country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184394

Copy Link Print Information

JD-13

JD-13 is a HPV-1 inhibitor and anti-proliferative agent against cancer cells. JD-13 downregulates the expression of HSV-1 DNA polymerase-related genes UL30 and UL42, and inhibits viral replication. JD-13 induces apoptosis (apoptosis) in colorectal cancer cells and suppresses their colony formation. JD-13 can be applied to the research of herpes simplex virus infection and related diseases including colorectal cancer, lung cancer, esophageal cancer and breast cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2969172-58-3
화학식: C₂₅H₃₂N₄O₃
분자량:436.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

JD-13 Chemical Structure

CAS No.: 2969172-58-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

JD-13 (0.125-0.5 μM; 72 h) potently inhibits acyclovir-resistant herpes simplex virus type 1 (HSV-1-153) infection in Vero cells, with near-complete inhibition at concentrations of 0.125, 0.25, and 0.5 μM^[1].
JD-13 (0.125-0.5 μM; 24 h) effectively reduces herpes simplex virus type 1 genomic DNA copy numbers in Vero cells, with stronger activity than acyclovir at concentrations of 0.125, 0.25, and 0.5 μM after 24 hours of incubation^[1].
JD-13 (0.5 μM) most potently inhibits herpes simplex virus type 1 protein expression in Vero cells when administered within the first 6 hours of infection^[1].
JD-13 (0.5 μM; 2-6 h) downregulates the expression of herpes simplex virus type 1 DNA polymerase-related genes UL30 and UL42 in Vero cells, with significant inhibition observed at 4 hours for UL42 and 6 hours for both UL30 and UL42^[1].
JD-13 (20-80 nM; 24 h) inhibits the colony formation ability of HCT116 and SW620 human colon cancer cells after a 24-hour treatment followed by 14 days of drug-free culture^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Vero cells
Concentration:

0.5 μM
Incubation Time:

24 h (added at 0 h post-infection); 21 h (added at 3 h post-infection); 18 h (added at 6 h post-infection); 15 h (added at 9 h post-infection); 12 h (added at 12 h post-infection)
Result:

Showed the strongest inhibitory effect on the expression of HSV-1 proteins gB and ICP0 when added within 6 hours post-infection.
Exhibited weakened inhibitory effect when added at 9 or 12 hours post-infection.

Real Time qPCR^[1]

Cell Line:

Vero cells
Concentration:

0.5 μM
Incubation Time:

2 h; 4 h; 6 h
Result:

Had no significant effect on the expression of UL30 and UL42 at 2 hours post-treatment.
Significantly downregulated UL42 expression at 4 hours post-treatment.
Significantly downregulated both UL30 and UL42 expression at 6 hours post-treatment.

Cell Viability Assay^[1]

Cell Line:

HCT116, SW620, A549, Eca109, MDA-MB-231
Concentration:

Variable concentrations
Incubation Time:

48 h
Result:

Inhibited the viability of HCT116, SW620, A549, Eca109, and MDA-MB-231 cells in a concentration-dependent manner.
Had IC₅₀ values of 35.49 nM for HCT116, 24.64 nM for SW620, 36.19 nM for A549, 35.82 nM for Eca109, and 52.14 nM for MDA-MB-231.
Showed significantly lower IC₅₀ values than the reference compound JD-02.

Cell Proliferation Assay^[1]

Cell Line:

HCT116, SW620
Concentration:

20-80 nM
Incubation Time:

24 h (followed by 14 days of drug-free culture)
Result:

Significantly reduced the size and number of cell colonies formed by HCT116 and SW620 cells compared to the control group.

Apoptosis Analysis^[1]

Cell Line:

HCT116, SW620
Concentration:

Low, medium, and high doses
Incubation Time:

48 h
Result:

Induced typical apoptotic characteristics including cell shrinkage, cytoplasmic condensation, highly condensed and marginalized nuclear chromatin, fragmented nuclei, and apoptotic bodies compared to the blank control group.
Increased the number of cells with strong blue fluorescent apoptotic nuclei in a concentration-dependent manner.

Chemical Information

CAS No. 2969172-58-3
분자량 436.55
화학식 C₂₅H₃₂N₄O₃
SMILES

O=C(C1=CC=C(N2N=C(C)C3=C2CC(C)(C)CC3=O)C=C1NC45CCC(CC4)(CC5)O)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liu Kaisheng, et al. Novel multi-effect benzamide compound and its preparation method, use method and application. CN116554105A. 2023-04-26.

[2]. Xiong Y, et al. Mechanical properties of T-joints of offshore floating photovoltaic structure in marine environment[J]. Journal of Constructional Steel Research, 2026, 245: 110509.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기