2. Anti-infection
  3. HCV Dengue Virus Influenza Virus
  4. RYL-634

RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases.

For research use only. We do not sell to patients.

RYL-634

RYL-634 Chemical Structure

CAS No. : 2187352-99-2

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Description

RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against human Caco2 cells infected with MERS-CoV measured after 48 hrs by WST1 assay
Cytotoxicity against human Caco2 cells infected with MERS-CoV measured after 48 hrs by WST1 assay
[PMID: 30938999]
HEK-293T CC50
> 1.25 μM
Compound: 1; RYL-634
Cytotoxicity against HEK293T cells infected with HIV pseudotyped virions assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against HEK293T cells infected with HIV pseudotyped virions assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Huh7.5.1 CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Huh7.5.1 CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against human Huh7.5.1 cells infected with ZIKV assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human Huh7.5.1 cells infected with ZIKV assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Huh7.5.1 EC50
> 2.5 nM
Compound: 1; RYL-634
Cytotoxicity against human Huh7.5.1 cells infected with DENV assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human Huh7.5.1 cells infected with DENV assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
MDCK CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against MDCK cells infected with Gaussia tagged Influenza A virus (A/Puerto Rico/8/34(H1N1)) measured after 48 hrs by WST1 assay
Cytotoxicity against MDCK cells infected with Gaussia tagged Influenza A virus (A/Puerto Rico/8/34(H1N1)) measured after 48 hrs by WST1 assay
[PMID: 30938999]
RD CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against human RD cells infected with EV71 assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human RD cells infected with EV71 assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Vero CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against African green monkey Vero cells infected with CHIKV assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against African green monkey Vero cells infected with CHIKV assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Vero CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against African green monkey Vero cells infected with RSV assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against African green monkey Vero cells infected with RSV assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Vero CC50
> 2.5 μM
Compound: 1; RYL-634
Cytotoxicity against African green monkey Vero cells infected with SFTSV measured after 48 hrs by WST1 assay
Cytotoxicity against African green monkey Vero cells infected with SFTSV measured after 48 hrs by WST1 assay
[PMID: 30938999]
Vero EC50
260 nM
Compound: 1; RYL-634
Antiviral activity against CHIKV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 36 hrs post infection
Antiviral activity against CHIKV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 36 hrs post infection
[PMID: 30938999]
Vero EC50
300 nM
Compound: 1; RYL-634
Antiviral activity against SFTSV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 4 days post infection
Antiviral activity against SFTSV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 4 days post infection
[PMID: 30938999]
Vero EC50
60 nM
Compound: 1; RYL-634
Antiviral activity against RSV infected in African green monkey Vero cells assessed as inhibition of viral replication measured after 5 to 7 days by plaque formation assay
Antiviral activity against RSV infected in African green monkey Vero cells assessed as inhibition of viral replication measured after 5 to 7 days by plaque formation assay
[PMID: 30938999]
Molecular Weight

434.48

Formula

C26H24F2N2O2
CAS No.
SMILES

O=C1C(C)=C(C2=CC(F)=C(OC3=CC=C(N(CC)CC)C=C3)C=C2)NC4=CC=CC(F)=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RYL-634 Related Classifications

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RYL-6342187352-99-2RYL634RYL 634HCVDengue VirusInfluenza VirusHepatitis C virusDENVZIKVEV71HIVvirus infectionInhibitorinhibitorinhibit

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