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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
NCoA1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "NCoA1" in MCE Product Catalog:
Cat. No.: HY-RS09089
Target:
Research Areas:
NCOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for NCOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22672
Target:
Research Areas:
Ncoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS29186
Target:
Research Areas:
Ncoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-146288
CAS No.: 2978788-07-5
Target:
Research Areas:
LXR agonist 2 (compound 18rr) is a potent LXR (liver X receptor) agonist. LXR agonist 2 can stabilize NCOA1 (co-activator), leading to LXR agonism [1].
Cat. No.: HY-173033
CAS No.: 2530027-71-3
Research Areas:
MI-883 is orally active constitutive androstane receptor (CAR) (EC50 of 73 nM) agonist and pregnane X Receptor (PXR) (IC50 of 100 nM) antagonist. MI-883 binds to CAR and PXR ligand-binding domains, promotes CAR LBD assembly, activates CAR3 variant, stimulates CAR cytoplasmic-nuclear translocation, upregulates CAR target genes, recruits coactivators NCOA1, NCOA2, NCOA3, inhibits basal and agonist-induced PXR activation, downregulates PXR target genes, disrupts PXR-NCOR2 interaction, blocks agonist-mediated PXR-NCOA1 recruitment. MI-883 reduces plasma total cholesterol, LDL cholesterol, and hepatic free cholesterol levels, increases fecal bile acid excretion, regulates genes involved in xenobiotic metabolism, cholesterol homeostasis, and bile acid homeostasis. MI-883 exhibits metabolic stability, liver-predominant distribution, a safety profile with no observed toxicity, and does not stimulate human hepatocyte hypertrophy or hyperplasia. MI-883 can be used for the research of diet-induced hypercholesterolemia [1].
Cat. No.: HY-189199
CAS No.: 3093981-26-8
Research Areas:
SARS-CoV-2-IN-124 is an antiviral compound. SARS-CoV-2-IN-124 directly binds to NCOA1 and promotes its lysosome-dependent degradation. SARS-CoV-2-IN-124 downregulates the expression of lipogenic enzymes FASN and SCD1. SARS-CoV-2-IN-124 inhibits SARS-CoV-2 replication in multiple cell lines. SARS-CoV-2-IN-124 can be used for research related to SARS-CoV-2 infection [1].
Cat. No.: HY-160126
CAS No.: 2154373-60-9
27-Norcholestenoic acid is an inverse agonist of LXRβ and LXRα that decreases basal luciferase activity and inhibits agonist-induced transactivation. 27-Norcholestenoic acid induces conformational changes in the AF-2 domain that favor corepressor over coactivator recruitment, thereby destabilizing the active receptor conformation. 27-Norcholestenoic acid downregulates FASN and SREBP-1a/c gene expression [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
