4 Results for "

SCID mouse xenografts

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "SCID mouse xenografts" in MCE Product Catalog:

Cat. No.: HY-P10775A
Target:  

MMP

Research Areas:  

Cancer

BT1769 acetate is a conjugate and antitumor agent targeting MT1-MMP, with a Kd value of 3.35 nM against human targets. BT1769 acetate exhibits favorable pharmacokinetic properties. BT1769 acetate specifically binds to MT1-MMP via its bicyclic peptide component, delivering the cytotoxic agent MMAE (HY-15162) to antigen-expressing cells. It effectively inhibits tumor growth, induces complete responses, and significantly prolongs event-free survival in osteosarcoma patient-derived xenograft models. BT1769 acetate shows extremely low activity in Ewing sarcoma models and can be used in osteosarcoma-related research .
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Cat. No.: HY-184178A
Target:  

Apoptosis

Research Areas:  

Cancer

HF-125 is an orally active, highly selective small-molecule inhibitor of Tribbles 2 (TRIB2). HF-125 promotes the destabilization and degradation of TRIB2 protein via the proteasome pathway. HF-125 downregulates neuroendocrine markers, induces cell cycle arrest and apoptosis, inhibits tumor cell colony formation and invasion, and reverses tumor cell resistance to Enzalutamide (HY-70002). HF-125 significantly inhibits tumor growth in SCID mouse xenograft models, and exerts synergistic inhibitory effects when combined with Enzalutamide. HF-125 can be used in research related to prostate cancer .
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Cat. No.: HY-186268
CAS No.: 3034180-15-6
Research Areas:  

Cancer

BRD4 ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that can be used in studies related to PROTAC synthesis. BRD4 ligand-Linker Conjugate 8 is applicable for the synthesis of BD-7148 (HY-186267) .
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Cat. No.: HY-181986
CAS No.: 2440087-57-8
Target:  

Lipase Apoptosis

Research Areas:  

Cancer

ERX-208 is an anticancer agent that induces endoplasmic reticulum stress by targeting lysosomal acid lipase A (LIPA), ultimately leading to cancer cell apoptosis. ERX-208 can be used in ovarian cancer research .
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