1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone (Synonyms: Tetrahydro-11-deoxycorticosterone)

Cat. No.: HY-113346
Handling Instructions

Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.

For research use only. We do not sell to patients.

Tetrahydrodeoxycorticosterone Chemical Structure

Tetrahydrodeoxycorticosterone Chemical Structure

CAS No. : 567-03-3

Size Price Stock
1 mg USD 230 Ask For Quote & Lead Time
5 mg USD 580 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].

In Vitro

The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1].
In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.49

Formula

C₂₁H₃₄O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tetrahydrodeoxycorticosterone
Cat. No.:
HY-113346
Quantity:
MCE Japan Authorized Agent: