1 Result for "

Ligusticum cycloprolactam

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Ligusticum cycloprolactam" in MCE Product Catalog:

Ligusticum cycloprolactam
Ligusticum cycloprolactam
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Cat. No.: HY-N17383
CAS No.: 2283387-37-9
Category:  

Natural Products Plants Umbelliferae Echinacea angustifolia DC.

Target:  

Toll-like Receptor (TLR) NF-κB Collagen Interleukin Related Cadherin NOD-like Receptor (NLR) TGF-β Receptor FXR Apoptosis

Ligusticum cycloprolactam is a potent, orally active, and CNS-penetrant TLR4/NF-κB inhibitor, exhibiting anti-inflammatory and neuroprotective activity. Ligusticum cycloprolactam reduces FPR1 expression, inhibits NLRP3 inflammasome, TLR4/NF-κB, hepatic MAPK and TGF-β signaling, and selectively activates hepatic FXR. Ligusticum cycloprolactam attenuates pro-inflammatory mediator production, enhances anti-inflammatory cytokine secretion, regulates renal uric acid transporters, and preserves intestinal microbiota composition. Ligusticum cycloprolactam can be used for the research of ischemic stroke, hyperuricemic nephropathy, neuroinflammation, and metabolic dysfunction-associated fatty liver disease .
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