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Isoforms Recommended: PI3Kδ
Results for "

PI3K-δ

" in MedChemExpress (MCE) Product Catalog:

188

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

6

Natural
Products

5

Isotope-Labeled Compounds

2

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18085
    Quercetin
    195+ Cited Publications

    Reactive Oxygen Species (ROS) PI3K Autophagy Mitophagy Apoptosis Cancer
    Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin
  • HY-18085A
    Quercetin hydrate
    195+ Cited Publications

    PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species (ROS) Cancer
    Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin hydrate
  • HY-102031
    Linperlisib
    1 Publications Verification

    YY-20394

    PI3K Inflammation/Immunology Cancer
    Linperlisib (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM .
    Linperlisib
  • HY-19962
    Paxalisib
    5 Publications Verification

    GDC-0084

    PI3K mTOR Cancer
    Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .
    Paxalisib
  • HY-13898
    Taselisib
    20+ Cited Publications

    GDC-0032; RG-7604

    PI3K Cancer
    Taselisib (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
    Taselisib
  • HY-17635
    Leniolisib
    1 Publications Verification

    CDZ173

    PI3K Inflammation/Immunology
    Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.
    Leniolisib
  • HY-N0146
    Quercetin dihydrate
    190+ Cited Publications

    PI3K Apoptosis Inflammation/Immunology Cancer
    Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin dihydrate
  • HY-109068
    Parsaclisib
    2 Publications Verification

    INCB050465; IBI-376

    PI3K Cancer
    Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies [3].
    Parsaclisib
  • HY-12644
    Acalisib
    1 Publications Verification

    GS-9820; CAL-120

    PI3K Cancer
    Acalisib is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.
    Acalisib
  • HY-12948
    AMG319
    1 Publications Verification

    PI3K Cancer
    AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC50 of 18 nM.
    AMG319
  • HY-10111
    TG100-115
    2 Publications Verification

    PI3K Cardiovascular Disease Cancer
    TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively.
    TG100-115
  • HY-50847
    ZSTK474
    15+ Cited Publications

    PI3K Autophagy Cancer
    ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.
    ZSTK474
  • HY-135827
    Roginolisib
    1 Publications Verification

    MSC2360844; IOA-244

    PI3K Inflammation/Immunology Cancer
    Roginolisib (MSC2360844; IOA-244) is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases .
    Roginolisib
  • HY-109198

    ME-401; PWT-143

    PI3K Akt Cancer
    Zandelisib (ME-401) is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma .
    Zandelisib
  • HY-16526
    Pilaralisib
    5 Publications Verification

    XL-147; SAR245408

    PI3K Cancer
    Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ.
    Pilaralisib
  • HY-11080
    PKI-179
    1 Publications Verification

    PI3K mTOR Cancer
    PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .
    PKI-179
  • HY-10110
    IC-87114
    3 Publications Verification

    PI3K Cancer
    IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM.
    IC-87114
  • HY-19535A

    GSK2269557 free base

    PI3K Cancer
    Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.
    Nemiralisib
  • HY-17645
    Tenalisib
    1 Publications Verification

    RP6530

    PI3K Cancer
    Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.
    Tenalisib
  • HY-16754
    Seletalisib
    2 Publications Verification

    UCB5857

    PI3K Inflammation/Immunology
    Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.
    Seletalisib
  • HY-12869
    AZD-8835
    1 Publications Verification

    PI3K Cancer
    AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively.
    AZD-8835
  • HY-13333

    BAG 956

    PI3K Cancer
    NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
    NVP-BAG956
  • HY-19798
    PI4KIIIbeta-IN-9
    5 Publications Verification

    PI4K PI3K Cancer
    PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.
    PI4KIIIbeta-IN-9
  • HY-17635A
    Leniolisib phosphate
    1 Publications Verification

    CDZ173 phosphate

    PI3K Inflammation/Immunology
    Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.
    Leniolisib phosphate
  • HY-12340

    PI3K Cancer
    ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM, respectively.
    ETP-46321
  • HY-13514
    TG 100713
    2 Publications Verification

    PI3K Cancer
    TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively .
    TG 100713
  • HY-115870

    PI3K Inflammation/Immunology
    AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma .
    AZD8154
  • HY-15280

    PI3K Inflammation/Immunology
    GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease .
    GSK2292767
  • HY-112443

    PI3K Metabolic Disease Inflammation/Immunology Cancer
    AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively .
    AZD3458
  • HY-176239

    PROTACs PI3K Akt Apoptosis Autophagy Cancer
    PROTAC PI3Kδ degrader-1 is a Lysine-targeted covalent PI3Kδ PROTAC degrader with a DC50 of 3.98 nM. PROTAC PI3Kδ degrader-1 has a potent antiproliferative activity and selective PI3Kδ inhibition (IC50: 8 nM). PROTAC PI3Kδ degrader-1 also significantly degrades p-AKT, induces cell cycle arrest in G1 phase and prompts cell apoptosis and autophagy. PROTAC PI3Kδ degrader-1 effectively inhibits the tumor growth in SU-DHL-6 xenograft mice model . Pink: PI3Kδ ligand (HY-169983); Blue: VHL ligase ligand (HY-112078); Black: linker (HY-W013381)
    PROTAC PI3Kδ degrader-1
  • HY-101921

    PI3K Inflammation/Immunology
    PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM.
    PI3Kδ-IN-1
  • HY-147419

    PI3K Cancer
    Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .
    Vulolisib
  • HY-150638

    PI3K Apoptosis Cancer
    PI3Kδ/γ-IN-3 (Compound 58) is a potent and orally active PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 16 nM, respectively. PI3Kδ/γ-IN-3 induces tumor cell apoptosis and can be used for B-cell malignancies research .
    PI3Kδ/γ-IN-3
  • HY-W040417

    PI3K Others
    Boc-L-cyclobutylglycine is a Boc-protected L-cyclic amino acid and synthetic intermediate in the preparation of purinyl quinazolinone PI3Kδ inhibitors .
    Boc-L-cyclobutylglycine
  • HY-17635S

    CDZ173-d5

    Isotope-Labeled Compounds PI3K Inflammation/Immunology
    Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.
    Leniolisib-d5
  • HY-11080A
    PKI-179 hydrochloride
    1 Publications Verification

    PI3K mTOR Cancer
    PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .
    PKI-179 hydrochloride
  • HY-15288

    PI3K Cancer
    PI3kδ inhibitor 1 is a potent and selective PI3Kδ inhibitor with an IC50 of 3.8 nM.
    PI3kδ inhibitor 1
  • HY-16122

    PI3K Cancer
    CAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor.
    CAL-130 Racemate
  • HY-16122A

    PI3K Cancer
    CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.
    CAL-130
  • HY-112439

    PI3K Inflammation/Immunology Cancer
    PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM .
    PI3Kdelta inhibitor 1
  • HY-122593

    PI3K Cancer
    PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC50 of 0.9 nM .
    PI3Kδ-IN-5
  • HY-40029

    (S)-(+)-3-Amino-1-boc-PIperidine

    Biochemical Assay Reagents Drug Intermediate Checkpoint Kinase (Chk) PI3K Others
    (S)-1-Boc-3-aminopiperidine is a key intermediate for the synthesis of various novel inhibitors, such as CHK1 inhibitors and PI3Kδ inhibitors .
    (S)-1-Boc-3-aminopiperidine
  • HY-109029

    INCB040093

    PI3K Cancer
    Dezapelisib (NCB040093) is a potent inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ). Dezapelisib is a promising research strategy for select R/R B-cell lymphomas .
    Dezapelisib
  • HY-12338

    PI3K Bcr-Abl Cancer
    ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
    ON 146040
  • HY-125376

    PI3K Cancer
    PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties .
    PI3Kδ-IN-3
  • HY-109068A
    Parsaclisib hydrochloride
    2 Publications Verification

    INCB050465 hydrochloride; IBI-376 hydrochloride

    PI3K Cancer
    Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies [3].
    Parsaclisib hydrochloride
  • HY-174396

    PI3K HDAC Bcl-2 Family Caspase Reactive Oxygen Species (ROS) Apoptosis Histone Methyltransferase Microtubule/Tubulin Cancer
    PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kδ and HDAC6 with IC50 values of 2.4 nM and 6.2 nM, respectively. PI3Kδ/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kδ/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kδ/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of α-tubulin and histone H3 .
    PI3Kδ/HDAC6-IN-1
  • HY-175369

    PI3K Akt PD-1/PD-L1 Interleukin Related CD3 Inflammation/Immunology Cancer
    PI3Kδ-IN-25 is an orally active selective PI3Kδ inhibitor (IC50 = 2.1 nM). PI3Kδ-IN-25 has IC50s of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. PI3Kδ-IN-25 inhibits AKT Ser473 phosphorylation, suppresses Treg cell proliferation, and downregulates PD-L1 expression in B16F10 cells. PI3Kδ-IN-25 exhibits anticancer effects in B16F10 melanoma and Lewis lung cancer mouse models by reducing tumor-infiltrating Treg cells and enhancing immune responses. PI3Kδ-IN-25 is potentially useful in the study of melanoma, lung cancer, and other cancers .
    PI3Kδ-IN-25
  • HY-147898

    PI3K Apoptosis Cancer
    PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research .
    PI3K-IN-33
  • HY-147900

    PI3K Apoptosis Cancer
    PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research .
    PI3K-IN-35

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