Search Result

Results for "

SGC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (2) Adrenergic Receptor (1) Akt (1) AMPK (1) Apoptosis (15) Autophagy (1) c-Met/HGFR (2) Calcium Channel (1) Calmodulin (1) Carbonic Anhydrase (1) Casein Kinase (2) CDK (2) CHIKV (1) CMV (1) Collagen (1) Cyclin G-associated Kinase (GAK) (1) DAPK (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Elastase (3) Endogenous Metabolite (2) Environmental Pollutants (4) Epigenetic Reader Domain (4) Flavivirus (1) Fluorescent Dye (1) GSK-3 (1) Guanylate Cyclase (52) HDAC (2) Histone Acetyltransferase (1) Histone Methyltransferase (10) HSP (2) Interleukin Related (1) Isotope-Labeled Compounds (3) LDLR (1) Lysyl Oxidase (1) Microtubule/Tubulin (8) MMP (1) Monoamine Oxidase (8) Neurotensin Receptor (1) NF-κB (2) NO Synthase (9) PAK (1) Parasite (1) Phosphodiesterase (PDE) (2) PKG (2) Potassium Channel (1) Reactive Oxygen Species (ROS) (1) Reference Standards (13) Small Interfering RNA (siRNA) (2) STAT (1) TGF-β Receptor (1) Virus Protease (2) Wnt (2) YAP (1)
By Research Areas:	Cancer (61) Cardiovascular Disease (39) Infection (9) Inflammation/Immunology (17) Metabolic Disease (9) Neurological Disease (13)
Oligonucleotides:	Aptamers (3) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

120

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15826

SGC-CBP30 15+ Cited Publications	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (K_ds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .

HY-14779

Riociguat 15+ Cited Publications BAY 632521	Guanylate Cyclase	Cardiovascular Disease
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-14927

Lificiguat Maximum Cited Publications 33 Publications Verification YC-1	Guanylate Cyclase	Cardiovascular Disease Cancer
Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with K_d of 0.6-1.1 μM in the presence of CO.

HY-19715

SGC707 10+ Cited Publications	Histone Methyltransferase	Metabolic Disease
SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC₅₀=31 nM, K_d=53 nM).

HY-112445

SGC3027 5+ Cited Publications	Histone Methyltransferase	Cancer
SGC3027 is a histone methyltransferase inhibitor . SGC3027 is the first potent, selective and cell active chemical probe for PRMT7 .

HY-145446

SGC-SMARCA-BRDVIII	Epigenetic Reader Domain	Metabolic Disease
SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with K_ds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with K_ds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts .

HY-B1359

Methylene blue trihydrate 25+ Cited Publications C.I. Basic Blue 9 trihydrate	Guanylate Cyclase Monoamine Oxidase NO Synthase Parasite	Infection Neurological Disease Cancer
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment .

HY-15650

SGC0946 10+ Cited Publications	Histone Methyltransferase	Cancer
SGC0946 is a selective DOT1L inhibitor with an IC₅₀ value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells .

HY-122186

SGC-GAK-1 2 Publications Verification	Cyclin G-associated Kinase (GAK)	Cancer
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a K_i of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK .

HY-101255

ODQ 10+ Cited Publications	Guanylate Cyclase Apoptosis	Cancer
ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .

HY-139004

SGC-CK2-1 5 Publications Verification	Casein Kinase	Neurological Disease
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC₅₀s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases .

HY-14181

Cinaciguat 4 Publications Verification BAY 58-2667	Guanylate Cyclase	Cardiovascular Disease
Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

HY-12376

BAY 41-2272 3 Publications Verification	Guanylate Cyclase	Cardiovascular Disease Inflammation/Immunology
BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases *sGC* activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research .

HY-100565

SGC2085 1 Publications Verification	Histone Methyltransferase	Cancer
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-123940

SGC-AAK1-1 1 Publications Verification	Wnt AAK1	Cancer
SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC₅₀ of 270 nM and a K_i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 .

HY-W015084

β-Ionone 1 Publications Verification	Environmental Pollutants Apoptosis	Cancer
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-112804

SGC-iMLLT 2 Publications Verification	Epigenetic Reader Domain	Cancer
SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC₅₀ of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with K_ds of 0.129 and 0.077 μM, respectively .

HY-17500

Ataciguat 1 Publications Verification HMR-1766	Guanylate Cyclase	Cardiovascular Disease
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects .

HY-113926

BAY 60-2770	Guanylate Cyclase	Cardiovascular Disease
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect .

HY-109039

Praliciguat 2 Publications Verification IW-1973	Guanylate Cyclase Apoptosis	Cardiovascular Disease Metabolic Disease
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase (sGC) activator. Praliciguat can increases cGMP via the nitric oxide (NO)-sGC pathway. Praliciguat can inhibit the expression of proinflammatory cytokines and inhibit apoptosis. Praliciguat can promote vasodilation. Praliciguat can be used for the researches of metabolic disease and cardiovascular disease, such as hypertension, diabetes and heart failure .

HY-109136

Runcaciguat 1 Publications Verification BAY 1101042	Guanylate Cyclase	Cardiovascular Disease Metabolic Disease
Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic kidney disease (CKD) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF) .

HY-111457A

BAY-678 1 Publications Verification	Elastase	Inflammation/Immunology
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-114211

SGC8158	Histone Methyltransferase HSP	Cancer
SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC₅₀: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity .

HY-W013386

LY83583 1 Publications Verification	Guanylate Cyclase	Cardiovascular Disease Neurological Disease Cancer
LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease .

HY-W062836

BAY 41-8543	Guanylate Cyclase	Cardiovascular Disease
BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research .

HY-155805

SGC-CAF382-1	CDK	Cancer
CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain .

HY-109066

Olinciguat 1 Publications Verification IW-1701	Guanylate Cyclase	Cardiovascular Disease
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .

HY-19714

XY1 1 Publications Verification	Drug Derivative	Cancer
XY1 is an analog of SGC707 (HY-19715), a potent and selective PRMT3 inhibitor with an IC₅₀ of 31 nM. XY1 is completely inactive against PRMT3. XY1 and SGC707 represent an excellent pair of tools for further elucidating the biological functions and disease relevance of PRMT3 .

HY-W015084A

(E)-β-Ionone β-Lonone	Environmental Pollutants Apoptosis	Cancer
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-126300

SGC6870 1 Publications Verification	Histone Methyltransferase	Cancer
SGC6870, a chemical probe, is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC₅₀ of 77 nM .

HY-168905

SGC-CAMKK2-1	Calmodulin	Cancer
SGC-CAMKK2-1, a chemical probe, is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC₅₀ of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC₅₀ of 1.6 μM .

HY-153708

SGC-CLK-1 CAF-170	CDK	Cancer
SGC-CLK-1, a chemical probe, is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. SGC-CLK-1 can inhibit the growth of melanoma and glioblastoma cells .

HY-147083

SGC-AAK1-1N	AAK1	Cancer
SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC₅₀ of 1.8 μM .

HY-156350

SGC-STK17B-1	DAPK	Cancer
SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC₅₀: 34 nM, K_D: 5.6 nM) .

HY-172118

SGC-CDKL5/GSK3	GSK-3	Neurological Disease
CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC₅₀ values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases .

HY-155360

MY-1076 1 Publications Verification	YAP Apoptosis	Cancer
MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC₅₀ s of 0.019, 0.017, 0.020 and 0.044 μM, respectively .

HY-176268

SGC-NSP2hel-1 RA-0188293; RA-NSP2-1	DNA/RNA Synthesis Virus Protease Flavivirus	Infection
SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC₅₀ > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.

HY-162653

SGC-CDKL2/AAK1/BMP2K-1		Others
SGC-CDKL2/AAK1/BMP2K-1 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC₅₀ value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. SGC-CDKL2/AAK1/BMP2K-1 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases .

HY-117604

THPP-1 1 Publications Verification	Phosphodiesterase (PDE)	Neurological Disease
THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species .

HY-153092

Avenciguat BI-685509	Guanylate Cyclase	Cardiovascular Disease Metabolic Disease
Avenciguat (BI-685509) is a potent and orally active *sGC* activator. Avenciguat restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. Avenciguat can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD) .

HY-100565A

SGC2085 hydrochloride	Histone Methyltransferase	Cancer
SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-178335

SGC-CK1γ-1	LDLR Wnt CMV	Infection
SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection .

HY-117917

(Rac)-MGV354	Guanylate Cyclase	Cardiovascular Disease Inflammation/Immunology
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively .

HY-172193

UBD1031 SGC-UBD1031	Deubiquitinase HDAC	Inflammation/Immunology Cancer
UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC₅₀ of 10.6 μM, K_D value of 48 nM, and a human HDAC6-UBD K_D of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome .

HY-133083

BAY-474 1 Publications Verification	c-Met/HGFR	Cancer
BAY-474 is a tyrosine-protein kinase c-Met inhibitor. BAY-474 acts as an epigenetics probe .

HY-178191

SGC stimulator 1	Guanylate Cyclase Autophagy AMPK TGF-β Receptor	Cardiovascular Disease
sGC stimulator 1 is a carbonyl sulfide (COS)/H₂S-donor hybrid soluble guanylyl cyclase (sGC) stimulator (EC₅₀ = 496 nM). sGC stimulator 1 exhibits a well-characterized H₂S-releasing property. sGC stimulator 1 reduces fibrosis in TGF-β1-treated cardiac fibroblasts by increasing cGMP and H₂S levels. sGC stimulator 1 can exert anti-fibrotic effects by activating *sGC* and increasing H₂S. sGC stimulator 1 can be used for the study of heart failure (HF) .

HY-P11380

Capa-2	Neurotensin Receptor Calcium Channel NO Synthase Guanylate Cyclase	Neurological Disease Metabolic Disease
Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis .

HY-155697

SGC-UBD253	HDAC	Cancer
SGC-UBD253, a chemical probe, is a potent HDAC6-UBD antagonist. SGC-UBD253 can be used in research of cancer .

HY-168050

SGC-NSP2PRO-1	CHIKV Virus Protease	Infection
SGC-NSP2PRO-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC₅₀ value of 60 nM. SGC-NSP2PRO-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC₅₀ = 0.01 and 0.3 µM, respectively .

HY-119081

GSK2181236A	Guanylate Cyclase	Cardiovascular Disease
GSK2181236A is a NO-insensitive soluble guanylate cyclase (sGC) activator. GSK2181236A can dilate blood vessels, decrease mean arterial pressure and attenuate the development of cardiac hypertrophy. GSK2181236A can be used for the research of cardiovascular disease, such as hypertension .

Cat. No.	Product Name	Type

HY-14536

Methylene Blue

25+ Cited Publications

Basic Blue 9; CI-52015; Methylthioninium chloride

Fluorescent Dye

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-14536A

Methylene blue (purity≥70%)

Basic Blue 9 (purity≥70%); CI-52015 (purity≥70%); Methylthioninium chloride (purity≥70%)

Fluorescent Dye

Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-14536R

Methylene Blue (Standard)

Basic Blue 9 (Standard); CI-52015 (Standard); Methylthioninium chloride (Standard)

Fluorescent Dye

Methylene Blue (Standard) is the analytical standard of Methylene Blue. This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-160065F

*FAM-sgc8c aptamer sodium*	Fluorescent Dye
FAM-sgc8c aptamer sodium is a 5-FAM labeled sgc8c aptamer sodium (HY-160065). sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of FAM-sgc8c aptamer sodium to PTK-7 induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals .

HY-D3394

SGC5

Fluorescent Dye

SGC5 is a fluorescence enhancer and membrane dissociator with millisecond-scale membrane dissociation kinetics, with an emission spectrum of 500-650 nm. SGC5 produces strong fluorescence upon binding to lipid membranes, exhibits fast partitioning dissociation kinetics at higher temperatures, and is unaffected by pH or cholesterol. SGC5 does not belong to the FM dye family and shows the highest membrane-bound fluorescence intensity among the tested styryl/FM dyes. SGC5 can be used to study synaptic vesicle cycling in neurons .

HY-D3382

SGC3	Fluorescent Dye

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015084

β-Ionone 1 Publications Verification	Structural Classification Classification of Application Fields Viola odorata Linn. Ketones, Aldehydes, Acids Violaceae Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-W015084A

(E)-β-Ionone β-Lonone	Structural Classification Viola odorata Linn. Terpenoids Sesquiterpenes Violaceae Plants Source Classification	Environmental Pollutants Apoptosis
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Rubiaceae Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N10201

Cytoglobosin C	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Cancer Source Classification	Endogenous Metabolite
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide	Lignans Aglaia odorata Lour. Phenylpropanoids Plants Meliaceae Source Classification	Others
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-W015084R

β-Ionone (Standard)	Structural Classification Viola odorata Linn. Ketones, Aldehydes, Acids Violaceae Plants Source Classification	Reference Standards Apoptosis
β-Ionone (Standard) is the analytical standard of β-Ionone. This product is intended for research and analytical applications. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-N13136

Timosaponin D	Triterpenes Liliaceae Terpenoids Anemarrhena asphodeloides Bunge Plants Source Classification	Others
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-W015084AR

(E)-β-Ionone (Standard) β-Lonone (Standard)	Structural Classification Microorganisms Viola odorata Linn. Terpenoids Sesquiterpenes Violaceae Plants Source Classification	Apoptosis Reference Standards
(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-N17852

3-O-Arabinopyranosyl siaresinolic acid	Structural Classification Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Pentacyclic Triterpenoids Source Classification	Others
3-O-Arabinopyranosyl siaresinolic acid is a triterpenoid found in the roots of Sanguisorba officinalis. 3-O-Arabinopyranosyl siaresinolic acid shows no activity against cancer cells .

HY-N17005

3-O-(p-Hydroxybenzoyl)serratriol	Lycopodiaceae Structural Classification Palhinhaea cernua (L.) Vasc. & Franco Terpenoids Phenols Plants Pentacyclic Triterpenoids Source Classification	Others
3-O-(p-Hydroxybenzoyl)serratriol is a serratene-type triterpenoid compound with low cytotoxicity against cancer cells (IC₅₀ >100 μg/mL against three human cancer cell lines: K562, SMMC-7721, and SGC7901). 3-O-(p-Hydroxybenzoyl)serratriol can be naturally extracted from the whole plant of Palhinhaea cernua .

HY-N17349

(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol	Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Endogenous Metabolite
(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol (compound 3) is a cytotoxin that can be found in the marine bryozoan Bugula neritina. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol shows weak cytotoxicity against SGC7901 cell with an IC₅₀ value of 111.8 μM. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol can be used for the research of hepatocellular carcinoma, gastric carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-14779S3

Riociguat-d3
Riociguat-d₃ (BAY 632521-d₃) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-14779S

Riociguat-13C,d6
Riociguat- ¹³C,d₆ is the ¹³C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-W015084S

β-Ionone-13C3
β-Ionone- ¹³C₃ is the ¹³C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (1)
Application:	IHC-P (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82402

	Guanylyl Cyclase beta 1 Antibody (YA2147) GCbeta1; GCS beta 1; GCS beta 3; GUC1B3; GUCSB3; GUCY1B1; Gucy1b1; GUCY1B3; SGC	WB, IHC-P	Human, Mouse, Rat
	Guanylyl Cyclase beta 1 Antibody (YA2147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Guanylyl Cyclase beta 1.

HY-P810443

	REEP2 Antibody (YA9753) C5orf19, SGC32445, Receptor expression-enhancing protein 2, REEP2	WB, FC	Human, Rat
	REEP2 Antibody (YA9753) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to REEP2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-177571

Sgc8c-M SGC8c-VcMMAE		Aptamers
Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .

HY-160065

sgc8c aptamer sodium		Aptamers
sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7, thus achieving specific recognition and labeling of target cells .

HY-RS12791

SGCB Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SGCB Human Pre-designed siRNA Set A contains three designed siRNAs for SGCB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177870

Sgc8c Aptamer		Aptamers
Sgc8c Aptamer is a single-stranded DNA aptamer targeting protein tyrosine kinase 7 (PTK7) with K_d of 1.03-11.73 nM for human, mice, rat and monkey. Sgc8c Aptamer can be used to synthesize aptamer-drug conjugates and can be used for cancer research .

HY-RS17592

Srgn Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Srgn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srgn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

SGC

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products