Tetrahydrodeoxycorticosterone
Based on 1 Customer Validation
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 567-03-3
- Formula: C21H34O3
- Molecular Weight:334.49
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1].
In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 567-03-3
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Appearance Solid
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Molecular Weight 334.49
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Formula C21H34O3
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Color White to off-white
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SMILES
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2
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Synonyms
Tetrahydro-11-deoxycorticosterone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (298.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [Content Brief]
[2]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9896 mL | 14.9481 mL | 29.8963 mL | 74.7407 mL |
| 5 mM | 0.5979 mL | 2.9896 mL | 5.9793 mL | 14.9481 mL | |
| 10 mM | 0.2990 mL | 1.4948 mL | 2.9896 mL | 7.4741 mL | |
| 15 mM | 0.1993 mL | 0.9965 mL | 1.9931 mL | 4.9827 mL | |
| 20 mM | 0.1495 mL | 0.7474 mL | 1.4948 mL | 3.7370 mL | |
| 25 mM | 0.1196 mL | 0.5979 mL | 1.1959 mL | 2.9896 mL | |
| 30 mM | 0.0997 mL | 0.4983 mL | 0.9965 mL | 2.4914 mL | |
| 40 mM | 0.0747 mL | 0.3737 mL | 0.7474 mL | 1.8685 mL | |
| 50 mM | 0.0598 mL | 0.2990 mL | 0.5979 mL | 1.4948 mL | |
| 60 mM | 0.0498 mL | 0.2491 mL | 0.4983 mL | 1.2457 mL | |
| 80 mM | 0.0374 mL | 0.1869 mL | 0.3737 mL | 0.9343 mL | |
| 100 mM | 0.0299 mL | 0.1495 mL | 0.2990 mL | 0.7474 mL |
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