28 Results for "

Lithocholic acid

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "Lithocholic acid" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-B0172
CAS No.: 434-13-9
Synonyms: 3α-Hydroxy-5β-cholanic acid
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-B0172A
CAS No.: 2276-93-9
Synonyms: 3β-Hydroxy-5α-cholanic acid
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-B0172B
CAS No.: 1534-35-6
Synonyms: 3β-Hydroxy-5β-cholanic acid; 3-EpiLithocholic acid; β-Lithocholic acid
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-143712
CAS No.: 2276-94-0
Purity:  98.70%
Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-B0172S
CAS No.: 83701-16-0
Synonyms: 3α-Hydroxy-5β-cholanic acid-d4
Lithocholic acid-d4 is the deuterium labeled Lithocholic acid, which is a toxic secondary bile acid .
loading...
    loading...
Cat. No.: HY-W587530
CAS No.: 2393-61-5
Synonyms: 6-KetoLithocholic acid
Research Areas:  

Endocrinology

6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis, especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases .
loading...
    loading...
Cat. No.: HY-B0172R
CAS No.: 434-13-9
Synonyms: 3α-Hydroxy-5β-cholanic acid (Standard)
Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .
loading...
    loading...
Cat. No.: HY-113238A
CAS No.: 64936-81-8
Purity:  99.93%
Synonyms: SulfoLithocholic acid disodium; LCAS disodium
Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+, and 0.88 μM and 0.97 μM in the presence of Zn 2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .
loading...
    loading...
Cat. No.: HY-173496
CAS No.: 192876-13-4
Research Areas:  

Cancer

ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC) .
loading...
    loading...
Cat. No.: HY-169393
CAS No.: 135013-42-2
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

N-Butyl lithocholic acid is a derivative of the secondary bile acid Lithocholic acid (HY-B0172) .
loading...
    loading...
Cat. No.: HY-177795
CAS No.: 6868-73-1
Synonyms: 3,6-Diketo-LCA
Target:  

Drug Derivative

Research Areas:  

Others

5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA) (HY-B0172). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR .
loading...
    loading...
Cat. No.: HY-118276
CAS No.: 1053-37-8
Target:  

Drug Derivative

Research Areas:  

Cancer

Lithocholenic acid, a derivative of Lithocholic acid, possesses anti-tumor activity .
loading...
    loading...
Cat. No.: HY-113238S1
Lithocholic acid 3-sulfate-d4(sodium salt) is the deuterium labeled Lithocholic acid 3-sulfate .
loading...
    loading...
Cat. No.: HY-B0172S1
CAS No.: 52840-06-9
Synonyms: 3α-Hydroxy-5β-cholanic acid-d5
Lithocholic acid-d5 is deuterium labeled Lithocholic acid.
loading...
    loading...
Cat. No.: HY-113238F
Purity:  90.01%
Synonyms: FITC-SulfoLithocholic acid
FITC-Lithocholic acid 3-sulfate (FITC-Sulfolithocholic acid) is a FITC-labeled Lithocholic acid 3-sulfate, which is a sulfated biliary metabolite. Lithocholic acid 3-sulfate selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate can be used for the research of pathogenesis of cholestatic liver diseases .
loading...
    loading...
Cat. No.: HY-143712S1
Synonyms: 3α-hydoxy-5α-Cholaoic acid-d4, allo-LCA-d4
Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .
loading...
    loading...
Cat. No.: HY-113238AS
Purity:  99.68%
Synonyms: SulfoLithocholic acid-d4 disodium
Lithocholic acid 3-sulfate-d4 (disodium) is the deuterium labeled Lithocholic acid 3-sulfate disodium .
loading...
    loading...
Cat. No.: HY-B0172BR
CAS No.: 1534-35-6
Synonyms: 3β-Hydroxy-5β-cholanic acid (Standard); 3-EpiLithocholic acid (Standard); β-Lithocholic acid (Standard)
Isolithocholic acid (Standard) is the analytical standard of Isolithocholic acid. This product is intended for research and analytical applications. Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate[1][2].
loading...
    loading...
Cat. No.: HY-B0172AR
CAS No.: 2276-93-9
Synonyms: 3β-Hydroxy-5α-cholanic acid (Standard)
Isoallolithocholic acid (Standard) is the analytical standard of Isoallolithocholic acid. This product is intended for research and analytical applications. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1].
loading...
    loading...
Cat. No.: HY-169826
CAS No.: 2095154-73-5
Research Areas:  

Others

N-Lithocholyl-L-Leucine is a bile acid conjugate composed of Lithocholic acid (HY-B0172) and L-leucine (HY-N0486). N-Lithocholyl-L-Leucine can be used to form hydrogels .
loading...
    loading...