Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
PROTAC SMARCA2 degrader-28
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "PROTAC SMARCA2 degrader-28" in MCE Product Catalog:
Cat. No.: HY-168236
CAS No.: 2641510-88-3
Target:
Research Areas:
PROTAC SMARCA2 degrader-28 (Compound 158) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 with a DC50 of 3 nM in HiBiT A549 cells .
Cat. No.: HY-162835
CAS No.: 2409844-88-6
Target:
Research Areas:
PROTAC SMARCA2/4 degrader-28 is a heterobifunctional PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-28 forms a ternary complex with CRL2VHL E3 ligase and SMARCA2 or SMARCA4, mediating the ubiquitination and degradation of SMARCA2, while acting as a partial degrader of SMARCA4. PROTAC SMARCA2/4-degrader-28 can be used in cancer-related research .
Cat. No.: HY-162834
CAS No.: 2375564-54-6
Target:
Research Areas:
PROTAC SMARCA2/4 degrader-27 is a VHL-recruiting PROTAC degrader targeting SMARCA2 and SMARCA4, derived from structure-guided modification of PROTAC SMARCA2/4 degrader-28 (HY-162835). PROTAC SMARCA2/4-degrader-27 forms a cooperative ternary complex with CRL2VHL E3 ligase to induce ubiquitination and degradation. PROTAC SMARCA2/4-degrader-27 induces a novel protein-protein interaction between VHL and SMARCA2/SMARCA4, thereby stabilizing ternary complex formation and promoting proteasomal degradation of target proteins. PROTAC SMARCA2/4-degrader-27 exhibits enhanced cell permeability and stronger ternary complex formation ability, leading to improved degradation activity. PROTAC SMARCA2/4-degrader-27 can be used in cancer-related research[1].
Cat. No.: HY-168237
CAS No.: 3024271-84-6
Research Areas:
SMARCA2 ligand-10 is a ligand for a target protein, used for the synthesis of PROTAC SMARCA2 degrader-28(HY-168236) .
Cat. No.: HY-168238
Target:
Research Areas:
(4-(3-Bromobenzyl)piperazin-1-yl)(piperidin-4-yl)methanone is a PROTAC linker, used for the synthesis of PROTAC SMARCA2 degrader-28(HY-168236) .
Cat. No.: HY-159680
CAS No.: 2376332-47-5
Target:
Research Areas:
OMs-PEG2-NHAlloc-PEG2-Boc is a PROTAC linker. OMs-PEG2-NHAlloc-PEG2-Boc can be used in synthesis PROTAC SMARCA2/4-degrader-28 (HY-162835) .
Cat. No.: HY-159679
CAS No.: 2409844-90-0
Research Areas:
E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835) .
Cat. No.: HY-168239
Research Areas:
Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates). Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph can be used for the synthesis of PROTAC SMARCA2 degrader-28 (HY-168236) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
