1434867-98-7
Chemical Structure
FTO-IN-17
- CAS No.: 1434867-98-7
- Formula:C20H23FN4O2
- Molecular Weight:370.42
InChIKey: IMYMASDLCHCTQI-UHFFFAOYSA-N
SMILES: CC(C1=NOC(C2CCCN(C2)CC3=NC4=C(C=CC=C4C(O)=C3)F)=N1)C
Biological Activity: FTO-IN-17 is an orally active and brain-penetrant FTO (m6A RNA demethylase) inhibitor with an IC50 of 1.1 μM. FTO-IN-17 stably binds the FTO catalytic pocket. FTO-IN-17 protects against Aβ1-42-induced toxicity while increasing global m6A levels and dampening pro-inflammatory gene (CXCL10, TNF-α) expression. FTO-IN-17 ameliorates anxiety-like behavior and rescues hippocampal-dependent spatial, recognition memory and neuroinflammation in Alzheimer's disease mice models[1].
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FTO-IN-17 | FTO-IN-17 is an orally active and brain-penetrant FTO (m6A RNA demethylase) inhibitor with an IC50 of 1.1 μM. FTO-IN-17 stably binds the FTO catalytic pocket. FTO-IN-17 protects against Aβ1-42-induced toxicity while increasing global m6A levels and dampening pro-inflammatory gene (CXCL10, TNF-α) expression. FTO-IN-17 ameliorates anxiety-like behavior and rescues hippocampal-dependent spatial, recognition memory and neuroinflammation in Alzheimer's disease mice models. | |||||||||||||||||||||
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Keywords
