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Results for "

Parasite Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Parasite (157) Acetyl-CoA synthetase (1) Akt (3) Aminoacyl-tRNA Synthetase (1) AMPK (2) Antibiotic (21) Antifolate (3) Apoptosis (14) Autophagy (8) Bacterial (22) Bcl-2 Family (4) CaMK (2) Caspase (4) Cathepsin (3) Cytochrome P450 (5) Dengue Virus (2) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (7) DNA Methyltransferase (3) DNA/RNA Synthesis (1) Drug Metabolite (1) EGFR (2) Elastase (1) Endogenous Metabolite (2) Environmental Pollutants (2) Flavivirus (2) Fungal (10) Glucosylceramide Synthase (GCS) (1) GLUT (1) GSK-3 (1) HBV (1) HCV (1) HDAC (3) Herbicide (1) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (1) HIV (1) HSP (1) HSV (1) Influenza Virus (1) Isotope-Labeled Compounds (6) Microtubule/Tubulin (4) Mitochondrial Metabolism (2) Mitophagy (1) MOFs (1) mTOR (2) N-myristoyltransferase (1) Na+/K+ ATPase (2) nAChR (1) NF-κB (2) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) Paraptosis (2) PARP (4) PDGFR (1) Phosphatase (10) Phosphodiesterase (PDE) (3) PI3K (1) PI4K (2) PKA (3) PKC (2) Proteasome (4) PTEN (2) Pyroptosis (2) RAD51 (2) Reactive Oxygen Species (ROS) (7) Reference Standards (11) SARS-CoV (1) Ser/Thr Kinase (1) Succinate Dehydrogenase (1) Topoisomerase (1) Transmembrane Glycoprotein (1) TrxR (1) VEGFR (2)
By Research Areas:	Cancer (34) Cardiovascular Disease (3) Endocrinology (1) Infection (159) Inflammation/Immunology (13) Metabolic Disease (6) Neurological Disease (1)

By Targets:

Parasite (157)

Acetyl-CoA synthetase (1)

Akt (3)

Aminoacyl-tRNA Synthetase (1)

AMPK (2)

Antibiotic (21)

Antifolate (3)

Apoptosis (14)

Autophagy (8)

Bacterial (22)

Bcl-2 Family (4)

CaMK (2)

Caspase (4)

Cathepsin (3)

Cytochrome P450 (5)

Dengue Virus (2)

Dihydrofolate reductase (DHFR) (2)

Dihydroorotate Dehydrogenase (7)

DNA Methyltransferase (3)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

EGFR (2)

Elastase (1)

Endogenous Metabolite (2)

Environmental Pollutants (2)

Flavivirus (2)

Fungal (10)

Glucosylceramide Synthase (GCS) (1)

GLUT (1)

GSK-3 (1)

HBV (1)

HCV (1)

HDAC (3)

Herbicide (1)

Hexokinase (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Methyltransferase (1)

HIV (1)

HSP (1)

HSV (1)

Influenza Virus (1)

Isotope-Labeled Compounds (6)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (2)

Mitophagy (1)

MOFs (1)

mTOR (2)

N-myristoyltransferase (1)

Na+/K+ ATPase (2)

nAChR (1)

NF-κB (2)

Nucleoside Antimetabolite/Analog (1)

p38 MAPK (2)

Paraptosis (2)

PARP (4)

PDGFR (1)

Phosphatase (10)

Phosphodiesterase (PDE) (3)

PI3K (1)

PI4K (2)

PKA (3)

PKC (2)

Proteasome (4)

PTEN (2)

Pyroptosis (2)

RAD51 (2)

Reactive Oxygen Species (ROS) (7)

Reference Standards (11)

SARS-CoV (1)

Ser/Thr Kinase (1)

Succinate Dehydrogenase (1)

Topoisomerase (1)

Transmembrane Glycoprotein (1)

TrxR (1)

VEGFR (2)

By Research Areas:

Cancer (34)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (159)

Inflammation/Immunology (13)

Metabolic Disease (6)

Neurological Disease (1)

169

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Parasite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13832

Atovaquone 4 Publications Verification Atavaquone	Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-18062

Pyrimethamine 10+ Cited Publications Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection Cancer
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-14989

SQ109 4 Publications Verification NSC 722041	Parasite Bacterial Antibiotic	Infection
SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC₅₀ for cell killing of 50±8 nM. SQ109, targets MmpL3, is an antitubercular agent.

HY-B0621

Triclabendazole 5+ Cited Publications CGA89317	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole is an orally active *parasite* inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-B0148

Risedronic acid 2 Publications Verification Risedronate	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to *parasite* proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-N0841

Bruceine A 3 Publications Verification Dihydrobrusatol; NSC310616	Parasite NF-κB p38 MAPK Phosphatase Apoptosis	Infection Cancer
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of *parasites, NF-κB, and PFKFB4* (K_d: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research .

HY-103397

Nanaomycin A 4 Publications Verification	Antibiotic DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A is the first selective DNMT3B inhibitor with an IC₅₀ of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC₈₀ value of 33.1 nM .

HY-100184

DSM265 2 Publications Verification	Dihydroorotate Dehydrogenase Parasite	Infection
DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC₅₀ of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC₅₀ of 4.3 nM .

HY-103353

SID 26681509 5 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite *Plasmodium falciparum* and inhibits *Leishmania major* with IC₅₀s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G .

HY-B0119

Risedronic acid sodium 2 Publications Verification Risedronate sodium	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-12912

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Infection Cancer
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-121241

Dehydroemetine	Parasite	Infection
Dehydroemetine is an orally active antiparasitic agent. Dehydroemetine can inhibit parasites such as Entamoeba histolytica, and it can also be used in the research of parasitic diseases like visceral leishmaniasis .

HY-169790

Phomarin	Dihydrofolate reductase (DHFR) Parasite Fungal	Infection
Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium *parasites* and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections .

HY-128337

AN7973	Parasite	Infection
AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular *parasite* development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS) Parasite	Infection Endocrinology Cancer
DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites .

HY-176707

GSK2181306A	Parasite	Infection
GSK2181306A is a pan-FIKK inhibitor with an EC₅₀ value of 0.16 μM for parasite growth inhibition. GSK2181306A can be used to study Plasmodium infection .

HY-W013111

2′-Deoxy-GDP trisodium dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium	Nucleoside Antimetabolite/Analog Parasite	Infection
2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC₅₀ of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .

HY-137445

Modoflaner	Parasite	Infection
Modoflaner is an isophenylamide insecticide. Modoflaner may act through allosteric regulation of gamma-aminobutyric acid-gated chloride channels .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .

HY-120060

GNF6702	Parasite	Infection
GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .

HY-119046

SNX-0723 2 Publications Verification	HSP Parasite	Infection
SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with K_is of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC₅₀ of 3.3 μM .

HY-129959

Aluminum phthalocyanine chloride AlClPc	Environmental Pollutants Parasite MOFs	Infection
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-117897

CK-2-68 1 Publications Verification	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-12607

ML251	Parasite	Infection
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC₅₀=0.37 μM) and T. cruzi PFK (IC₅₀=0.13 μM). ML251 can be used for the research of parasite .

HY-117684

Cabamiquine 1 Publications Verification DDD107498; DDD-498; M5717	Parasite CaMK	Infection
Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC₅₀ of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC₅₀ of 2 nM for WT-PfeEF2 .

HY-136750

Z-LLY-FMK Calpain Inhibitor IV	Apoptosis Proteasome Parasite	Cancer
Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis .

HY-175741

IID432	Parasite Topoisomerase	Infection
IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC₅₀ of 8  nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research .

HY-113752

MMV019313	Parasite	Infection
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC₅₀ of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .

HY-117684A

Cabamiquine succinate 1 Publications Verification DDD107498 succinate; DDD-498 succinate; M5717 succinate	Parasite CaMK	Infection
Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC₅₀ of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC₅₀ of 2 nM for WT-PfeEF2 .

HY-138075

Obafluorin	Antibiotic Bacterial Parasite	Infection
Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC₅₀ of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe ³⁺-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and *parasites* such as Plasmodium .

HY-170780

DSM1465	Parasite Dihydroorotate Dehydrogenase	Infection
DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC₅₀ value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC₅₀ value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model .

HY-W588212

trans-Permethrin trans-NRDC-143	Parasite	Neurological Disease
trans-Permethrin is a transconfiguration of Permethrin (HY-B0887). Permethrin is an insecticide and neurotoxin .

HY-108387

Morantel citrate	Parasite	Infection
Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-123601

DHQZ 36	Parasite	Infection
DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits *Leishmania amazonensis* infection in macrophages with an EC₅₀ of 13.63 μM. DHQZ 36 has potent anti-parasite activity .

HY-132170

DSM502	Dihydroorotate Dehydrogenase Parasite	Infection
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs .

HY-D0008

Brilliant green	Bacterial Fungal Parasite	Infection
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal *parasites* and fungus. Brilliant green is effective against Gram-positive bacteria .

HY-136307S

Tizoxanide-d4 glucuronide	Isotope-Labeled Compounds Parasite	Infection
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .

HY-151485

Anti-infective agent 5	Parasite	Infection
Anti-infective agent 5 (compound 74) is an orally active inhibitor of *Trypanosoma cruzi* with an IC₅₀ value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .

HY-18062R

Pyrimethamine (Standard) Pirimecidan (Standard); Pirimetamin (Standard); RP 4753 (Standard)	Reference Standards Antifolate Parasite	Infection
Pyrimethamine (Standard) is the analytical standard of Pyrimethamine. This product is intended for research and analytical applications. Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-W104379

Arprinocid	Parasite	Infection
Arprinocid is a purine analog with activity against murine Toxoplasma gondii .

HY-121493

TM2-115	Histone Methyltransferase Parasite	Infection
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .

HY-118621

JCP174	Elastase Parasite	Infection
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii . JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase .

HY-13832R

Atovaquone (Standard) Atavaquone (Standard)	Reference Standards Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Standard) is the analytical standard of Atovaquone. This product is intended for research and analytical applications. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-120924

BRD9185	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection
BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC₅₀ of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model .

HY-132171

DSM705	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound .

HY-163727

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites .

Cat. No.	Product Name	Type

HY-129959

Aluminum phthalocyanine chloride

AlClPc

Fluorescent Dyes

Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Cat. No.	Product Name	Type

HY-D0008

Brilliant green	Biochemical Assay Reagents
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal *parasites* and fungus. Brilliant green is effective against Gram-positive bacteria .

HY-W104379

Arprinocid	Biochemical Assay Reagents
Arprinocid is a purine analog with activity against murine Toxoplasma gondii .

Cat. No.	Product Name	Target	Research Area

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990804

Anti-Mouse NKG2D/CD314 Antibody (HMG2D)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15310

Ivermectin Maximum Cited Publications 48 Publications Verification MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-N0281

Daphnetin 5+ Cited Publications 7,8-Dihydroxycoumarin	Daphne Classification of Application Fields Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N0841

Bruceine A 3 Publications Verification Dihydrobrusatol; NSC310616	Infection Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification	Parasite NF-κB p38 MAPK Phosphatase Apoptosis
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of *parasites, NF-κB, and PFKFB4* (K_d: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research .

HY-N3980

Guaiol 1 Publications Verification Champacol; Guaiac alcohol	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields Source Classification	Autophagy RAD51
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-129476

L-Canaline	Infection other families Classification of Application Fields Amino acids Plants Endogenous metabolite Disease Research Fields Source Classification	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-169790

Phomarin	Plantaginaceae Digitalis purpurea L. Quinones Structural Classification Anthraquinones Plants Source Classification	Dihydrofolate reductase (DHFR) Parasite Fungal
Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium *parasites* and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections .

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Biological Pesticide Research Agricultural Research Source Classification	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N1074

Warangalone Scandenolone	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-N0281R

Daphnetin (Standard) 7,8-Dihydroxycoumarin (Standard)	Structural Classification Daphne Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N12538

trans-Cinnamic anhydride	Natural Products Cinnamomum verum J. Presl Plants Lauraceae Source Classification	Parasite
trans-Cinnamic anhydride is a *Parasite* inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-N10197

Pulixin	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Coumarins Phenols Polyphenols Phenylpropanoids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM .

HY-N8181

1,3-Linolein-2-Olein	Infection Structural Classification Classification of Application Fields Campanulaceae Plants Codonopsis thalictrifoliaWall. Disease Research Fields Lipid Source Classification	Parasite
1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC₅₀=0.079 ug/ml) and inhibits the growth of amastigotes (IC₅₀= 40.03 ug/ml) .

HY-N3980R

Guaiol (Standard) Champacol (Standard); Guaiac alcohol (Standard)	Structural Classification Natural Products Distemonanthus benthamianus Baill. Plants Compositae Source Classification	Reference Standards Autophagy RAD51
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Structural Classification Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Source Classification	Parasite Phosphodiesterase (PDE)
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Product Name	Chemical Structure

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-136307S

Tizoxanide-d4 glucuronide
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-B0621S

Triclabendazole-d3
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-B0223S4

Albendazole-d3-1

Albendazole-d₃-1 (SKF-62979-d₃-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .

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