Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
350 Results for "
N-terminal
" in MedChemExpress (MCE) Product Catalog:
Products (350)
350 Results for "N-terminal" in MCE Product Catalog:
27
27 Publications Verification
Target:
Research Areas:
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells .
27
27 Publications Verification
Cat. No.: HY-108239
CAS No.: 1392399-03-9
Target:
Research Areas:
BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294 trihydrochloride, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 trihydrochloride has antitumor activity in recurrent tumor cells .
9
9 Cited Publications
Target:
Research Areas:
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) . BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM .
8
8 Cited Publications
Cat. No.: HY-P2333
CAS No.: 533902-29-3
Target:
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P2333A
Target:
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P1098
CAS No.: 151988-33-9
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P1098A
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P1098B
Target:
Research Areas:
4
JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively .
4
4 Cited Publications
Cat. No.: HY-P70700A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STING1; HSTING; Prev. TMEM173; N-terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner; Transmembrane Protein 173; Stimulator Of Interferon Response CGAMP Interactor-DeltaC; STING; Stimulator Of Interferon Response CGAMP Interactor-Delt
4
4 Cited Publications
Cat. No.: HY-P80728
Synonyms: AI849689 antibody;
c Jun N terminal kinase 1 antibody;
C-JUN kinase 1 antibody;
c-Jun N-terminal kinase 1 antibody;
EC 2.7.11.24 antibody;
JNK 1 antibody;
JNK antibody;
JNK-46 antibody;
JNK1A2 antibody;
JNK21B1/2 antibody;
MAP kinase 8 antibody;
MAPK 8 antibody;
mapk8 antibody;
Mitogen activated protein kinase 8 antibody;
MK08_HUMAN antibody;
p54 gamma antibody;
Prkm8 antibody;
Protein kinase JNK1 antibody;
Protein kinase, mitogen-activated, 8 antibody;
SAPK 1 antibody;
SAPK gamma antibody;
SAPK1 antibody;
Stress-activated protein kinase 1 antibody
4
3
3 Cited Publications
Target:
Research Areas:
CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis .
3
Target:
Research Areas:
3
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P7409
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SHH; Shh Unprocessed N-terminal Signaling And C-terminal Autoprocessing Domains; Prev. HLP3; Sonic Hedgehog Protein; Prev. HPE3; ShhNC; MCOPCB5; Sonic Hedgehog (Drosophila) Homolog; SMMCI; Sonic Hedgehog Homolog; TPTPS; Hedgehog Protein; HHG1; HHG-1; TPT
2
2 Cited Publications
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90 .
2
2
2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
