8 Results for "

N-terminal epitope

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "N-terminal epitope" in MCE Product Catalog:

Cat. No.: HY-P99859
CAS No.: 1931944-80-7
Synonyms: LY3002813

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research .
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Cat. No.: HY-P99551
CAS No.: 1374419-41-6
Synonyms: KBSA301; AR-301

Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
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Cat. No.: HY-P0329
CAS No.: 339988-16-8
Target:  

Inhibitory Antibodies

Research Areas:  

Others

X-press Tag Peptide is a tag peptide used for protein purification. X-press Tag is also an N-terminal leader peptide; this N-terminal peptide contains a polyhistidine sequence, the Xpress epitope (part of bacteriophage T7 gene 10 protein) and an enterokinase cleavage site. Anti-Xpress antibodies recognize the Xpress epitope sequence found in this leader peptide.
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Cat. No.: HY-P1854
CAS No.: 147529-30-4
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism .
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Cat. No.: HY-P99859A
CAS No.: 1931944-80-7
Synonyms: LY3002813 (powder)

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Donanemab (LY3002813) (powder) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab (powder) has the potential for early Alzheimer's disease research .
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Cat. No.: HY-P991781

Target:  

CXCR

Research Areas:  

Cancer

Anti-Mouse CXCR6 Antibody (Cx6Mab-1) is a monoclonal antibody targeting mouse CXC chemokine receptor 6 (mCXCR6), with a KD of 1.7 nM against CHO/mCXCR6-overexpressing cells. Anti-Mouse CXCR6 Antibody (Cx6Mab-1) binds to the N-terminal domain epitope of mCXCR6 containing Ser8, Ala9, Leu10, Tyr11, Gly13 and His14, and interacts with both overexpressed and endogenous forms of the receptor. Anti-Mouse CXCR6 Antibody (Cx6Mab-1) can be used in studies related to mouse lymphoma .
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Cat. No.: HY-P992457

Research Areas:  

Cancer

SAR444200 is a nanobody targeting GPC3 (glypican-3) and TCRαβ (T-cell receptor αβ). The KD of SAR444200 for human GPC3 is 0.023 nM, and its KD for human TCRαβ is 5.2 nM. SAR444200 mediates T cell-dependent cytotoxicity, and exhibits high selectivity and killing activity against GPC3-positive tumor cells. SAR444200 binds to GPC3 in a dual-epitope manner, and binds to TCRαβ via its N-terminal nanobody, forming an artificial immunological synapse between T cells and tumor cells. SAR444200 can be used in studies of GPC3+ solid tumors, including liver cancer, lung squamous cell carcinoma and melanoma .
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Cat. No.: HY-P991782

Target:  

CCR

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse CCR8 Antibody (C8Mab-2) is an antibody targeting mouse CCR8. Anti-Mouse CCR8 Antibody (C8Mab-2) induces antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis to eliminate CCR8-expressing cells. Anti-Mouse CCR8 Antibody (C8Mab-2) eliminates regulatory T cells in the tumor microenvironment, increases CD8 + T cell infiltration and inhibits tumor growth. Anti-Mouse CCR8 Antibody (C8Mab-2) recognizes the N-terminal amino acid region 1-33 of mouse CCR8, in which Thr20 serves as the core binding epitope amino acid. Anti-Mouse CCR8 Antibody (C8Mab-2) is applicable to research related to colon cancer, breast cancer and bladder cancer .
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