1361004-87-6
Chemical Structure
CK-2-68
- CAS No.: 1361004-87-6
- Formula:C24H17ClF3NO2
- Molecular Weight:443.85
IUPAC Name: 7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one
InChIKey: GGVLPENGSGQOOU-UHFFFAOYSA-N
SMILES: O=C1C(C)=C(NC2=C1C=CC(Cl)=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
Biological Activity: CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC50 of 40 nM[1].
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CK-2-68 | 98.91% | CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC50 of 40 nM. | ||||||||||||||||||||
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Keywords
