2 Results for "

NRAS-mutant melanoma

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NRAS-mutant melanoma" in MCE Product Catalog:

Cat. No.: HY-12847
CAS No.: 1163719-91-2
Target:  

Raf Src Apoptosis

Domaines de recherche:  

Cancer

CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and NRAS mutant melanomas. CCT241161 also exhibits anticancer cell proliferative activity .
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Cat. No.: HY-159846S
Synonyms: FCN-159-d
Luvometinib-d (FCN-159-d) is the deuterated-labeled Luvometinib (HY-159846). Luvometinib is an orally potent MEK1/2 inhibitor. Luvometinib selectively blocks the MAPK signaling pathway by forming a ternary complex with MEKase and ATP, thereby reducing the phosphorylation level of ERK. Luvometinib induces cell cycle arrest and apoptosis, and inhibits cancer cell proliferation. Luvometinib can be used in relevant research on various solid tumors including melanoma, non-small cell lung cancer, colon cancer, and acute myeloid leukemia .
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