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Pathways Recommended:	PROTAC

Results for "

STAT6 PROTAC degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (1) STAT (9) E3 Ligase Ligand-Linker Conjugates (1) PROTACs (8)
By Research Areas:	Cancer (9) Inflammation/Immunology (4)

Targets Recommended: STAT PROTAC-Linker Conjugates for PAC PROTAC Linkers Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-169179

AK-1690	PROTACs STAT	Cancer
AK-1690 is a selective *PROTAC* degrader targeting *STAT6* (DC₅₀=1 nM) with a K_i of 6 nM against human *STAT6. AK-1690 degrades* STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc. .

HY-176857

PROTAC STAT6 degrader-1	PROTACs STAT	Inflammation/Immunology Cancer
PROTAC STAT6 degrader-1 (Compound I-2) is a potent **STAT6 PROTAC** degrader with a DC₅₀ <1 nM. PROTAC STAT6 degrader-1 inhibits *STAT6* activity with an IC₅₀ of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC) .

HY-176919

PROTAC STAT6 degrader-3	PROTACs STAT	Inflammation/Immunology Cancer
PROTAC STAT6 degrader-3 is a potent **STAT6 PROTAC** degrader with a DC₅₀ of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer .

HY-169360

SD-436	PROTACs STAT	Cancer
SD-436 is a highly selective and efficacious **STAT3 PROTAC** degrader (DC₅₀: 0.5 μM), with IC₅₀ of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052) .

HY-179233

PROTAC STAT6 degrader-2	PROTACs STAT	Cancer
PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases .

HY-172946

SD-2301	PROTACs STAT	Cancer
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces *STAT3* degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer. (Pink: STAT3 ligand (HY-172947), Blue: VHL Ligand (HY-172948), Black: Linker (HY-W577012), VHL ligand-linker conjugate (HY-172949)) .

HY-176864

STAT6 ligand-1	Ligands for Target Protein for PROTAC STAT	Inflammation/Immunology Cancer
STAT6 ligand-1 is a ligand for *STAT6. STAT6* ligand-1 can be used for synthesizing PROTACs such as STAT6 degrader-2 (HY-176857) .

HY-183834

PROTAC STAT6 degrader-7	PROTACs STAT	Cancer
PROTAC STAT6 degrader-7 (Compound I-981) is a *STAT6* *PROTAC* degrader with an IC₅₀ of <0.1 μM. PROTAC STAT6 degrader-7 promotes ubiquitination and degradation of STAT6. PROTAC STAT6 degrader-7 can be used in cancer research .

HY-181901

PROTAC STAT6 degrader-4	PROTACs STAT	Inflammation/Immunology
PROTAC STAT6 degrader-4 (Compound 3u247) is a *STAT6* PROTAC degrader with a DC₅₀ of 0.04 nM. PROTAC STAT6 degrader-4 promotes the ubiquitination and degradation of STAT6, and is applicable to the research of immune diseases .

HY-182699

PROTAC STAT6 degrader-5

HY-179608

E3 Ligase Ligand-linker Conjugate 218	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 218 is an E3 ligase ligand-linker conjugate, and can be used for synthesis of PROTAC STAT6 degrader-2 (HY-179233) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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STAT6 PROTAC degrader

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