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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
STAT6 PROTAC degrader
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "STAT6 PROTAC degrader" in MCE Product Catalog:
Cat. No.: HY-169179
CAS No.: 2984505-88-4
AK-1690 is a selective PROTAC degrader targeting STAT6 (DC50=1 nM) with a Ki of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc. .
Cat. No.: HY-176857
CAS No.: 3077464-21-9
Research Areas:
PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC) .
Cat. No.: HY-176919
CAS No.: 3077385-98-6
Research Areas:
PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC50 of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer .
Cat. No.: HY-169360
CAS No.: 2497585-50-7
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma .
Cat. No.: HY-172946
CAS No.: 3054116-24-1
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces STAT3 degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer .
Cat. No.: HY-176864
Research Areas:
STAT6 ligand-1 is a ligand for STAT6. STAT6 ligand-1 can be used for synthesizing PROTACs such as STAT6 degrader-2 (HY-176857) .
Cat. No.: HY-182699
CAS No.: 3077471-62-3
Research Areas:
PROTAC STAT6 degrader-5 is a PROTAC degrader that selectively targets STAT6. PROTAC STAT6 degrader-5 induces the degradation of STAT6 protein. PROTAC STAT6 degrader-5 can be used in inflammation and cancer research .
Cat. No.: HY-183834
CAS No.: 3077474-20-2
PROTAC STAT6 degrader-7 is a STAT6 PROTAC degrader with an IC50 of <0.1 μM. PROTAC STAT6 degrader-7 promotes ubiquitination and degradation of STAT6. PROTAC STAT6 degrader-7 can be used in cancer research .
Cat. No.: HY-181901
CAS No.: 3103198-34-8
Research Areas:
PROTAC STAT6 degrader-4 (Compound 3u247) is a STAT6 PROTAC degrader with a DC50 of 0.04 nM. PROTAC STAT6 degrader-4 promotes the ubiquitination and degradation of STAT6, and is applicable to the research of immune diseases .
Cat. No.: HY-183839
CAS No.: 3077464-57-1
Research Areas:
PROTAC STAT6 degrader-9 is a STAT6 PROTAC degrader with a DC50 value >1 μM and a DCmax value > 0.1 μM. PROTAC STAT6 degrader-9 has the potential for application in inflammation-related diseases .
Cat. No.: HY-183847
CAS No.: 3077464-23-1
Research Areas:
PROTAC STAT6 degrader-10 is a STAT6 PROTAC degrader with a DC50 value >1 μM and a DCmax value >0.1 μM. PROTAC STAT6 degrader-10 has the potential for application in inflammation-related diseases .
Cat. No.: HY-183837
CAS No.: 3077464-49-1
Research Areas:
PROTAC STAT6 degrader-8 is a STAT6 PROTAC degrader with a DC50 value >0.1 μM and a DCmax value > 0.01 μM. PROTAC STAT6 degrader-8 has the potential for application in inflammation-related diseases .
Cat. No.: HY-179608
CAS No.: 3067883-29-5
Research Areas:
E3 Ligase Ligand-linker Conjugate 218 is an E3 ligase ligand-linker conjugate, and can be used for synthesis of PROTAC STAT6 degrader-2 (HY-179233) .
Cat. No.: HY-184991
CAS No.: 2982853-56-3
Research Areas:
AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a Ki of 0.4 μM for STAT6 and a Ki of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
