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Isoforms Recommended:	Quinolone

Results for "

Quinolone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Acyltransferase (1) Angiotensin Receptor (2) Antibiotic (57) Apoptosis (3) Bacterial (93) Beta-lactamase (1) Cannabinoid Receptor (1) DNA/RNA Synthesis (16) Drug Derivative (4) Drug Intermediate (5) E1/E2/E3 Enzyme (1) Elastase (1) Endogenous Metabolite (3) Environmental Pollutants (1) ERK (2) Fungal (2) Glutathione Peroxidase (1) Glutathione S-transferase (1) Integrin (1) Interleukin Related (4) Isotope-Labeled Compounds (13) JNK (2) Mitochondrial Metabolism (1) MMP (2) Molecular Glues (1) Monoamine Oxidase (2) NADPH Oxidase (1) NF-κB (4) NO Synthase (2) p38 MAPK (2) Parasite (6) PARP (1) PGE synthase (2) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (21) Sirtuin (1) SOD (1) STAT (2) TAM Receptor (1) TNF Receptor (1) Topoisomerase (23) Tyrosinase (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (2) Endocrinology (2) Infection (97) Inflammation/Immunology (18) Metabolic Disease (5) Neurological Disease (7)

By Targets:

Acetyl-CoA Carboxylase (1)

Acyltransferase (1)

Angiotensin Receptor (2)

Antibiotic (57)

Apoptosis (3)

Bacterial (93)

Beta-lactamase (1)

Cannabinoid Receptor (1)

DNA/RNA Synthesis (16)

Drug Derivative (4)

Drug Intermediate (5)

E1/E2/E3 Enzyme (1)

Elastase (1)

Endogenous Metabolite (3)

Environmental Pollutants (1)

ERK (2)

Fungal (2)

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Glutathione S-transferase (1)

Integrin (1)

Interleukin Related (4)

Isotope-Labeled Compounds (13)

JNK (2)

Mitochondrial Metabolism (1)

MMP (2)

Molecular Glues (1)

Monoamine Oxidase (2)

NADPH Oxidase (1)

NF-κB (4)

NO Synthase (2)

p38 MAPK (2)

Parasite (6)

PARP (1)

PGE synthase (2)

PPAR (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (21)

Sirtuin (1)

SOD (1)

STAT (2)

TAM Receptor (1)

TNF Receptor (1)

Topoisomerase (23)

Tyrosinase (1)

Wnt (2)

β-catenin (2)

By Research Areas:

Cancer (18)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (97)

Inflammation/Immunology (18)

Metabolic Disease (5)

Neurological Disease (7)

136

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

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Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0398

Nalidixic acid 2 Publications Verification	Bacterial Antibiotic Topoisomerase	Infection
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-177080

Emvistegrast GS-1427	Integrin	Inflammation/Immunology
Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease .

HY-B0526

Flumequine 3 Publications Verification R-802	Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

HY-128200

*Pseudomonas quinolone* signal** 2 Publications Verification PQS	Bacterial	Infection Inflammation/Immunology
Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation .

HY-B0398A

Nalidixic acid sodium salt 2 Publications Verification	Bacterial Antibiotic Topoisomerase	Infection
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-N5009

Thermopsine	Bacterial	Infection
Thermopsine is a quinolone-type alkaloid. Thermopsine exhibits low to moderate anti-E. faecalis activity .

HY-14957

Ozenoxacin T-3912	Bacterial Antibiotic	Infection
Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-16487

Temafloxacin TMFX; TA-167 free acid; A-62254 free acid	Bacterial Antibiotic	Infection
Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections .

HY-17460A

Garenoxacin Mesylate hydrate BMS284756 Mesylate hydrate	Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic	Infection
Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .

HY-49444

EN450	NF-κB Molecular Glues E1/E2/E3 Enzyme	Cancer
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism .

HY-W011117

Danofloxacin	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens .

HY-129503

2-Heptyl-4-quinolone	Drug Intermediate	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-N2060

Evocarpine	Apoptosis Bacterial	Infection Inflammation/Immunology Cancer
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-106410A

Zabofloxacin hydrochloride DW-224a	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-17460

Garenoxacin BMS284756	Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic	Infection
Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .

HY-120338

RYL-552	Mitochondrial Metabolism Parasite	Infection
RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a *P. falciparum NADH dehydrogenase 2 (PfNDH2)* inhibtor .

HY-W004769

Benzo[h]quinoline α-Naphthoquinoline	Environmental Pollutants Drug Intermediate	Others
Benzo[h]quinolone is a widespread environmental pollutant. Benzo[h]quinolone is mutagenic. Benzo(h)quinoline derivatives can serve as G-quadruplex binding agents .

HY-59208

4-Quinolinol Kynurine	Endogenous Metabolite	Neurological Disease Cancer
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-U00221

Amifloxacin Win49375	Bacterial	Infection
Amifloxacin (Win49375) is a synthetic antibacterial agent of the quinolone class.

HY-108279

Ulifloxacin	Antibiotic Bacterial	Infection
Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity .

HY-W004782

3-Methylthiophene-2-carboxylic acid	Bacterial	Inflammation/Immunology
3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a K_d of 19.6 µM and an IC₅₀ of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research .

HY-106410

Zabofloxacin DW-224a Free base	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-W020111

7-Chloro-4-(piperazin-1-yl)quinoline	Sirtuin Parasite	Infection
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC₅₀ of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of *P. falciparum* with IC₅₀s of 1.18 μM and 0.97 μM, respectively .

HY-123271

Ro 23-9424	Bacterial Antibiotic	Infection
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro .

HY-116229

Gemifloxacin SB-265805; LB20304	Antibiotic Bacterial	Infection
Gemifloxacin, a fluoroquinolone, is a potent and orally active antipneumococcal agent. Gemifloxacin shows bactericidal activity against highly quinolone-resistant pneumococci.Gemifloxacin can be used for the research of respiratory infections, such as community-acquired pneumonia (CAP) and acute exacerbation of chronic bronchitis (AECB) .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Acyltransferase Angiotensin Receptor Bacterial	Infection Cardiovascular Disease Metabolic Disease
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-171190

ELQ-316	Parasite	Infection
ELQ-316 is an endochinlike quinolone compound and an anti-parasite agent. ELQ-316 demonstrates a great efficacy against acute and chronic experimental toxoplasmosis .

HY-B0455B

Lomefloxacin (aspartate) SC47111A (aspartate); NY-198 (aspartate)	Bacterial Antibiotic	Infection
Lomefloxacin (SC47111A) aspartate is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin aspartate can be used for researching respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-21509

8-Hydroxycoumarin 1 Publications Verification	NADPH Oxidase	Others
8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone .

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Bacterial	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-113595

Temafloxacin hydrochloride TMFX hydrochloride; TA-167; A-62254	Antibiotic Bacterial	Infection
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections .

HY-109855

CP-67015	Topoisomerase Antibiotic Bacterial	Infection
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects .

HY-B0526S

Flumequine-13C3	Isotope-Labeled Compounds Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa .

HY-N0968

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone	Others	Others
1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, as a colorless oil, is a quinolone alkaloid isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) .

HY-B1036R

Decoquinate (Standard)	Reference Standards Parasite	Infection
Decoquinate (Standard) is the analytical standard of Decoquinate. This product is intended for research and analytical applications. Decoquinate is a quinolone derivative that can be used for research of coccidiosis in domestic ruminants. Decoquinate also has potent activity against both Plasmodium hepatic development and red cell replication .

HY-156332

TNKS-2-IN-2	PARP	Cancer
TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC₅₀ of 22 nM .

HY-129503S1

*2-Heptyl-4-quinolone-15N*	Isotope-Labeled Compounds Drug Intermediate	Others
2-Heptyl-4-quinolone- ¹⁵N is the ¹⁵N-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-124352

2-Nonyl-3-hydroxy-4-quinolone	Bacterial	Others
2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .

HY-123029

5,6,7,8-Tetrahydro-2-quinolone NSC 99006	Drug Intermediate	Others
5,6,7,8-Tetrahydro-2-quinolone (NSC 99006) is a synthetic intermediate useful for pharmaceutical synthesis.

HY-124352S

*2-Nonyl-3-hydroxy-4-quinolone-d4* C9-PQS-d₄	Isotope-Labeled Compounds Bacterial	Others
2-Nonyl-3-hydroxy-4-quinolone-d₄ (C9-PQS-d₄) is deuterium labeled 2-Nonyl-3-hydroxy-4-quinolone. 2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .

HY-D0113

7-Hydroxy-4-methyl-2(1H)-quinolone	Reactive Oxygen Species (ROS)	Others
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .

HY-122260

S-25932	Bacterial	Infection
S-25932 is a potent 4-quinolones antibacterial agent. S-25932 shows broad gram-negative antibacterial activity. S-25932 shows inhibition for Enterobacter aerogenes, Enterobacter addlomerans, Enterobacter coloacae, Escherichia coli with MIC₉₀ values of 1.0, 2.0, 1.0, 0.25 µg/mL, respectively .

HY-17460B

Garenoxacin mesylate BMS 284756 mesylate	Bacterial Topoisomerase Antibiotic	Infection
Garenoxacin (BMS 284756) mesylate is an orally active quinolone antibiotic and Garenoxacin mesylate has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes. Garenoxacin mesylate also inhibits Gyrase and TOPO IV .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-105434

CP-74667	Bacterial	Infection
CP-74667 is a quinolone antibacterial agent. CP-74667 shows high activity against Xanthomonas maltophilia (MIC₅₀ = 1 μg/mL), Staphylococcus spp. (MIC₅₀ = 0.06-0.12 μg/mL) and enterococci (MIC₅₀ = 0.5-4 μg/mL) .

HY-150041

TL4830031	TAM Receptor	Cancer
TL4830031 (compound 8i), a quinolone antibiotic derivatives, is a potent Axl inhibitor with an IC₅₀ value of 26 nM. TL4830031 inhibits the phosphorylation of Axl. TL4830031 inhibits cell invasion and migration. TL4830031 can be used for cancer research .

HY-108021

HT-61	Bacterial	Infection
HT-61 is a quinolone antibacterial agent. HT-61 exhibits bactericidal activity against gram-positive bacteria including methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). HT-61 can enhance the effect of Tobramycin (HY-B0441) against Pseudomonas aeruginosa .

HY-146098

Antibacterial agent 105	Bacterial Antibiotic	Infection
Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC₉₀=2.64 μM). Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC₉₀s of 11.18, 11.18, 0.70, 1.40, 44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes and S. aureus, respectively .

Cat. No.	Product Name

HY-L0107V

Life Chemicals Natural Product-like Compound Library

13,236 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0398

Nalidixic acid 2 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic Topoisomerase
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-N5009

Thermopsine	Infection Alkaloids Structural Classification Classification of Application Fields Leguminosae Pyridine Alkaloids Plants Thermopsis lanceolala R.Br. Disease Research Fields Source Classification	Bacterial
Thermopsine is a quinolone-type alkaloid. Thermopsine exhibits low to moderate anti-E. faecalis activity .

HY-116474

Viridicatol	Infection Alkaloids Structural Classification Monophenols Microorganisms Classification of Application Fields Phenols Quinoline Alkaloids Disease Research Fields Source Classification	ERK JNK MMP p38 MAPK STAT Fungal Bacterial NO Synthase PGE synthase NF-κB Wnt β-catenin
Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

HY-129503

2-Heptyl-4-quinolone	Alkaloids Microorganisms Quinoline Alkaloids Source Classification	Drug Intermediate
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-N2060

Evocarpine	Infection Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bacterial
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-59208

4-Quinolinol Kynurine	Alkaloids Neurological Disease Classification of Application Fields Quinoline Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Source Classification	Acyltransferase Angiotensin Receptor Bacterial
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Source Classification	Monoamine Oxidase
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Angiotensin Receptor
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa .

HY-N0968

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone	Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Other Diseases Quinoline Alkaloids Plants Disease Research Fields Source Classification	Others
1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, as a colorless oil, is a quinolone alkaloid isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) .

HY-124199

Cephalochromin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL .

HY-B0398R

Nalidixic acid (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Topoisomerase
Nalidixic acid (Standard) is the analytical standard of Nalidixic acid. This product is intended for research and analytical applications. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-108953

(S)-Quinolactacine A	Alkaloids Microorganisms Classification of Application Fields Quinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Others
(S)-Quinolactacine A is a quinolone inhibitor that targets TNF production .

HY-N14512

Quinolactacin C	Alkaloids Microorganisms Quinoline Alkaloids Source Classification	Bacterial
Quinolactacin C is a quinolone found in Penicillum sp. EPF-6 .

HY-N14511

Quinolactacin B	Alkaloids Microorganisms Quinoline Alkaloids Source Classification	Bacterial
Quinolactacin B is a quinolone found in Penicillum sp. EPF-6 .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Alkaloids Neurological Disease Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Monoamine Oxidase
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

HY-N1637

1-Methyl-2-pentyl-4(1H)-quinolinone	Infection Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Source Classification	Bacterial
1-Methyl-2-pentyl-4(1H)-quinolinone, a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa, possesses antibacterial and cytotoxic activities for cancer cells .

HY-B1908R

Midecamycin (Standard) SF-837 (Standard); Antibiotic SF-837 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Lomefloxacin (Standard) is the analytical standard of Lomefloxacin. This product is intended for research and analytical applications. Lomefloxacin (SC47111A) is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-N1750R

3-(2,4-Dihydroxyphenyl)propanoic acid (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Ficus carica L. Phenols Polyphenols Plants Moraceae Endogenous metabolite Source Classification	Reference Standards Tyrosinase Endogenous Metabolite
Garenoxacin (Standard) is the analytical standard of Garenoxacin. This product is intended for research and analytical applications. Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .

HY-N10907

4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-	Alkaloids Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley Source Classification	Bacterial
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .

HY-116474R

Viridicatol (Standard)	Alkaloids Structural Classification Monophenols Microorganisms Phenols Quinoline Alkaloids Source Classification	Reference Standards JNK β-catenin NO Synthase PGE synthase Fungal STAT ERK MMP p38 MAPK Bacterial NF-κB Wnt
Viridicatol (Standard) is the analytical standard of Viridicatol (HY-116474). This product is intended for research and analytical applications. Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

HY-402321

2-Octyl-4(1H)-quinolone	Alkaloids Other Alkaloids Ruta graveolens Linn. Rutaceae Plants Source Classification	Others
2-Octyl-4(1H)-quinolone (Compound 14) is a quinolinone alkaloid that can be isolated from Ruta graveolens .

HY-N16462

2-(2-Heptenyl)-3-methyl-4(1H)-quinolone	Natural Products Microorganisms Source Classification	Bacterial
2-(2-Heptenyl)-3-methyl-4(1H)-quinolone is a quinoline alkaloid found in Burkholderia sp. VY81. 2-(2-Heptenyl)-3-methyl-4(1H)-quinolone is promising for research of bacterial diseases in rice (e.g., soft rot) and other plant pathogens (e.g., Pythium ultimum, Fusarium oxysporum) .

HY-105608

Narceine Narcein	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Papaveraceae Corydalis longipes Source Classification	Others
Narceine (Narcein), a quinolone derivative, is an opium alkaloid with anti-diabetic property .

HY-59208R

4-Quinolinol (Standard) Kynurine (Standard)	Structural Classification Alkaloids Quinoline Alkaloids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
4-Quinolinol (Standard) is the analytical standard of 4-Quinolinol. This product is intended for research and analytical applications. 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

Cat. No.	Product Name	Chemical Structure

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-129503S1

*2-Heptyl-4-quinolone-15N*
2-Heptyl-4-quinolone- ¹⁵N is the ¹⁵N-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-124352S

*2-Nonyl-3-hydroxy-4-quinolone-d4*
2-Nonyl-3-hydroxy-4-quinolone-d₄ (C9-PQS-d₄) is deuterium labeled 2-Nonyl-3-hydroxy-4-quinolone. 2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .

HY-W717950

*Pseudomonas quinolone* signal-d4**
Pseudomonas quinolone signal-d4 is a stable isotope internal standard .

HY-B0343BS

Sarafloxacin-d8 hydrochloride trihydrate
Sarafloxacin-d₈ (hydrochloride trihydrate) is the deuterium labeled Sarafloxacin hydrochloride trihydrate. Sarafloxacin hydrochloride trihydrate is a quinolone antibiotic compound .

HY-B0343AS

Sarafloxacin-d8 hydrochloride
Sarafloxacin-d8 (A-56620-d8) hydrochloride is the deuterium labeled Sarafloxacin hydrochloride. Sarafloxacin hydrochloride (A-56620 hydrochloride) is a quinolone antibiotic drug.

HY-W018677S

Quinoxaline-d4
Quinoxaline-d₄ is the deuterium labeled Quinoxaline . Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics .

HY-14957AS

Ozenoxacin-d3 hydrochloride
Ozenoxacin-d₃ (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections .

HY-14957S

Ozenoxacin-d3
Ozenoxacin-d₃ is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d₃ is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-B0455S

Lomefloxacin-d5 hydrochloride
Lomefloxacin-d₅ (hydrochloride) is the deuterium labeled Lomefloxacin hydrochloride. Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-W011117S

Danofloxacin-d3
Danofloxacin-d₃ is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-W011117S1

Danofloxacin-d3-1
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-B1085S

Cinoxacin-d5

Cinoxacin-d₅ is the deuterium-labeled Cinoxacin (HY-B1085) . Cinoxacin (Compound 64716)，a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .

HY-B0506S1

Nadifloxacin-d5

Nadifloxacin-d₅ (OPC7251-d₅) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

HY-129503S

*2-Heptyl-4-quinolone-13C6*
2-Heptyl-4-quinolone- ¹³C₆ is the ¹³C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-108279S

Ulifloxacin-d8
Ulifloxacin-d₈ is the deuterium labeled Ulifloxacin (HY-108279) . Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity.

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