1073969-18-2
1073969-18-2
Chemical Structure
SNX-0723
- CAS 番号: 1073969-18-2
- Formula:C22H26FN3O3
- Molecular Weight:399.46
IUPAC Name: (S)-2-fluoro-6-((tetrahydrofuran-3-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide
InChIKey: GAGDTKJJVCLACJ-ZDUSSCGKSA-N
SMILES: O=C(N)C1=C(N[C@@H]2COCC2)C=C(N3C=C(C)C4=C3CC(C)(C)CC4=O)C=C1F
Biological Activity: SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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SNX-0723 | 99.12% | SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-111165SNX-7081 -
Similarity Score 0.56
HY-148877AT-533 -
Similarity Score 0.53
HY-10214SNX-2112 -
Similarity Score 0.51
HY-184394JD-13 -
Similarity Score 0.50
HY-10213SNX-5422 -
Similarity Score 0.49
HY-10213ASNX-5422 mesylate -
Similarity Score 0.46
HY-178956KUNB106 -
Similarity Score 0.45
HY-152775RK-701 -
Similarity Score 0.44
HY-161398TGFβRII-IN-3 -
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