4 Results for "

SAMP8 mice

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "SAMP8 mice" in MCE Product Catalog:

1
Notoginsenoside R2
Notoginsenoside R2
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1 Cited Publications
Cat. No.: HY-N0909
CAS No.: 80418-25-3
Synonyms: 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2
Category:  

Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Neurological Disease Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Apoptosis MEK ERK Reactive Oxygen Species (ROS) Caspase COX β-catenin Src MDM-2/p53 JAK STAT

Notoginsenoside R2 (20(S)-Notoginsenoside R2; Ginsenoside Ng-R2) is an orally active notoginsenoside . Notoginsenoside R2 activates P90RSK and Nrf2 via the MEK1/2-ERK1/2 pathway to inhibit 6-OHDA-induced apoptotic damage in nerve cells. Notoginsenoside R2 upregulates SOX8/β-catenin by reducing miR-27a, thereby suppressing Aβ25-35-induced neuronal apoptosis and inflammatory responses . Notoginsenoside R2 alleviates lipid accumulation and mitochondrial dysfunction in diabetic nephropathy by inhibiting c-Src. Notoginsenoside R2 alleviates hepatic fibrosis by inducing hepatic stellate cell senescence and inhibiting the inflammatory microenvironment via JAK/STAT3 suppression . Notoginsenoside R2 can be used in research related to Parkinson's disease, Alzheimer's disease, diabetic nephropathy and hepatic fibrosis .
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Mesaconic acid
Mesaconic acid
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Cat. No.: HY-78036
CAS No.: 498-24-8
Synonyms: Citronic acid; Methylfumaric acid
Category:  

Brassica oleracea L. Ketones, Aldehydes, Acids Other Diseases Plants Brassicaceae Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite NF-κB Keap1-Nrf2 Bcl-2 Family Caspase NOD-like Receptor (NLR) Cathepsin

Mesaconic acid (Citronic acid; Methylfumaric acid) is an orally active anti-inflammatory and antioxidant agent. Mesaconic acid reduces the level of NF-κB in colon tissues, downregulates the expression of Keap1 and Bax, upregulates the expression of Nrf2 and Bcl2, and decreases the expression of Caspase-1. Mesaconic acid reduces the levels of NLRP3, ASC and Casp-1 in colon, liver and kidney tissues. Mesaconic acid reduces pro-inflammatory cytokine levels, increases the level of the anti-inflammatory cytokine IL-10, elevates NAD + levels, regulates oxidative stress markers and antioxidant enzyme levels, and upregulates intestinal barrier proteins in colon, liver and kidney tissues. Mesaconic acid increases the abundance of beneficial gut bacteria and reduces the abundance of harmful gut bacteria in rapidly aging mice, and exhibits anti-aging properties. Mesaconic acid acts as a flame retardant and serves as a competitive inhibitor of fumarate reduction. Mesaconic acid can be used in the research of aging-related inflammation .
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Indeloxazine
Indeloxazine
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Cat. No.: HY-17032
CAS No.: 60929-23-9
Synonyms: (rac)-AS1069562 free base; YM-08054 free base
Target:  

Endogenous Metabolite

Research Areas:  

Neurological Disease

Indeloxazine ((rac)-AS1069562 free base) is a brain active compound with anti-amnesic activity. Indeloxazine significantly prolonged the step latency in senescence accelerated mice (SAM-P/8/Ta), indicating that it has a promoting effect on brain function. Indeloxazine has a broader pharmacology than piracetam and exhibits stronger anti-amnesic activity. Indeloxazine has also been used as an anticonvulsant compound, further supporting its potential use in neuroprotection and behavioral improvement .
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FTO-IN-17
FTO-IN-17
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Cat. No.: HY-183325
CAS No.: 1434867-98-7
Target:  

Fat Mass and Obesity-associated Protein (FTO) CXCR TNF Receptor

Research Areas:  

Neurological Disease

FTO-IN-17 is an orally active and brain-penetrant FTO (m6A RNA demethylase) inhibitor with an IC50 of 1.1 μM. FTO-IN-17 stably binds the FTO catalytic pocket. FTO-IN-17 protects against Aβ1-42-induced toxicity while increasing global m6A levels and dampening pro-inflammatory gene (CXCL10, TNF-α) expression. FTO-IN-17 ameliorates anxiety-like behavior and rescues hippocampal-dependent spatial, recognition memory and neuroinflammation in Alzheimer's disease mice models .
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