793719-01-4
793719-01-4
Chemical Structure
EN450
- CAS No.: 793719-01-4
- Formula:C11H13ClN2O3S
- Molecular Weight:288.76
IUPAC Name: N-(2-chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
InChIKey: OXFXDOLAQBMOPH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
Biological Activity: EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1].
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EN450 | 98.59% | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism. | ||||||||||||||||||||
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References
Keywords
