108985-27-9
Chemical Structure
Pseudomonas quinolone signal
Synonym(s): PQS
- CAS No.: 108985-27-9
- Formula:C16H21NO2
- Molecular Weight:259.35
IUPAC Name: 2-heptyl-3-hydroxyquinolin-4(1H)-one
InChIKey: CEIUIHOQDSVZJQ-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(CCCCCCC)NC2=C1C=CC=C2
Biological Activity: Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation[1][2][3][4].
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Pseudomonas quinolone signal | 99.84% | Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation. | ||||||||||||||||||||
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Pseudomonas quinolone signal-d4 | Pseudomonas quinolone signal-d4 is a stable isotope internal standard. | |||||||||||||||||||||
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- [1]. Pesci E C, et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa[J]. Proceedings of the National Academy of Sciences, 1999, 96(20): 11229-11234. [Content Brief]
- [2]. Bredenbruch F, et al. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ Microbiol. 2006 Aug;8(8):1318-29. [Content Brief]
- [3]. Cooke AC, et al. Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa. mSphere. 2020 Nov 25;5(6):e01109-20. [Content Brief]
- [4]. Lin J, et al. The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore. Front Cell Infect Microbiol. 2018 Jul 4;8:230. [Content Brief]
