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Results for "

PI3Kα/mTOR-IN-1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10681
    Gedatolisib
    5 Publications Verification

    PKI-587; PF-05212384

    		 PI3K mTOR Cancer
    Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively [1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
    Gedatolisib
  • HY-19962
    Paxalisib
    5 Publications Verification

    GDC-0084

    		 PI3K mTOR Cancer
    Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .
    Paxalisib
  • HY-10681R
    Gedatolisib (Standard)

    		PI3K mTOR Reference Standards Cancer
    Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively [1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
    Gedatolisib (Standard)
  • HY-U00326
    PI3Kα/mTOR-IN-1

    		PI3K mTOR Cancer
    PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.
    PI3Kα/mTOR-IN-1
  • HY-10681S1
    Gedatolisib-d6

    PKI-587-d6; PF-05212384-d6

    		 Isotope-Labeled Compounds PI3K mTOR Cancer
    Gedatolisib-d6 (PKI-587-d6) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively [1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
    Gedatolisib-d6
  • HY-10681S
    Gedatolisib-d8

    PKI-587-d8; PF-05212384-d8

    		 Isotope-Labeled Compounds PI3K mTOR Cancer
    Gedatolisib-d8 (PKI-587-d8) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 [1] .
    Gedatolisib-d8

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