Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
PI3Kα/mTOR-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "PI3Kα/mTOR-IN-1" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: PKI-587; PF-05212384
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively [1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
5
Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .
Cat. No.: HY-10681R
CAS No.: 1197160-78-3
Target:
Research Areas:
Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively [1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
Cat. No.: HY-10681S
Synonyms: PKI-587-d8; PF-05212384-d8
Cat. No.: HY-10681S1
Synonyms: PKI-587-d6; PF-05212384-d6
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
