2187352-99-2
Chemical Structure
RYL-634
- CAS No.: 2187352-99-2
- Formula:C26H24F2N2O2
- Molecular Weight:434.48
IUPAC Name: 2-(4-(4-(diethylamino)phenoxy)-3-fluorophenyl)-5-fluoro-3-methylquinolin-4(1H)-one
InChIKey: LKIAZDKZPNFTIJ-UHFFFAOYSA-N
SMILES: O=C1C(C)=C(C2=CC(F)=C(OC3=CC=C(N(CC)CC)C=C3)C=C2)NC4=CC=CC(F)=C41
Biological Activity: RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases[1].
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RYL-634 | RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases. | |||||||||||||||||||||
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