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Photosensitizer8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-180169
    Photosensitizer-8

    		Photosensitizer Drug Derivative Cancer
    Photosensitizer-8 (Compound 4), 2-anthrol derivative, is an alkaline phosphatase (ALP)-activatable photosensitizer. Photosensitizer-8 undergoes a phosphate ester hydrolysis reaction in the presence of ALP, rapidly converting into the active photosensitizer 2-anthrol. Photosensitizer-8 exhibits cytotoxicity against ALP-overexpressing cancer cells (HeLa, A549, HCT116) after light exposure, with IC50 values of 14.3 μM, 21.6 μM and 17.5 μM, respectively, while showing no significant cytotoxicity against normal lung fibroblasts (WI-38) (IC50 ≥ 30 μM). Photosensitizer-8 can be used in photodynamic therapy research for ALP-overexpression-related cancers .
    Photosensitizer-8
  • HY-161981
    Antitumor photosensitizer-8

    		Apoptosis Cancer
    Antitumor agent-187 (compound I3) is a photosensitizer based on 5,15-diaryltetrabenzoporphyrin with a maximum absorption wavelength of ~668 nm and anticancer activity. Antitumor agent-187 can induce apoptosis and can be used in photodynamic therapy (PDP). Antitumor agent-187 selectively accumulates at tumor sites and has real-time fluorescence imaging capabilities .
    Antitumor photosensitizer-8

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