA4 hydrolase" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .
Synonyms: LTA4H-IN-1
Target:
Research Areas:
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .
Cat. No.: HY-112621
CAS No.: 73466-12-3
Synonyms: LTA4 methyl ester
Target:
Research Areas:
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
Cat. No.: HY-W097753
CAS No.: 834-14-0
Synonyms: 4-Methoxydiphenylmethane
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4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases .
Cat. No.: HY-10828
CAS No.: 179022-08-3
Target:
Research Areas:
SC-57461 is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .
Cat. No.: HY-118795
CAS No.: 262451-89-8
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SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis .
Cat. No.: HY-103226R
CAS No.: 423169-68-0
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SC-57461A (Standard) is the analytical standard of SC-57461A (HY-103226). This product is intended for research and analytical applications. SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .
Cat. No.: HY-115500
CAS No.: 1206514-50-2
Research Areas:
PL265 is an orally active dual enkephalinase inhibitor. PL265 is a prodrug of PL254, which can simultaneously and efficiently inhibit neutral endopeptidase (Neprilysin) and Aminopeptidase N. PL265 can effectively protect and significantly increase the local concentration of enkephalins (such as Met-Enkephalin and Leu-Enkephalin) released by cells at the pain or inflammation sites, thereby activating μ and δ opioid receptors to produce a potent analgesic effect. PL254 can also inhibit leukotriene A4 hydrolase (LTA4H), which may contribute to its additional anti-inflammatory effect by reducing the production of pro-inflammatory mediator leukotriene B4 (LTB4). PL265 can be used in non-addictive chronic pain research .
Cat. No.: HY-162710
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Research Areas:
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models .
Cat. No.: HY-P70277
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTA4H; Leukotriene A-4 hydrolase; Leukotriene A4 hydrolase; CDNA FLJ51712, Moderately Similar To Leukotriene A-4 hydrolase; LTA-4 hydrolase; Testicular Secretory Protein Li 27; Tripeptide Aminopeptidase LTA4H; LTA4H Protein; Leukotriene A(4) hydrolase; LT
Species:
Human
Source:
HEK293
Cat. No.: HY-P74776
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LTA4H; Leukotriene A-4 hydrolase; Leukotriene A4 hydrolase; CDNA FLJ51712, Moderately Similar To Leukotriene A-4 hydrolase; LTA-4 hydrolase; Testicular Secretory Protein Li 27; Tripeptide Aminopeptidase LTA4H; LTA4H Protein; Leukotriene A(4) hydrolase; LT
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P73275
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTA4H; Leukotriene A-4 hydrolase; Leukotriene A4 hydrolase; CDNA FLJ51712, Moderately Similar To Leukotriene A-4 hydrolase; LTA-4 hydrolase; Testicular Secretory Protein Li 27; Tripeptide Aminopeptidase LTA4H; LTA4H Protein; Leukotriene A(4) hydrolase; LT
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-162015
CAS No.: 2851480-52-7
Target:
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LTA4H-IN-2 (compound (S)-2 ) is an orally active inhibitor of Leukotriene A4 Hydrolase, with an IC50 of <3 nM .
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JNJ-26993135 is a selective leukotriene A4 hydrolase (LTA4H) inhibitor with the IC50 value of 11 nM .
Cat. No.: HY-137298A
CAS No.: 2619563-79-8
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LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LYS006 hydrochloride can be used for the research of inflammatory and autoimmune disorders .
Cat. No.: HY-156960
CAS No.: 1191044-42-4
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Research Areas:
JNJ-40929837 is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .
Cat. No.: HY-156960A
CAS No.: 1191044-47-9
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Research Areas:
JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .
Cat. No.: HY-10826
CAS No.: 929916-05-2
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Research Areas:
DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a Kd of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke .
Cat. No.: HY-W004291S
CAS No.: 39756-40-6
Synonyms: Methyl icosanoate-d39
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
