793719-01-4
793719-01-4
Chemical Structure
EN450
- CAS No.: 793719-01-4
- Formula:C11H13ClN2O3S
- Molecular Weight:288.76
IUPAC Name: N-(2-chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
InChIKey: OXFXDOLAQBMOPH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
Biological Activity: EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EN450 | 98.59% | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.72
HY-111530GSTO1-IN-1 -
Similarity Score 0.62
HY-109586BRL-50481 -
Similarity Score 0.61
HY-116923p18SMI-21 -
Similarity Score 0.60
HY-W040295Fast Red ITR -
Similarity Score 0.60
HY-B1429RChlorpropamide (Standard) -
Similarity Score 0.59
HY-206870BP79 -
Similarity Score 0.59
HY-B0939Etebenecid -
Similarity Score 0.59
HY-155597h-NTPDase8-IN-1 -
Similarity Score 0.58
HY-W029652((2,6-Dichlorophenyl)sulfonyl)glycine -
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