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Results for "

PAM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adenosine Receptor (5) Akt (2) Amyloid-β (1) Apoptosis (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (7) Calcium Channel (1) Cannabinoid Receptor (3) CaSR (4) CD44 (1) Cholinesterase (ChE) (4) COX (6) Cytochrome P450 (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Dopamine Receptor (6) Drug Metabolite (2) E1/E2/E3 Enzyme (1) EAAT (1) Endogenous Metabolite (7) ERK (7) GABA Receptor (22) GCGR (2) GLP Receptor (6) GPR68 (1) Guanylate Cyclase (1) Histone Methyltransferase (2) HSP (2) iGluR (8) IKK (2) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (6) mAChR (23) Melanocortin Receptor (6) mGluR (41) nAChR (10) NAMPT (1) NF-κB (3) NO Synthase (2) Opioid Receptor (4) P-glycoprotein (1) p38 MAPK (2) Parasite (4) PERK (2) PINK1/Parkin (1) PKC (2) Reactive Oxygen Species (ROS) (2) Reference Standards (8) Ser/Thr Protease (1) Sigma Receptor (5) Small Interfering RNA (siRNA) (9) Toll-like Receptor (TLR) (10) TRP Channel (1) Tyrosinase (1) YAP (1)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1180A

Pam3CSK4 TFA 15+ Cited Publications PAM3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-108471

CU-CPT22 10+ Cited Publications	Toll-like Receptor (TLR)	Cancer
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam₃CSK₄) binding to TLR1/2 with a K_i of 0.41 µM. CU-CPT22 blocks Pam₃CSK₄-induced TLR1/2 activation with an IC₅₀ of 0.58 µM .

HY-111052

AZD7325	GABA Receptor Cytochrome P450	Neurological Disease Inflammation/Immunology
AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (K_i=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes . AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro . AZD7325 has the potential for the investigation of anxiety and dravet syndrome . PAM: positive allosteric modulator.

HY-112146

MMG-11 5 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-W115727B

Polyacrylamide,Anion,Mw 18 million PAM,Anion,Mw 18 million	Biochemical Assay Reagents	Others
Polyacrylamide,Anion,Mw 18 million (PAM,Anion,Mw 18 million) is a multifunctional high molecular weight anionic polyacrylamide copolymer. The anionic properties of Polyacrylamide,Anion,Mw 18 million enable it to be used as a flocculant to achieve charge neutralization and aggregation, while its high molecular weight properties provide viscoelastic properties for fluid applications. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-B1200

Pralidoxime chloride 2 Publications Verification 2-PAM chloride	Cholinesterase (ChE)	Neurological Disease
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .

HY-P1181A

Pam2CSK4 TFA 1 Publications Verification	Toll-like Receptor (TLR) NO Synthase IKK Akt PKC NF-κB p38 MAPK Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pam2CSK4 TFA is a TLR2 agonist. Pam2CSK4 TFA induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 TFA activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 TFA expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 TFA acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 TFA can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis .

HY-P1180

Pam3CSK4 PAM3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-165613

Pam2Cys Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine	Toll-like Receptor (TLR) Influenza Virus NF-κB	Infection Inflammation/Immunology
Pam2Cys (Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine) is a TLR2 agonist and immunostimulant. Pam2Cys binds to TLR2 to activate dendritic cells and trigger the TLR2-dependent NF-κB signaling pathway. Pam2Cys also induces dendritic cell maturation by upregulating the expression of cell surface MHC II molecules. Pam2Cys activates innate immune signaling pathways, drives pro-inflammatory and antimicrobial responses, enhances the expression of macrophage activation markers, increases phagocytic activity, induces the release of IL-12 and pro-inflammatory cytokines, and polarizes macrophages into a pro-inflammatory, antimicrobial phenotype without interfering with IL-10-induced macrophage polarization. Pam2Cys also serves as the lipid moiety in synthetic lipopeptide vaccines and possesses self-adjuvant properties. Pam2Cys enhances the immunogenicity of conjugated peptide segments and induces cellular and humoral immune responses. However, it does not activate CD4 T cells in mouse splenocyte cultures when used alone. Pam2Cys activates pulmonary TLR2 signaling pathways, triggers innate immune responses, recruits neutrophils and macrophages, induces the secretion of various cytokines, alleviates symptoms and damages associated with influenza A virus infection in mice without impairing adaptive immunity. Pam2Cys can be used in studies related to tuberculosis and influenza A virus infection .

HY-W115727E

Polyacrylamide,average Mn 150000 PAM,average Mn 150000	Biochemical Assay Reagents	Others
Polyacrylamide, average Mn 150000 (PAM, average Mn 150000) is a versatile, high-molecular-weight polyacrylamide copolymer. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-120874

Darigabat PF-06372865; CVL-865	GABA Receptor	Neurological Disease
Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABA_A positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABA_A receptors containing α1/α2/α3/α5 subunits (K_is of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy .

HY-124419

RO0711401 2 Publications Verification	mGluR	Neurological Disease
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC₅₀ of 56 nM .

HY-W115727A

Polyacrylamide,Anion,Mw 14-16 million PAM,Anion,Mw 14-16 million	Biochemical Assay Reagents	Others
Polyacrylamide, Anion, Mw 14-16 million is a multifunctional high molecular weight anionic polyacrylamide copolymer. The anionic properties of Polyacrylamide, Anion, Mw 14-16 million enable it to be used as a flocculant to achieve charge neutralization and aggregation, while its high molecular weight properties provide viscoelastic properties for fluid applications. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, achieve controlled release as a drug carrier, respond to temperature/pH stimulation as a smart material, and can also be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical embedding, covalent bonding or chemical cross-linking. Polyacrylamide can be used in biomedical engineering, environmental management and industrial applications .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR) NO Synthase IKK Akt PKC NF-κB p38 MAPK Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pam2CSK4 is a TLR2 agonist. Pam2CSK4 induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis .

HY-129086

BPAM344	iGluR	Neurological Disease
BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM) .

HY-120613

BMS-986187	Opioid Receptor	Neurological Disease
BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC₅₀ of 0.03 μM and a pK_B of 6.02 (～1 μM). BMS-986187 has no observable PAM activity at the μ-receptor (EC₅₀=3 μM) .

HY-18654

ADX88178 1 Publications Verification	mGluR	Neurological Disease
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC₅₀ of 4 nM for human mGluR4.

HY-W141789

Pam3-Cys-OH	Biochemical Assay Reagents	Others
Pam3-Cys-OH is a lipoamino acid .

HY-131004

CB2R PAM	Cannabinoid Receptor	Neurological Disease
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain .

HY-120530

JNJ-46281222	mGluR	Neurological Disease
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (K_d = 1.7 nM) and a high modulatory potency (pEC₅₀ = 7.71) .

HY-120023

VU0453595 2 Publications Verification	mAChR	Neurological Disease
VU0453595 is a highly selective, systemically active M₁ positive allosteric modulator (PAM, EC₅₀=2140 nM) for the research of schizophrenia .

HY-143312

V-0219	GLP Receptor	Metabolic Disease
V-0219 (Compound 9) is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). V-0219 can be used for obesity-associated diabetes research .

HY-W115727D

Polyacrylamide,average Mn 40000 PAM,average Mn 40000	Biochemical Assay Reagents	Others
Polyacrylamide (PAM), average M_n 40000 is a versatile, high-molecular-weight polyacrylamide copolymer. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-103475

GS39783	GABA Receptor	Neurological Disease
GS39783 is a positive allosteric modulator (PAM) of GABA_BR. Positive modulation of the GABA_BR can be used for the research of Nicotine addiction .

HY-12439

ML380 1 Publications Verification	mAChR	Neurological Disease
ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC₅₀s of 190 and 610 nM for human and rat M5, respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR .

HY-113346

Tetrahydrodeoxycorticosterone Tetrahydro-11-deoxycorticosterone	GABA Receptor Endogenous Metabolite	Neurological Disease
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABA_A receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties .

HY-136190

*TRPC6-PAM-C20*	TRP Channel	Neurological Disease
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca ²⁺ concentrations ([Ca ²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals .

HY-141515

BMS-986121	Opioid Receptor	Neurological Disease
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs .

HY-122819

Calindol hydrochloride	CaSR	Cardiovascular Disease
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-124821

VA012	5-HT Receptor	Neurological Disease Metabolic Disease
VA012 (compound 11) is a positive allosteric modulator (PAM) of the serotonin 5-HT_2C receptor. VA012 reduces food intake and body weight gain without causing CNS-related malaise during subchronic administration. VA012 can be utilized in obesity research .

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-173396

VU0467319 VU319	mAChR	Neurological Disease
VU0467319 (Compound VU319) is a highly selective and blood-brain-permeable, orally active M1 positive allosteric modulator (PAM) (EC₅₀: 492 nM). VU0467319 is selective (EC₅₀ > 30 μM) versus M2-5 for both human and rat. VU0467319 improves cognitive impairment in Alzheimer's disease (AD) through central M1 muscarinic receptors. VU0467319 does not induce cholinergic adverse reactions and has potential in AD research .

HY-112146A

MMG-11 quarterhydrate 5 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 μM for Pam₃CSK₄-induced hTLR2/1 and 5.7 μM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-P1405

Pam3CSK4-Biotin PAM3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P1180B

Pam3CSK4 trihydrochloride PAM3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents	Others
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-116463

E1R	Sigma Receptor	Neurological Disease
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity .

HY-I0673

Flucofuron	Apoptosis	Infection Inflammation/Immunology
Flucofuron exhibits high efficacy against trophozoites of both N. fowleri strains (ATCC 30808 : IC₅₀ = 2.58 μM and ATCC 30215: IC₅₀ = 2.47 μM), being even active against the resistant cyst stage (IC₅₀ = 0.88 μM). Flucofuron can induce cell apoptosis. Flucofuron can be used for the researches of infection and inflammation, such as Primary amoebic meningoencephalitis (PAM) .

HY-100605

VU0483605	mGluR	Others
VU0483605 is a potent and brain-penetrated mGlu₁ receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu₁ PAM activity at both human and rat, with EC₅₀ values of 390 and 356 nM, respectively .

HY-RS10011

PAM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAM Human Pre-designed siRNA Set A contains three designed siRNAs for PAM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAM Human Pre-designed siRNA Set A PAM Human Pre-designed siRNA Set A

HY-120004

PF-06827443	mAChR	Infection
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion .

HY-121806

VU0486846	mAChR	Neurological Disease
VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity .

HY-118179

VU0486321	mGluR	Neurological Disease
VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

HY-101841

LY 2033298	mAChR	Neurological Disease
LY 2033298 is a selective positive allosteric modulator of the muscarinic M₄ receptor. LY 2033298 can be used in the study of psychiatric disorders .

HY-15476

VU 0364439	mGluR	Neurological Disease
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

HY-14419

TCN238	mGluR	Neurological Disease
TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC₅₀ of 1 μM .

HY-119078

VU0080241	mGluR	Neurological Disease
VU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC₅₀ of 4.6 μM .

Cat. No.	Product Name

HY-L170

Allosteric Modulators (AMs) Compound Library

246 compounds

An emerging drug design method is based on the secondary binding site effect, where small molecule drugs are designed to bind to secondary binding sites on target biomolecules rather than primary orthomorphic sites. Successful potential drugs (known as allosteric modulators) will be able to bind to allosteric sites and remotely alter (or modify) the conformation of the main orthosteric binding sites of biological targets. Allosteric modulators (AMs) are ligands of proteins that act through binding sites different from natural (orthosteric) ligand sites. AMs are relatively small, more lipophilic, and more rigid compounds. The binding efficacy of AMs with their targets is often slightly lower. AMs are divided into positive AMs (PAMs) and negative AMs (NAMs). AMs are ideal drug targets because they can fine-tune receptor activity while preserving the spatial and temporal signal transduction characteristics of endogenous ligands, resulting in fewer targeted side effects, improved subtype selectivity, and better promotion of biased signal transduction than normal ligands.

MCE designs a unique collection of 246 small allosteric modulators. It is a good tool to be used for research on metabolize, cancer and other diseases.

Cat. No.	Product Name	Type

HY-W115727B

Polyacrylamide,Anion,Mw 18 million

PAM,Anion,Mw 18 million

Biochemical Assay Reagents

Polyacrylamide,Anion,Mw 18 million (PAM,Anion,Mw 18 million) is a multifunctional high molecular weight anionic polyacrylamide copolymer. The anionic properties of Polyacrylamide,Anion,Mw 18 million enable it to be used as a flocculant to achieve charge neutralization and aggregation, while its high molecular weight properties provide viscoelastic properties for fluid applications. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-W115727E

Polyacrylamide,average Mn 150000

PAM,average Mn 150000

Biochemical Assay Reagents

Polyacrylamide, average Mn 150000 (PAM, average Mn 150000) is a versatile, high-molecular-weight polyacrylamide copolymer. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-W115727A

Polyacrylamide,Anion,Mw 14-16 million

PAM,Anion,Mw 14-16 million

Biochemical Assay Reagents

Polyacrylamide, Anion, Mw 14-16 million is a multifunctional high molecular weight anionic polyacrylamide copolymer. The anionic properties of Polyacrylamide, Anion, Mw 14-16 million enable it to be used as a flocculant to achieve charge neutralization and aggregation, while its high molecular weight properties provide viscoelastic properties for fluid applications. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, achieve controlled release as a drug carrier, respond to temperature/pH stimulation as a smart material, and can also be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical embedding, covalent bonding or chemical cross-linking. Polyacrylamide can be used in biomedical engineering, environmental management and industrial applications .

HY-W115727D

Polyacrylamide,average Mn 40000

PAM,average Mn 40000

Biochemical Assay Reagents

Polyacrylamide (PAM), average M_n 40000 is a versatile, high-molecular-weight polyacrylamide copolymer. Polyacrylamide series materials can maintain enzyme activity in enzyme immobilization, act as drug carriers to achieve controlled release, serve as smart materials responding to temperature/pH stimuli, and be used for in vitro toxin adsorption and soft tissue filling through mechanisms such as physical entrapment, covalent binding or chemical crosslinking. Polyacrylamide finds applications in biomedical engineering, environmental management and industrial applications .

HY-P1180B

Pam3CSK4 trihydrochloride PAM3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P1180A

Pam3CSK4 TFA 15+ Cited Publications PAM3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P1181A

Pam2CSK4 TFA 1 Publications Verification	Toll-like Receptor (TLR) NO Synthase IKK Akt PKC NF-κB p38 MAPK Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pam2CSK4 TFA is a TLR2 agonist. Pam2CSK4 TFA induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 TFA activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 TFA expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 TFA acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 TFA can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis .

HY-P1180

Pam3CSK4 PAM3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR) NO Synthase IKK Akt PKC NF-κB p38 MAPK Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pam2CSK4 is a TLR2 agonist. Pam2CSK4 induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis .

HY-W141789

Pam3-Cys-OH	Biochemical Assay Reagents	Others
Pam3-Cys-OH is a lipoamino acid .

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-P1405

Pam3CSK4-Biotin PAM3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P1180B

Pam3CSK4 trihydrochloride PAM3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents	Others
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-P1405A

Pam3CSK4-Biotin TFA PAM3Cys-Ser-(Lys)4-Biotin TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin (Pam3Cys-Ser-(Lys)4-Biotin) TFA is biotinylated Pam3CSK4. Pam3CSK4-Biotin TFA is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P5352

Hyaluronan-IN-1	CD44	Inflammation/Immunology Cancer
Hyaluronan-IN-1 (Pep-1) is a Hyaluronan inhibitor with a K_d value of 1.65 μM. Hyaluronan-IN-1 blocks CD44-dependent cell adhesion. Hyaluronan-IN-1 inhibits cell adhesion to hyaluronan substrates. Hyaluronan-IN-1 suppresses the development of contact hypersensitivity in mice by blocking the homing process of inflammatory cells to the skin. Hyaluronan-IN-1 also inhibits responses during the sensitization phase. Hyaluronan-IN-1 reduces lung metastasis of melanoma and prolongs the survival of mice. Hyaluronan-IN-1 can be used in research related to contact hypersensitivity, chronic skin inflammation, and melanoma .

HY-P4802

Pam3-Cys-Ala-Gly	Bacterial	Inflammation/Immunology
Pam3-Cys-Ala-Gly, a synthetic bacterial lipopeptide, is a potent macrophage and B cell activator .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113320

Etiocholanolone 5β-Androsterone	Microorganisms Endogenous metabolite Steroids Source Classification	GABA Receptor Endogenous Metabolite
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity . Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABA_A receptor than its enantiomer form .

HY-N0754

Eupalinolide A	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	YAP HSP Reactive Oxygen Species (ROS) ERK Autophagy Apoptosis Tyrosinase DNA/RNA Synthesis
Eupalinolide A is a Yes-associated protein (YAP) degrader and HSP70 inducer. Eupalinolide A inhibits osteogenic differentiation of tendon-derived stem cells (TDSCs). Eupalinolide A induces autophagy in hepatocellular carcinoma cells via activating the ROS/ERK signaling pathway. Eupalinolide A protects PAM212 cells from UVB-, Menadione (HY-B0332)-, or heat shock-induced apoptosis. Eupalinolide A alleviates trauma-induced heterotopic ossification (HO) of Achilles tendon and inhibits growth of MHCC97-L and HCCLM3 hepatocellular carcinoma xenograft tumors in mice. Eupalinolide A can be used for the study of traumatic heterotopic ossification of tendons and hepatocellular carcinoma .

HY-113346

Tetrahydrodeoxycorticosterone Tetrahydro-11-deoxycorticosterone	Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	GABA Receptor Endogenous Metabolite
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABA_A receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties .

Species:	Human (3) Rat (2) Mouse (2)
Tag:	His (4) Tag Free (2) Fc (3)
Source:	HEK293 (7) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73732

	PAM Protein, Human (HEK293, Fc) Peptidyl-glycine alpha-amidating monooxygenase; PAM; PHM; PAL	Human	HEK293
	The PAM protein is a bifunctional enzyme that coordinates the α-amidation process, which is critical for the biosynthesis of neuropeptides and endocrine peptides. The peptidyl α-hydroxylating monooxygenase (PHM) domain hydroxylates the C-terminal glycine, and the peptidylglycine amide glycolate lyase (PAL) domain cleaves the NC-α bond, producing α-amidated peptides. PAM Protein, Human (HEK293, Fc) is the recombinant human-derived PAM protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73731

	PAM Protein, Human (HEK293, His) Peptidyl-glycine alpha-amidating monooxygenase; PAM; PHM; PAL	Human	HEK293
	The PAM protein is a bifunctional enzyme that coordinates the α-amidation process, which is critical for the biosynthesis of neuropeptides and endocrine peptides. The peptidyl α-hydroxylating monooxygenase (PHM) domain hydroxylates the C-terminal glycine, and the peptidylglycine amide glycolate lyase (PAL) domain cleaves the NC-α bond, producing α-amidated peptides. PAM Protein, Human (HEK293, His) is the recombinant human-derived PAM protein, expressed by HEK293 , with C-His labeled tag.

HY-P71366

	TIM-14 Protein, S.cerevisiae Mitochondrial import inner membrane translocase subunit TIM14; Presequencetranslocated associated motor subunit PAM18; PAM18; TIM14	Others	E. coli
	The TIM-14 protein is an important component of the PAM complex and is required for the transport of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix using ATP. TIM-14 Protein, S.cerevisiae is the recombinant TIM-14 protein, expressed by E. coli , with tag free.

HY-P71367

	TIM-16 Protein, S. cerevisiae Mitochondrial import inner membrane translocase subunit TIM16; Presequence translocated-associated motor subunit PAM16; PAM16; TIM16	Others	E. coli
	TIM-16 protein is an important component of the PAM complex, which uses ATP to promote the transfer of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix. TIM-16 Protein, S. cerevisiae is the recombinant TIM-16 protein, expressed by E. coli , with tag free.

HY-P78322

	JAM-A/CD321 Protein, Mouse (HEK293, His) JAM-A; JAM-1; CD321; JAM; JCAM; JCAM1; KAT; PAM-1; F11 receptor; F11R; PAM-1KAT	Mouse	HEK293
	The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions and is present at primitive cell junctions where it recruits PARD3.This association may hinder PARD3-JAM1 interaction and thus tight junction assembly.JAM-A/CD321 Protein, Mouse (HEK293, His) is the recombinant mouse-derived JAM-A/CD321 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73853

	JAM-A/CD321 Protein, Rat (HEK293, His) Junctional Adhesion Molecule A; JAM-A; JAM-1; PAM-1; CD321; F11R; JCAM	Rat	HEK293
	The JAM-A/CD321 protein is critical for the formation of tight junctions in epithelial cells, participating in early junction development and recruiting PARD3. However, the formation of PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thus preventing tight junction assembly. JAM-A/CD321 Protein, Rat (HEK293, His) is the recombinant rat-derived JAM-A/CD321 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73854

	JAM-A/CD321 Protein, Rat (HEK293, Fc) Junctional Adhesion Molecule A; JAM-A; JAM-1; PAM-1; CD321; F11R; JCAM	Rat	HEK293
	The JAM-A/CD321 protein is critical for the formation of tight junctions in epithelial cells, participating in early junction development and recruiting PARD3. However, the formation of PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thus preventing tight junction assembly. JAM-A/CD321 Protein, Rat (HEK293, Fc) is the recombinant rat-derived JAM-A/CD321 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73855

	JAM-A/CD321 Protein, Mouse (HEK293, Fc) Junctional Adhesion Molecule A; JAM-A; JAM-1; PAM-1; CD321; F11R; JCAM	Mouse	HEK293
	The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions and is present at primitive cell junctions where it recruits PARD3.This association may hinder PARD3-JAM1 interaction and thus tight junction assembly.JAM-A/CD321 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived JAM-A/CD321 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70948

	JAM-A/CD321 Protein, Human (HEK293, His) Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM	Human	HEK293
	The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions, is present in early junction development, and recruits PARD3. Binding of the PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thereby impeding tight junction assembly. JAM-A/CD321 Protein, Human (HEK293, His) is the recombinant human-derived JAM-A/CD321 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-113346S

Tetrahydrodeoxycorticosterone-d3 1 Publications Verification
Tetrahydrodeoxycorticosterone-d₃ is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties .

HY-113320S

Etiocholanolone-d5
Etiocholanolone-d₅ is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity . Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABAA?receptor than its?enantiomer form .

HY-173251S

ENX-101
ENX-101 is an orally active (GABA_A) receptor partial positive allosteric modulator (PAM). ENX-101 is selective to α2β2γ2L (EC₅₀ = 0.76 nM), α2β3γ2L (EC₅₀ = 0.61 nM), α3 (EC₅₀ = 1.97 nM), α5 (EC₅₀ = 0.85 nM) subunits of GABA receptor. ENX-101 possesses antiseizure activity in several animal models .

HY-W777503

Calindol hydrochloride-13C,D2
Calindol hydrochloride- ¹³C,d₂ is the deuterium and ¹³C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-113320S1

Etiocholanolone-d2
Etiocholanolone-d₂ is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity . Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABAA?receptor than its?enantiomer form .

HY-B1456AS

Fenoprofen-13C6 sodium hydrate

Fenoprofen- ¹³C₆ (LILLY-53858- ¹³C₆) sodium hydrate is the ¹³C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-167922S

Heptadecanoyl L-carnitine-d3 HCl

Heptadecanoyl L-carnitine-d₃ HCl is the deuterium labeled (R,R,S)-GAT107 (HY-167922). (R,R,S)-GAT107 is a fully agonistic positive modulator of α7 nicotinic receptors with significant biological activity. Its activity is entirely present in its (+)-isomer 1b, while (-)-isomer 1a does not affect its activity when used together. Studies have shown that (R,R,S)-GAT107 is the most potent ago-PAM for α7 nicotinic receptors currently known and has the potential for further in vivo evaluation .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (5) IP (2) WB (3) FC (3) ELISA (2)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84900

	Junctional Adhesion Molecule 1 Antibody (YA4597) F11R; JAM; KAT; JAM1; JAMA; JCAM; PAM-1	IHC-P, ICC/IF, FC, ELISA	Human
	Junctional Adhesion Molecule 1 Antibody (YA4597) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Junctional Adhesion Molecule 1.

HY-P84900A

	Junctional Adhesion Molecule 1 Antibody (YA4597)(PBS only) F11R; JAM; KAT; JAM1; JAMA; JCAM; PAM-1	IHC-P, ICC/IF, FC, ELISA	Human
	Junctional Adhesion Molecule 1 Antibody (YA4597) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Junctional Adhesion Molecule 1.

HY-P86968

	MYCBP2 Antibody (YA6661) AU023734 antibody; AW107953 antibody; AW546647 antibody; C130061D10Rik antibody; DKFZp686M08244 antibody; FLJ10106 antibody; FLJ13826 antibody; FLJ21597 antibody; FLJ21646 antibody; KIAA0916 antibody; AU023734 antibody; AW107953 antibody; AW546647 antibody; C130061D10Rik antibody; DKFZp686M08244 antibody; FLJ10106 antibody; FLJ13826 antibody; FLJ21597 antibody; FLJ21646 antibody; KIAA0916 antibody; MYC binding protein 2 antibody; PAM antibody; PAM, highwire, rpm 1 antibody; PAM/highwire/rpm-1 protein antibody; Phr1 antibody; Protein associated with Myc antibody; R75243 antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	MYCBP2 Antibody (YA6661) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYCBP2.

HY-P83280

	Junctional Adhesion Molecule 1 Antibody (YA3025) F11R; JAM1; JCAM; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321	WB, ICC/IF, IP	Human
	Junctional Adhesion Molecule 1 Antibody (YA3025) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Junctional Adhesion Molecule 1.

HY-P83280A

	Junctional Adhesion Molecule 1 Antibody (YA3025)(PBS only) F11R; JAM1; JCAM; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321	WB, ICC/IF, IP	Human
	Junctional Adhesion Molecule 1 Antibody (YA3025) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Junctional Adhesion Molecule 1.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-118022

VU0361747		Alkynes
VU0361747 is a potent and selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM). VU0361737 has neuroprotective effect. VU0361737 significantly reverses Amphetamine-induced hyperlocomotion in vivo .

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