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Cat. No.: HY-P99859A

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Donanemab (powder)

(Synonyms: LY3002813 (powder))

Donanemab (LY3002813) (powder) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab (powder) has the potential for early Alzheimer's disease research.

For research use only. We do not sell to patients.

CAS No.: 1931944-80-7
Molecular Weight:145.36 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Donanemab (powder) Chemical Structure

CAS No.: 1931944-80-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Donanemab is a humanized IgG1 antibody directed at an N-terminal pyroglutamate Aβ epitope that is present only in established plaques. Donanemab is specific for this epitope and shows no off-target binding to other Aβ species, neurotransmitters, or their receptors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1931944-80-7
Molecular Weight 145.36 kDa
Synonyms

LY3002813 (powder)
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Stephen Loucian Lowe, et al. Donanemab (LY3002813) dose-escalation study in Alzheimer's disease. Alzheimers Dement (N Y). 2021 Feb 14;7(1):e12112. [Content Brief]

[2]. Mark A Mintun, et al. Donanemab in Early Alzheimer's Disease. N Engl J Med. 2021 May 6;384(18):1691-1704. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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