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Results for "

PH change

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Bacterial (1) Biochemical Assay Reagents (28) Cholecystokinin Receptor (1) COX (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA Stain (1) Drug Isomer (1) Environmental Pollutants (6) Fluorescent Dye (27) Glutathione Peroxidase (1) Influenza Virus (2) Lipoxygenase (1) MMP (3) Parasite (1) Pim (1) Potassium Channel (1) Reference Standards (1)
By Research Areas:	Cancer (9) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0169

Phenol Red 1 Publications Verification PHenolsulfonePHthalein	Environmental Pollutants Fluorescent Dye	Others
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

HY-D0227F

THAM hydrochloride (≥99%, reagent grade) 2 Publications Verification Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)	Biochemical Assay Reagents	Others
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.

HY-15558

Hoechst 33258 Maximum Cited Publications 22 Publications Verification bisBenzimide H 33258; H 33258	Fluorescent Dye DNA Stain DNA Alkylator/Crosslinker	Others
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .

HY-D1224

Chlorophenol red-β-D-galactopyranoside 2 Publications Verification CPRG	Biochemical Assay Reagents	Others
Chlorophenol red-β-D-galactopyranoside (CPRG) is an efficient and sensitive chromogenic substrate for β-galactosidase (HY-P2869), widely used in colorimetric assays. Chlorophenol red-β-D-galactopyranoside itself appears pale yellow. When it is specifically hydrolyzed by β-galactosidase, it releases chlorophenol red. The released chlorophenol red turns purple-red under alkaline or neutral pH conditions. This color change from yellow to red can be quantitatively detected at wavelengths of 540-572 nm using visible spectrophotometry .

HY-A0104D

HPMC (Type I,Viscosity:4000mPa.s) Hypromellose (Type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:4000mPa.s); Celacol HPM 5000 (Type I,Viscosity:4000mPa.s)	Environmental Pollutants Biochemical Assay Reagents	Others
HPMC (Hypromellose) (Type I, Viscosity: 4000mPa.s) is a primary sodium alginate and controlled release hydrophilic polymer with an average viscosity of 4000mPa.s. The viscosity of HPMC may change due to concentration, pH, temperature or the presence of metal ions. When the pH is above 10, the viscosity decreases .

HY-W110798

Bromophenol blue indicator (3.0-4.6) 1 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Others
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.

HY-118907

Methyl Orange	Fluorescent Dye	Others
Methyl Orange is a soluble azo dye commonly used as an acid-base indicator and for staining cells and tissue sections, as well as for dyeing textiles. Methyl Orange appears red at a pH of 3.1 and changes to bright yellow as the pH increases to 4.4. Methyl Orange (500 mg/L) exhibits cytotoxicity and can cause DNA damage .

HY-D0219

Thymol blue ThymolsulPHonePHthalein	Fluorescent Dye	Others
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-Y0699

Methyl red	Environmental Pollutants Fluorescent Dye	Others
Methyl red is a pH-sensitive acid-base indicator and colorimetric reagent with a pKa of 5.1. Methyl red achieves visual judgment of the titration endpoint through reversible structural changes of protonation (red, pH <4.4) and deprotonation (yellow, pH >6.2). Methyl red is widely used in acid-base titration in chemical analysis and buffer pH monitoring in biochemistry .

HY-D0169A

Phenol Red sodium salt 1 Publications Verification PHenolsulfonePHthalein sodium salt	Fluorescent Dye Glutathione Peroxidase	Others
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-W110794

Crystal violet, IND (0.0-2.0)	Environmental Pollutants Biochemical Assay Reagents	Others
Crystal violet, IND (0.0-2.0) is a specialized indicator suitable for strongly acidic systems, which reflects changes in pH within the range of 0.0-2.0 through color changes. Crystal violet, IND (0.0-2.0) is widely used in acid-base titration, chemical analysis, and industrial testing fields .

HY-118155

9-Amino-6-chloro-2-methoxyacridine 2 Publications Verification ACMA	Fluorescent Dye	Others
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H ⁺/solute antiport system .

HY-105028

Tenidap CP-66248	COX Lipoxygenase Potassium Channel MMP	Inflammation/Immunology
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC₅₀=1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis .

HY-D2119

CQ-Lyso 2 Publications Verification	Fluorescent Dye	Cancer
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes .

HY-W087928

Bromocresol purple	Biochemical Assay Reagents	Others
Bromocresol purple is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple can be used for detecting yeast cells with plasma membrane damage and measuring serum albumin concentrations .

HY-D1422

ER Tracker Yellow BDNCA-346	Fluorescent Dye	Others
ER Tracker Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe. ER Tracker Yellow has high temperature sensitivity (3.9%/°C) and is not affected by pH and Ca ²⁺ interference. ER Tracker Yellow can be used for real-time monitoring of local temperature changes in the ER area. ER Tracker Yellow maintains its function in fixed cells. ER Tracker Yellow is suitable for various cell lines and primary cells, such as HeLa cells, MEF cells, and other cells .

HY-179669I

1.5M Tris-HCl Buffer, pH 8.8	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 8.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669C

1M Tris-HCl Buffer, pH 7.6	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 7.6 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669

1M Tris-HCl Buffer, pH 6.8	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-128369

Acid Yellow 36 Metanil Yellow	Environmental Pollutants Cytochrome P450	Others
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .

HY-78035

Citraconic anhydride Methylmaleic anhydride	Biochemical Assay Reagents	Others
Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3 ⁺ into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes .

HY-W011271

PIPES monosodium 1,4-Piperazinediethanesulfonic acid monosodium	Biochemical Assay Reagents	Others
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed .

HY-D0812

Xylenol blue	Fluorescent Dye Biochemical Assay Reagents	Others
Xylenol Blue is a sulfonephthalein dye. It exhibits observable color changes in response to variations in pH. Xylenol Blue undergoes two distinct color transitions across two specific pH ranges: an acidic range and an alkaline range. In a neutral solution, Xylenol Blue appears yellow (at pH 8); in a strongly acidic medium, its color shifts to red (at pH 2.8); and in an alkaline medium, the yellow hue transitions to blue (at pH 9.6) .

HY-128545

Nitrazine yellow Nitrazine paper; PHenaPHthazine	Biochemical Assay Reagents	Others
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .

HY-D0228

4-(4-Nitrophenylazo)resorcinol Azo Violet; Magneson I	Fluorescent Dye	Others
4-(4-Nitrophenylazo)resorcinol (Azo Violet) is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used .

HY-D1556

18:1 PE CF 1,2-dioleoyl-sn-glycero-3-PHosPHoethanolamine-N-(carboxyfluorescein) ammonium	Fluorescent Dye	Cancer
18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .

HY-Y0308D

Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 Disodium hydrogen PHosPHate, meets analytical specification of PH. Eur. BP USP FCC E339	Biochemical Assay Reagents	Endocrinology
Sodium phosphate dibasic (Disodium hydrogen phosphate), meets analytical specification of Ph. Eur. BP USP FCC E339 is an inorganic dibasic phosphate that functions as an electrolyte supplement, a buffer carrier for injectable drugs, while also exhibiting nephrotoxicity. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 induces extensive nephrotic syndrome-like changes, including systemic symptoms such as persistent proteinuria, lipemia, hypercholesterolemia, and anemia, and causes severe renal pathological alterations such as renal enlargement, glomerular calcification, podocyte injury, and tubulointerstitial lesions. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 has the ability to induce phosphate-induced nephropathy and glomerular calcification, and can be widely used in studies on nephrotic syndrome and related renal pathological mechanisms .

HY-20794

8-Hydroxyjulolidine	Fluorescent Dye	Others
8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .

HY-179669A

1M Tris-HCl Buffer, pH 7.0	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 7.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669E

1M Tris-HCl Buffer, pH 8.0	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 8.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-W923277

Sodium sesquicarbonate hydrate	Biochemical Assay Reagents
Sodium sesquicarbonate hydrate is a kind of buffering agent that can stabilize pH value by neutralizing acidic substances without causing a sharp change in pH value. This property makes it widely used in many fields, especially in maintaining acid-base balance in organisms.

HY-D0219A

Thymol Blue sodium	Fluorescent Dye	Others
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue sodium can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field .

HY-N8502

Urdamycin A	Fluorescent Dye	Cancer
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC₅₀s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .

HY-148124

6-epi Doxycycline	Drug Isomer Parasite Bacterial MMP	Others
6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations .

HY-D1560

FG 488 DHPE	Fluorescent Dye	Others
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .

HY-179669J

1.5M Tris-HCl Buffer, pH 6.8	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values ??indicated on the product are the pH values ??of the Tris-HCl buffer solution at 25°C.

HY-179669H

1M Tris-HCl Buffer, pH 8.8	Biochemical Assay Reagents	Others
1M Tris-HCl Buffer, pH 8.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-W110789

Ethyl Orange sodium, indicator grade	Biochemical Assay Reagents	Others
Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.

HY-D0011

Brom0phenol blue sodium 1 Publications Verification	Biochemical Assay Reagents	Others
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .

HY-W087913

alpha-Naphtholphthalein	Biochemical Assay Reagents	Others
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .

HY-W110790

Bromocresol purple sodium	Biochemical Assay Reagents	Others
Bromocresol purple sodium is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple sodium can be used for detecting yeast cells with plasma membrane damage and measuring serum albumin concentrations .

HY-145391

Triperiden	Influenza Virus	Infection
Triperiden is an inhibitor of influenza virus multiplication. Triperiden targets the haemagglutinin of fowl plague virus (FPV) for antiviral activity and acts by inhibiting the conformational change in the haemagglutinin at acid pH. Triperiden is also anticholinergic anti-parkinsonism agent .

HY-110257

BDY FL-X, SE	Fluorescent Dye	Others
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λ_abs: 504 nm; λ_em:510 nm .

HY-D2379

HMRG	Fluorescent Dye	Endocrinology Cancer
HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy .

HY-D1224A

Chlorophenol red β-D-galactopyranoside sodium CPRG sodium	Biochemical Assay Reagents	Others
Chlorophenol red-β-D-galactopyranoside (CPRG) sodium is an efficient and sensitive chromogenic substrate for β-galactosidase (HY-P2869), widely used in colorimetric assays. Chlorophenol red-β-D-galactopyranoside sodium itself appears pale yellow. When it is specifically hydrolyzed by β-galactosidase, it releases chlorophenol red. The released chlorophenol red turns purple-red under alkaline or neutral pH conditions. This color change from yellow to red can be quantitatively detected at wavelengths of 540-572 nm using visible spectrophotometry .

HY-172403

Poly-L-aspartic acid	Biochemical Assay Reagents	Others
Poly-L-aspartic acid is an acidic polypeptide that functions via pH-dependent conformational changes. Poly-L-aspartic acid is promising for research of pH-responsive structural transitions in biological systems .

HY-155717

NDBM	Autophagy Pim	Cancer
NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation .

HY-114352

BODIPY FL-X	Fluorescent Dye	Others
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λ_ex=504 nm, λ_em=510 nm) .

HY-118907R

Methyl Orange (Standard)	Fluorescent Dye Reference Standards	Others
Methyl Orange (Standard) is the analytical standard of Methyl Orange. This product is intended for research and analytical applications. Methyl Orange is a soluble azo dye commonly used as an acid-base indicator and for staining cells and tissue sections, as well as for dyeing textiles. Methyl Orange appears red at a pH of 3.1 and changes to bright yellow as the pH increases to 4.4. Methyl Orange (500 mg/L) exhibits cytotoxicity and can cause DNA damage .

HY-116182

RO5487624	Influenza Virus	Infection
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus .

Cat. No.	Product Name	Type

HY-D0169

Phenol Red 1 Publications Verification PHenolsulfonePHthalein	Fluorescent Dyes
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

HY-15558

Hoechst 33258

Maximum Cited Publications

22 Publications Verification

bisBenzimide H 33258; H 33258

Fluorescent Dyes

Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .

HY-D1224

Chlorophenol red-β-D-galactopyranoside

2 Publications Verification

CPRG

Fluorescent Dyes

Chlorophenol red-β-D-galactopyranoside (CPRG) is an efficient and sensitive chromogenic substrate for β-galactosidase (HY-P2869), widely used in colorimetric assays. Chlorophenol red-β-D-galactopyranoside itself appears pale yellow. When it is specifically hydrolyzed by β-galactosidase, it releases chlorophenol red. The released chlorophenol red turns purple-red under alkaline or neutral pH conditions. This color change from yellow to red can be quantitatively detected at wavelengths of 540-572 nm using visible spectrophotometry .

HY-D0219

Thymol blue

ThymolsulPHonePHthalein

Fluorescent Dyes

Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-D0169A

Phenol Red sodium salt 1 Publications Verification PHenolsulfonePHthalein sodium salt	Fluorescent Dyes
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-118155

9-Amino-6-chloro-2-methoxyacridine 2 Publications Verification ACMA	Fluorescent Dyes
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H ⁺/solute antiport system .

HY-D2119

CQ-Lyso 2 Publications Verification	Fluorescent Dyes
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes .

HY-D1422

ER Tracker Yellow

BDNCA-346

Fluorescent Dyes

ER Tracker Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe. ER Tracker Yellow has high temperature sensitivity (3.9%/°C) and is not affected by pH and Ca ²⁺ interference. ER Tracker Yellow can be used for real-time monitoring of local temperature changes in the ER area. ER Tracker Yellow maintains its function in fixed cells. ER Tracker Yellow is suitable for various cell lines and primary cells, such as HeLa cells, MEF cells, and other cells .

HY-128369

Acid Yellow 36 Metanil Yellow	Fluorescent Dyes
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .

HY-D0812

Xylenol blue

Fluorescent Dyes

Xylenol Blue is a sulfonephthalein dye. It exhibits observable color changes in response to variations in pH. Xylenol Blue undergoes two distinct color transitions across two specific pH ranges: an acidic range and an alkaline range. In a neutral solution, Xylenol Blue appears yellow (at pH 8); in a strongly acidic medium, its color shifts to red (at pH 2.8); and in an alkaline medium, the yellow hue transitions to blue (at pH 9.6) .

HY-D0228

4-(4-Nitrophenylazo)resorcinol

Azo Violet; Magneson I

Fluorescent Dyes

4-(4-Nitrophenylazo)resorcinol (Azo Violet) is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used .

HY-D1556

18:1 PE CF

1,2-dioleoyl-sn-glycero-3-PHosPHoethanolamine-N-(carboxyfluorescein) ammonium

Fluorescent Dyes

18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .

HY-D0219A

Thymol Blue sodium

Fluorescent Dyes

Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue sodium can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field .

HY-D1560

FG 488 DHPE	Fluorescent Dyes
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .

HY-D0011

Brom0phenol blue sodium 1 Publications Verification	Fluorescent Dyes
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .

HY-110257

BDY FL-X, SE	Fluorescent Dyes
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λ_abs: 504 nm; λ_em:510 nm .

HY-D2379

HMRG

Fluorescent Dyes

HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy .

HY-114352

BODIPY FL-X	Fluorescent Dyes
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λ_ex=504 nm, λ_em=510 nm) .

HY-D3005

NpCy-4	Fluorescent Dyes
NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast .

HY-D2992

KSA02

Fluorescent Dyes

KSA02 is a two-dimensional intelligent fluorescent probe. KSA02 not only detects the activity of the aging-related β-galactosidase (SA-β-gal), but also can simultaneously sense the pH value changes of the lysosomal microenvironment where SA-β-gal is located. KSA02 can distinguish between aging and cancer, track the aging process, and evaluate the efficacy of anti-aging agents. KSA02 can be used for the study of aging biology .

HY-D2998

ONOO-LysopH

Fluorescent Dyes

ONOO-LysopH is a new Rhodamine-based near-infrared fluorescent probe. ONOO-LysopH is acid-sensitive, exhibiting rapid near-infrared fluorescence enhancement around 686 nm under acidic pH conditions. ONOO-LysopH also displays a rapid NIR turn-on fluorescence around 678 nm for ONOO− at physiological pH. ONOO-LysopH can target lysosomes to track lysosomal pH changes and image endogenous/exogenous ONOO− in live cells. ONOO-LysopH is applicable for cell imaging ONOO− and tracking lysosomal pH changes .

HY-D3166

CEMT

Fluorescent Dyes

CEMT is a carboxylesterase (CE) substrate and a ratiometric two-photon fluorescent reporter probe. CEMT can be hydrolyzed by CE to generate HMT, which is used for mitochondrial pH sensing. After activation by CE, CEMT exhibits ratiometric fluorescence changes in response to pH variations. CEMT targets and covalently binds to mitochondria, and can avoid leakage during acidification, thus enabling in situ imaging .

HY-D3036

5-(6)-Carboxy SNAFL-1 SE	Fluorescent Dyes
5-(6)-Carboxy SNAFL-1 SE is an amine-reactive succinimidyl ester pH indicator. 5-(6)-Carboxy SNAFL-1 SE can be readily conjugated to peptides, antibodies and other amino-containing molecules such as amino-modified oligos. 5-(6)-Carboxy SNAFL-1 SE can be used for measurement of pH changes between 7-8 (Ex/Em = 490/513 nm) .

HY-D3283

Ctrl-CCF1	Fluorescent Dyes
Ctrl-CCF1 is a control probe for CCF1. Ctrl-CCF1 can be used to distinguish copper-dependent responses from potential dye-dependent variations, such as cellular uptake, retention, subcellular accumulation, and changes in pH, redox or hydrophobic/hydrophilic environments .

Cat. No.	Product Name	Type

HY-D0227F

THAM hydrochloride (≥99%, reagent grade)

2 Publications Verification

Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)

Biochemical Assay Reagents

THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.

HY-A0104D

HPMC (Type I,Viscosity:4000mPa.s) Hypromellose (Type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:4000mPa.s); Celacol HPM 5000 (Type I,Viscosity:4000mPa.s)	Biochemical Assay Reagents
HPMC (Hypromellose) (Type I, Viscosity: 4000mPa.s) is a primary sodium alginate and controlled release hydrophilic polymer with an average viscosity of 4000mPa.s. The viscosity of HPMC may change due to concentration, pH, temperature or the presence of metal ions. When the pH is above 10, the viscosity decreases .

HY-W110798

Bromophenol blue indicator (3.0-4.6)

1 Publications Verification

Biochemical Assay Reagents

Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.

HY-Y0699

Methyl red	Biochemical Assay Reagents
Methyl red is a pH-sensitive acid-base indicator and colorimetric reagent with a pKa of 5.1. Methyl red achieves visual judgment of the titration endpoint through reversible structural changes of protonation (red, pH <4.4) and deprotonation (yellow, pH >6.2). Methyl red is widely used in acid-base titration in chemical analysis and buffer pH monitoring in biochemistry .

HY-W110794

Crystal violet, IND (0.0-2.0)	Biochemical Assay Reagents
Crystal violet, IND (0.0-2.0) is a specialized indicator suitable for strongly acidic systems, which reflects changes in pH within the range of 0.0-2.0 through color changes. Crystal violet, IND (0.0-2.0) is widely used in acid-base titration, chemical analysis, and industrial testing fields .

HY-W087928

Bromocresol purple	Biochemical Assay Reagents
Bromocresol purple is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple can be used for detecting yeast cells with plasma membrane damage and measuring serum albumin concentrations .

HY-179669I

1.5M Tris-HCl Buffer, pH 8.8

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 8.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669C

1M Tris-HCl Buffer, pH 7.6

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 7.6 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669

1M Tris-HCl Buffer, pH 6.8

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-78035

Citraconic anhydride

Methylmaleic anhydride

Biochemical Assay Reagents

Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3 ⁺ into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes .

HY-W011271

PIPES monosodium 1,4-Piperazinediethanesulfonic acid monosodium	Biochemical Assay Reagents
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed .

HY-128545

Nitrazine yellow Nitrazine paper; PHenaPHthazine	Biochemical Assay Reagents
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .

HY-Y0308D

Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339

Disodium hydrogen PHosPHate, meets analytical specification of PH. Eur. BP USP FCC E339

Biochemical Assay Reagents

Sodium phosphate dibasic (Disodium hydrogen phosphate), meets analytical specification of Ph. Eur. BP USP FCC E339 is an inorganic dibasic phosphate that functions as an electrolyte supplement, a buffer carrier for injectable drugs, while also exhibiting nephrotoxicity. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 induces extensive nephrotic syndrome-like changes, including systemic symptoms such as persistent proteinuria, lipemia, hypercholesterolemia, and anemia, and causes severe renal pathological alterations such as renal enlargement, glomerular calcification, podocyte injury, and tubulointerstitial lesions. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 has the ability to induce phosphate-induced nephropathy and glomerular calcification, and can be widely used in studies on nephrotic syndrome and related renal pathological mechanisms .

HY-179669A

1M Tris-HCl Buffer, pH 7.0

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 7.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669E

1M Tris-HCl Buffer, pH 8.0

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 8.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-W923277

Sodium sesquicarbonate hydrate	Biochemical Assay Reagents
Sodium sesquicarbonate hydrate is a kind of buffering agent that can stabilize pH value by neutralizing acidic substances without causing a sharp change in pH value. This property makes it widely used in many fields, especially in maintaining acid-base balance in organisms.

HY-179669J

1.5M Tris-HCl Buffer, pH 6.8

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values ??indicated on the product are the pH values ??of the Tris-HCl buffer solution at 25°C.

HY-179669H

1M Tris-HCl Buffer, pH 8.8

Biochemical Assay Reagents

HY-W110789

Ethyl Orange sodium, indicator grade	Biochemical Assay Reagents
Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.

HY-D0011

Brom0phenol blue sodium 1 Publications Verification	Biochemical Assay Reagents
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .

HY-W087913

alpha-Naphtholphthalein	Biochemical Assay Reagents
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .

HY-W110790

Bromocresol purple sodium	Biochemical Assay Reagents
Bromocresol purple sodium is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple sodium can be used for detecting yeast cells with plasma membrane damage and measuring serum albumin concentrations .

HY-D1224A

Chlorophenol red β-D-galactopyranoside sodium

CPRG sodium

Biochemical Assay Reagents

Chlorophenol red-β-D-galactopyranoside (CPRG) sodium is an efficient and sensitive chromogenic substrate for β-galactosidase (HY-P2869), widely used in colorimetric assays. Chlorophenol red-β-D-galactopyranoside sodium itself appears pale yellow. When it is specifically hydrolyzed by β-galactosidase, it releases chlorophenol red. The released chlorophenol red turns purple-red under alkaline or neutral pH conditions. This color change from yellow to red can be quantitatively detected at wavelengths of 540-572 nm using visible spectrophotometry .

HY-179669D

1M Tris-HCl Buffer, pH 7.8

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 7.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669B

1M Tris-HCl Buffer, pH 7.2

Biochemical Assay Reagents

1M Tris-HCl Buffer, pH 7.2 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

HY-179669K

0.5M Tris-HCl Buffer, pH 8.0

Biochemical Assay Reagents

0.5M Tris-HCl Buffer, pH 8.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.

Cat. No.	Product Name	Target	Research Area

HY-P4116

pH-Low Insertion Peptide PHLIP	Peptides	Metabolic Disease Cancer
pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors .

HY-P4116A

pH-Low Insertion Peptide TFA PHLIP TFA	Peptides	Metabolic Disease Cancer
pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8502

Urdamycin A	Microorganisms Antibiotics Source Classification	Fluorescent Dye
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC₅₀s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .

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