Tetrahydrodeoxycorticosterone-d3
Based on 1 publication(s) in Google Scholar
Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.
For research use only. We do not sell to patients.
- Purity: 99.53%
- CAS No.: 72205-58-4
- Formula: C21H31D3O3
- Molecular Weight:337.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tetrahydrodeoxycorticosterone-d3
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 72205-58-4
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Unlabeled Cas 567-03-3
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Appearance Solid
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Molecular Weight 337.51
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Formula C21H31D3O3
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([2H])C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
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Synonyms
Tetrahydro-11-deoxycorticosterone-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
2023 Jun 20;4(6):101061. PMID: 37267943
Solvent & Solubility
DMSO : 100 mg/mL (296.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [Content Brief]
[3]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9629 mL | 14.8144 mL | 29.6288 mL | 74.0719 mL |
| 5 mM | 0.5926 mL | 2.9629 mL | 5.9258 mL | 14.8144 mL | |
| 10 mM | 0.2963 mL | 1.4814 mL | 2.9629 mL | 7.4072 mL | |
| 15 mM | 0.1975 mL | 0.9876 mL | 1.9753 mL | 4.9381 mL | |
| 20 mM | 0.1481 mL | 0.7407 mL | 1.4814 mL | 3.7036 mL | |
| 25 mM | 0.1185 mL | 0.5926 mL | 1.1852 mL | 2.9629 mL | |
| 30 mM | 0.0988 mL | 0.4938 mL | 0.9876 mL | 2.4691 mL | |
| 40 mM | 0.0741 mL | 0.3704 mL | 0.7407 mL | 1.8518 mL | |
| 50 mM | 0.0593 mL | 0.2963 mL | 0.5926 mL | 1.4814 mL | |
| 60 mM | 0.0494 mL | 0.2469 mL | 0.4938 mL | 1.2345 mL | |
| 80 mM | 0.0370 mL | 0.1852 mL | 0.3704 mL | 0.9259 mL | |
| 100 mM | 0.0296 mL | 0.1481 mL | 0.2963 mL | 0.7407 mL |
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