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MitoBloCK-10 

Cat. No.: HY-115467
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MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70.

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MitoBloCK-10 Chemical Structure

MitoBloCK-10 Chemical Structure

CAS No. : 394694-98-5

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Description

MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].

In Vitro

MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].
MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].
MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1].

Cell Viability Assay[1]

Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.
Concentration: 100 μM.
Incubation Time: 30 min.
Result: WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.

Cell Viability Assay[1]

Cell Line: HeLa cells.
Concentration: 0-100 μM.
Incubation Time: 24 h.
Result: Inhibited HeLa cells vibility, with an IC50 of 17.2 μM.
Molecular Weight

293.27

Formula

C₁₂H₈FN₃O₃S

CAS No.

394694-98-5

SMILES

O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)C2=CC=CC(F)=C2

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Keywords:

MitoBloCK-10MitoBloCK10MitoBloCK 10OthersMitochondrialProteinImportTim44Inhibitorinhibitorinhibit

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